Interview with Kokosing Gap Trail Chairman, Phil Samuel

Phil Samuels speaks of the Gap Trail, and how it was founded through the Federal Gasoline Sales Tax along with how the entirety of the trail used to be railroad tracks. He also talks about the importance of the Gap Trail to the community, and how it increases the value of the areas around it, along with the overall community on the trail. It is an important commodity and amenity for the community.https://digital.kenyon.edu/ffp_interviews/1013/thumbnail.jp

Burnout and Quality of Life among Active Member Physicians of the Medical Society of Sedgwick County

Introduction. The medical literature suggests disturbingly high ratesof burnout among US physicians. The objective of this study was todetermine the rates of burnout, other forms of distress, and overallquality of life among physicians in Sedgwick County.Methods.xThe study involved a convenience sample of 197 physicianswho were active member physicians of the Medical Society of SedgwickCounty (MSSC). Between July and August 2018, we surveyed872 physicians who were active members of the MSSC. The surveyassessed manifestations of burnout, symptoms of depression and suicidalideation, fatigue, and quality of life. The authors used standarddescriptive summary statistics, Mann-Whitney U test/independentsamples t-Test, Fisher’s exact test, and correlations to analyze thedata.Results. The participation rate was 44.6%, with 49.5% of therespondents reporting manifestations of burnout. Although 85% ofthe participants rated their overall quality of life as good/very good,45% screened positive for depression, 5% had thoughts of suicideduring the past year, and 44% reported excessive fatigue during thepast week. Those with manifestations of burnout were 2.13 (100%vs 46.9%, p < 0.01) times more likely to report thoughts of suicidalideation, 2.43 (72.6% vs 30.4%; p < 0.001) times more likely to screenpositive for depression, and 1.89 (67.5% vs 35.8%; p < 0.001) timesmore likely to have high degrees of fatigue. All of the participants whohad suicidal ideation reported manifestations of burnout.Conclusions. Burnout was prevalent among active member physiciansof the MSSC. Burnout among the participants was associatedwith symptoms of depression, fatigue, suicidal ideation, and intentionof leaving the medical profession via early retirement and/or careerchange. Kans J Med 2019;12(2):33-39

Compendium-Wide Analysis of Pseudomonas aeruginosa Core and Accessory Genes Reveals Transcriptional Patterns across Strains PAO1 and PA14.

Pseudomonas aeruginosa is an opportunistic pathogen that causes difficult-to-treat infections. Two well-studied divergent P. aeruginosa strain types, PAO1 and PA14, have significant genomic heterogeneity, including diverse accessory genes present in only some strains. Genome content comparisons find core genes that are conserved across both PAO1 and PA14 strains and accessory genes that are present in only a subset of PAO1 and PA14 strains. Here, we use recently assembled transcriptome compendia of publicly available P. aeruginosa RNA sequencing (RNA-seq) samples to create two smaller compendia consisting of only strain PAO1 or strain PA14 samples with each aligned to their cognate reference genome. We confirmed strain annotations and identified other samples for inclusion by assessing each sample\u27s median expression of PAO1-only or PA14-only accessory genes. We then compared the patterns of core gene expression in each strain. To do so, we developed a method by which we analyzed genes in terms of which genes showed similar expression patterns across strain types. We found that some core genes had consistent correlated expression patterns across both compendia, while others were less stable in an interstrain comparison. For each accessory gene, we also determined core genes with correlated expression patterns. We found that stable core genes had fewer coexpressed neighbors that were accessory genes. Overall, this approach for analyzing expression patterns across strain types can be extended to other groups of genes, like phage genes, or applied for analyzing patterns beyond groups of strains, such as samples with different traits, to reveal a deeper understanding of regulation

Purdue College of Pharmacy Experience with Blood Pressure Screenings at the Indiana State Fair

