2,784 research outputs found
Pulse transducer with artifact signal attenuator
An artifact signal attenuator for a pulse rate sensor is described. The circuit for attenuating background noise signals is connected with a pulse rate transducer which has a light source and a detector for light reflected from blood vessels of a living body. The heart signal provided consists of a modulated dc signal voltage indicative of pulse rate. The artifact signal resulting from light reflected from the skin of the body comprises both a constant dc signal voltage and a modulated dc signal voltage. The amplitude of the artifact signal is greater and the frequency less than that of the heart signal. The signal attenuator circuit includes an operational amplifier for canceling the artifact signal from the output signal of the transducer and has the capability of meeting packaging requirements for wrist-watch-size packages
The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer
Peer reviewedPublisher PD
Chandra observation of the fast X-ray transient IGR J17544-2619: evidence for a neutron star?
IGR J17544-2619 belongs to a distinct group of at least seven fast X-ray
transients that cannot readily be associated with nearby flare stars or
pre-main sequence stars and most probably are X-ray binaries with wind
accretion. Sofar, the nature of the accretor has been determined in only one
case (SAX J1819.3-2525/V4641 Sgr). We carried out a 20 ks Chandra ACIS-S
observation of IGR J17544-2619 which shows the source in quiescence going into
outburst. The Chandra position confirms the previous tentative identification
of the optical counterpart, a blue O9Ib supergiant at 3 to 4 kpc (Pellizza,
Chaty & Negueruela, in prep.). This is the first detection of a fast X-ray
transient in quiescence. The quiescent spectrum is very soft. The photon index
of 5.9+/-1.2 (90% confidence error margin) is much softer than 6 quiescent
black hole candidates that were observed with Chandra ACIS-S (Kong et al. 2002;
Tomsick et al. 2003). Assuming that a significant fraction of the quiescent
photons comes from the accretor and not the donor star, we infer that the
accretor probably is a neutron star. A fit to the quiescent spectrum of the
neutron star atmosphere model developed by Pavlov et al. (1992) and Zavlin et
al. (1996) implies an unabsorbed quiescent 0.5--10 keV luminosity of
(5.2+/-1.3) x 10^32 erg/s. We speculate on the nature of the brief outbursts.Comment: accepted for publication in Astronomy & Astrophysic
A New Family of Multistep Methods with Improved Phase Lag Characteristics for the Integration of Orbital Problems
In this work we introduce a new family of ten-step linear multistep methods
for the integration of orbital problems. The new methods are constructed by
adopting a new methodology which improves the phase lag characteristics by
vanishing both the phase lag function and its first derivatives at a specific
frequency. The efficiency of the new family of methods is proved via error
analysis and numerical applications.Comment: 21 pages, 3 figures, 1 tabl
Men, Muscles, and Body Image: Comparisons of Competitive Bodybuilders, Weight Trainers, and Athletically Active Controls
Objectives: To investigate body image and psychosocial adjustment among competitive bodybuilders, non-competitive weight trainers, and athletically active men. Methods: Participants were 40 men in each of the three groups who were assessed on body composition and multiple facets of body image evaluation, investment and anxiety, eating attitudes, and social self esteem. Results: Relative to the other two groups, competitive bodybuilders had greater body mass due to fat-free body mass. Although groups did not differ in their situational body image discomfort, competitive bodybuilders and weight trainers had a more positive global appearance evaluation and were more psychologically invested in their physical appearance. Compared with active controls, men in both weightlifting groups were more satisfied with their upper torso and muscle tone. Competitive bodybuilders reported more mid torso satisfaction than the other two groups. Competitive bodybuilders also wished to be significantly heavier than controls did and reported higher social self esteem but greater eating disturbance. Conclusions: The findings suggest that competitive bodybuilders as a group are not more muscle dysmorphic\u27\u27 than either non-competitive weight trainers or physically active men who do not train with weights
Brain Age from the Electroencephalogram of Sleep
The human electroencephalogram (EEG) of sleep undergoes profound changes with
age. These changes can be conceptualized as "brain age", which can be compared
to an age norm to reflect the deviation from normal aging process. Here, we
develop an interpretable machine learning model to predict brain age based on
two large sleep EEG datasets: the Massachusetts General Hospital sleep lab