The objective of this community outreach initiative is to develop and implement a student-led blood pressure screening at the Indiana State Fair in conjunction with the Purdue College of Pharmacy and the Hook’s Drug Store Museum. Under the mentorship of two pharmacy faculty members, third- and fourth-year professional PharmD students and pharmacy fellows hold a nine-hour blood pressure screening at the Indiana State Fair each year. The screening is held at the Hook’s Drug Store Museum and the students and fellows sign-up in teams of 3-4 to host the event. Fair-goers visiting the screening have their blood pressure taken using automated blood pressure devices and the readings are recorded into one of three categories: ≤140 mmHg/≤90 mmHg, \u3e140 mmHg/\u3e90 mmHg, or \u3e150 mmHg/\u3e100 mmHg. All patients receive a card with their blood pressure reading, are counseled on hypertension management and possible health complications, and receive a sticker that reads “I had my blood pressure checked at the Indiana State Fair/Purdue College of Pharmacy.” Students complete a reflection following their involvement. Data from the last five years was analyzed. Over the five years, a total of 838 fairgoers have utilized the opportunity to have their blood pressure checked. In addition, 50 pharmacy students, two fellows, and two faculty members have participated in hosting the screening. There has been growing involvement over the years, with 213 individuals visiting the booth in 2019. There has been a steady increase in the percentage of patients with a blood pressure reading in the lowest category. Participation in the Indiana State Fair has become a tradition for the College of Pharmacy as students enjoy and are grateful for such learning opportunities. This initiative allows students to develop and apply their clinical knowledge and communication skills while improving health and awareness of community members

Children\u27s Perceptions of Parent-Child Relationships: A Narrative, Inductive Approach

Background: Narrative methods can allow researchers to gather rich data from children regarding their perceptions of their relationship with parents that may not otherwise be captured using tasks, questionnaires, or structured interviews; however, existing coding systems have been established with samples that are largely White and middle class. The current study sought to establish child-inspired codes that would better reflect the sample. Methods: Children aged 5-12 years (M=8.82, 48.9% female) and their caregivers were recruited from high-poverty urban US areas. All participants identified as Black or African American. Children were audiotaped while speaking, uninterrupted, for three minutes about their relationship with their primary caregiver (TMSS; Marshall et al., 1990). A team of five researchers - diverse in race, ethnicity, and background - established a codebook using in-vivo methods, dually coded N=51 transcripts via thematic analysis, and analyzed codes for emergent themes (Braun & Clarke, 2006). Results: Coders identified N=671 codes from the transcripts, of which 332 (49.5%) were unique codeable units. Five themes emerged from the data: interactions, feelings about caregiver, emotional closeness, reciprocity, and insight. Conclusions: The use of open-ended speech sampling coupled with qualitative coding allowed cataloging of Black children’s own perceptions of the parent-child relationship. Children emphasized time spent together, mutual understanding, & reciprocity. Many children also showed insight into parents’ perspectives and motivations, including financial awareness. Previous work indicates this dyadic reciprocity may be one way families protect themselves against the negative consequences of financial difficulties (Wilhoit et al., 2021). References: Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3, 77–101. https://doi.org/10.1191/1478088706qp063oa Marshall, V.G., Longwell, L., Goldstein, M.J., & Swanson, J.M. (1990). Family factors associated with aggressive symptomatology in boys with Attention Deficit Hyperactivity Disorder: A research note. J. Child Psychol. Psychiat., 31(4), 629-636. https://doi.org/10.1111/j.1469-7610.1990.tb00802.x Wilhoit, S.A., Trentacosta, C.J., Beeghly, M., Boeve, J.L., Lewis, T.L. and Thomason, M.E. (2021). Household chaos and early childhood behavior problems: The moderating role of mother–child reciprocity in lower-income families. Fam Relat, 70, 1040-1054. https://doi.org/10.1111/fare.12560https://scholarscompass.vcu.edu/gradposters/1174/thumbnail.jp

Effect of interfractional shoulder motion on low neck nodal targets for patients treated using volume modulated arc therapy (VMAT)