dataset (MGH, N = 2,621) covering age 18 to 80; and the Sleep Hearth Health
Study (SHHS, N = 3,520) covering age 40 to 80. The model obtains a mean
absolute deviation of 8.1 years between brain age and chronological age in the
healthy participants in the MGH dataset. As validation, we analyze a subset of
SHHS containing longitudinal EEGs 5 years apart, which shows a 5.5 years
difference in brain age. Participants with neurological and psychiatric
diseases, as well as diabetes and hypertension medications show an older brain
age compared to chronological age. The findings raise the prospect of using
sleep EEG as a biomarker for healthy brain aging
Spatial Correlation Function of X-ray Selected AGN
We present a detailed description of the first direct measurement of the
spatial correlation function of X-ray selected AGN. This result is based on an
X-ray flux-limited sample of 219 AGN discovered in the contiguous 80.7 deg^2
region of the ROSAT North Ecliptic Pole (NEP) Survey. Clustering is detected at
the 4 sigma level at comoving scales in the interval r = 5-60 h^-1 Mpc. Fitting
the data with a power law of slope gamma=1.8, we find a correlation length of
r_0 = 7.4 (+1.8, -1.9) h^-1 Mpc (Omega_M=0.3, Omega_Lambda=0.7). The median
redshift of the AGN contributing to the signal is z_xi=0.22. This clustering
amplitude implies that X-ray selected AGN are spatially distributed in a manner
similar to that of optically selected AGN. Furthermore, the ROSAT NEP
determination establishes the local behavior of AGN clustering, a regime which
is poorly sampled in general. Combined with high-redshift measures from optical
studies, the ROSAT NEP results argue that the AGN correlation strength
essentially does not evolve with redshift, at least out to z~2.2. In the local
Universe, X-ray selected AGN appear to be unbiased relative to galaxies and the
inferred X-ray bias parameter is near unity, b_X~1. Hence X-ray selected AGN
closely trace the underlying mass distribution. The ROSAT NEP AGN catalog,
presented here, features complete optical identifications and spectroscopic
redshifts. The median redshift, X-ray flux, and X-ray luminosity are z=0.41,
f_X=1.1*10^-13 cgs, and L_X=9.2*10^43 h_70^-2 cgs (0.5-2.0 keV), respectively.
Unobscured, type 1 AGN are the dominant constituents (90%) of this soft X-ray
selected sample of AGN.Comment: 17 pages, 8 figures, accepted for publication in ApJ, a version with
high-resolution figures is available at
http://www.eso.org/~cmullis/papers/Mullis_et_al_2004b.ps.gz, a
machine-readable version of the ROSAT NEP AGN catalog is available at
http://www.eso.org/~cmullis/research/nep-catalog.htm
A Suborbital Payload for Soft X-ray Spectroscopy of Extended Sources
We present a suborbital rocket payload capable of performing soft X-ray
spectroscopy on extended sources. The payload can reach resolutions of
~100(lambda/dlambda) over sources as large as 3.25 degrees in diameter in the
17-107 angstrom bandpass. This permits analysis of the overall energy balance
of nearby supernova remnants and the detailed nature of the diffuse soft X-ray
background. The main components of the instrument are: wire grid collimators,
off-plane grating arrays and gaseous electron multiplier detectors. This
payload is adaptable to longer duration orbital rockets given its comparatively
simple pointing and telemetry requirements and an abundance of potential
science targets.Comment: Accepted to Experimental Astronomy, 12 pages plus 1 table and 17
figure
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Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription
Birt–Hogg–Dubé (BHD) syndrome is an inherited cancer susceptibility disease characterized by skin and kidney tumors, as well as cystic lung disease, which results from loss-of-function mutations in the BHD gene. BHD is also inactivated in a significant fraction of patients with sporadic renal cancers and idiopathic cystic lung disease, and little is known about its mode of action. To investigate the molecular and cellular basis of BHD tumor suppressor activity, we generated mutant Bhd mice and embryonic stem cell lines. BHD-deficient cells exhibited defects in cell-intrinsic apoptosis that correlated with reduced expression of the BH3-only protein Bim, which was similarly observed in all human and murine BHD-related tumors examined. We further demonstrate that Bim deficiency in Bhd−/− cells is not a consequence of elevated mTOR or ERK activity, but results instead from reduced Bim transcription associated with a general loss of TGFβ-mediated transcription and chromatin modifications. In aggregate, this work identifies a specific tumor suppressive mechanism for BHD in regulating TGFβ-dependent transcription and apoptosis, which has implications for the development of targeted therapies
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