Purpose: To quantify the dosimetric impact of interfractional shoulder motion on targets in the low neck for head and neck patients treated with volume modulated arc therapy (VMAT).Methods: Three patients with head and neck cancer were selected. All three required treatment to nodal regions in the low neck in addition to the primary tumor site. The patients were immobilized during simulation and treatment with a custom thermoplastic mask covering the head and shoulders. One VMAT plan was created for each patient utilizing two full 360° arcs and a second plan was created consisting of two superior VMAT arcs matched to an inferior static AP supraclavicular field. A CT-on-rails alignment verification was performed weekly during each patient’s treatment course. The weekly CT images were registered to the simulation CT and the target contours were deformed and applied to the weekly CT. The two VMAT plans were copied to the weekly CT datasets and recalculated to obtain the dose to the deformed low neck contours.Results: The average observed shoulder position shift in any single dimension relative to simulation was 2.5 mm. The maximum shoulder shift observed in a single dimension was 25.7 mm. Low neck target mean doses, normalized to simulation and averaged across all weekly recalculations were 0.996, 0.991, and 1.033 (Full VMAT plan) and 0.986, 0.995, and 0.990 (Half-Beam VMAT plan) for the three patients, respectively. The maximum observed deviation in target mean dose for any individual weekly recalculation was 6.5%, occurring with the Full VMAT plan for Patient 3.Conclusion: Interfractional variation in dose to low neck nodal regions was quantified for three head and neck patients treated with VMAT. Mean dose was 3.3% higher than planned for one patient using a Full VMAT plan. A Half-Beam technique is likely a safer choice when treating the supraclavicular region with VMAT.-------------------------------------------Cite this article as: Casey K, Wang P, Tung S, Rosenthal D. Effect of interfractional shoulder motion on low neck nodal targets for patients treated using volume modulated arc therapy (VMAT). Int J Cancer Ther Oncol 2014; 2(2):020218. DOI: 10.14319/ijcto.0202.1

Doesn\u27t Your Work Just Re-Center Whiteness? The Fallen Impossibilities of White Allyship

Our purpose is to engage performative dialogue incorporative of currere on a central question in critical White studies (CWS). After precautionary notes and positionalities, we frame our dialogue within second-wave CWS. As its main section, six CWS scholars respond to the central question: Doesn’t research on White identities re-center whiteness? Analyzing the scholars’ responses, the performative dialogue is followed by an analytical discussion of CWS’ epistemological, ontological, and axiological convolutions. Via these convolutions, we recognize the impossibilities of facile “White allyship” within antiracist scholarship, curriculum and pedagogy, and related social movements. Instead of White allyship, we propose situated, relational, and process-oriented notions of alliance-oriented antiracist work

Altered Regulation of Aquaporin Gene Expression in Allergen and IL-13-Induced Mouse Models of Asthma

IL-13 is known to affect many processes that contribute to an asthmatic phenotype, including inflammation, fibrosis, and mucus production. Members of the aquaporin (AQP) family of transmembrane water channels are targets of regulation in models of lung injury and inflammation. Therefore, we examined AQP mRNA and protein expression in allergen and IL-13-induced mouse models of asthma. Lungs from ovalbumin sensitized and ovalbumin challenged (OVA/OVA) and IL-13 treated mice showed airway thickening, increased mucus production, and pulmonary eosinophilia. Pulmonary function tests showed a significant increase in methacholine-induced airway hyperreactivity in OVA/OVA and IL-13-treated mice as compared with controls. Quantitative PCR analysis revealed differential regulation of AQPs in these two models. AQP1 and AQP4 mRNA expression was downregulated in the OVA/OVA model, but not in the IL-13 model. AQP5 mRNA was reduced in both models, whereas AQP3 was upregulated only in the IL-13 model. Western analysis showed that diminished expression of an apically localized aquaporin, (AQP5), and concomitant upregulation of a basolateral aquaporin (AQP3 or AQP4) are characteristic features of both inducible asthma models. These results demonstrate that aquaporins are common targets of gene expression in both allergen and IL-13 induced mouse models of asthma