Hoe een Braziliaanse bijl in de patriottentijd belandde

Horizon 2020(H2020)ERC Agreement No. 715423Museum Studie

Corantes de batata doce roxa para uso em alimentos.

Um processo de preparo de produtos corantes a partir da batata doce roxa, Ipomoea batatas, Lam., Convulvolaceae, de polpa roxa, foi desenvolvida visando seu emprego como aditivo corante em alimentos. Os produtos corantes resultaram da solubilização do amido, constituinte principal da batata doce, que se atingiu por meio de hidrólise acida com ácidos minerais, como os ácidos clorídrico ou sulfúrico, ou por meio de hidrólises enzimáticas. Hidrólises ácidas seguidas de hidrólises enzimáticas com amiloglicosidase e hidrólises enzimáticas com amilase seguida de amiloglicosidase foram consideradas mais efetivas. Produtos concentrados líquidos viscosos de 72 Brix e produtos em pó obtidos por liofilização e secagem por "spray" foram preparados, cujo teor em antocianinas foi de 0,24%, 0,15% e 0,12% respectivamente. Ensaios de intensidade de cor e conservação dos corantes em função do meio forma feitos. O processo de obtenção dos corantes de batata doce roxa, desenvolvido no CTAA, constitui-se em processo inovador tanto no que se refere a mateira prima empregada quanto ao processamento e um pedido de privilegio de inovação foi redigido para avaliação no INPI.bitstream/item/65377/1/CTAA-DOCUMENTOS-9-CORANTES-DE-BATATA-DOCE-ROXA-PARA-USO-EM-ALIMENTOS-FL-06785.pd

The first Dutch SDHB founder deletion in paraganglioma – pheochromocytoma patients

Contains fulltext : 81280.pdf (publisher's version ) (Open Access)BACKGROUND: Germline mutations of the tumor suppressor genes SDHB, SDHC and SDHD play a major role in hereditary paraganglioma and pheochromocytoma. These three genes encode subunits of succinate dehydrogenase (SDH), the mitochondrial tricarboxylic acid cycle enzyme and complex II component of the electron transport chain. The majority of variants of the SDH genes are missense and nonsense mutations. To date few large deletions of the SDH genes have been described. METHODS: We carried out gene deletion scanning using MLPA in 126 patients negative for point mutations in the SDH genes. We then proceeded to the molecular characterization of deletions, mapping breakpoints in each patient and used haplotype analysis to determine whether the deletions are due to a mutation hotspot or if a common haplotype indicated a single founder mutation. RESULTS: A novel deletion of exon 3 of the SDHB gene was identified in nine apparently unrelated Dutch patients. An identical 7905 bp deletion, c.201-4429_287-933del, was found in all patients, resulting in a frameshift and a predicted truncated protein, p.Cys68HisfsX21. Haplotype analysis demonstrated a common haplotype at the SDHB locus. Index patients presented with pheochromocytoma, extra-adrenal PGL and HN-PGL. A lack of family history was seen in seven of the nine cases. CONCLUSION: The identical exon 3 deletions and common haplotype in nine patients indicates that this mutation is the first Dutch SDHB founder mutation. The predominantly non-familial presentation of these patients strongly suggests reduced penetrance. In this small series HN-PGL occurs as frequently as pheochromocytoma and extra-adrenal PGL

Quem somos nós? Ou perfis da comunidade profissional arqueológica no Brasil: primeiras aproximações

WHO ARE WE? OR A PROFILE OF THE ARCHAEOLOGICAL PROFESSIONAL COMMUNITY IN BRAZIL: FIRST APPROACHESIn the last twenty years, archeological academic-scientific training has grown exponen-tially in Brazil, culminating in the recognition of the profession in 2018. However, little is known about the demographic profiles of people working in the area, as well as of students in the process of training, in undergraduate and graduate levels. By updating some data from previous studies, in this manuscript we present the results of an initial survey on the professional profile in Brazilian archeology, which includes information on the trajectory of education, gender, nationality and re-search themes. This initiative allows us to outline the challenges of inclusion and representativeness in the exercise of the profession, whose reflections will assist us in the conceiving of practical measures for a change in this situation in the future.Archaeology of the AmericasArchaeological Heritage Managemen

National and firm-level drivers of the devolution of HRM decision making to line managers

Multinational companies must understand the influences on responsibility for managing people so that they can manage talent consistently thus ensuring that it is transferable across locations. We examine the impact of firm and national level characteristics on the devolution of HRM decision making to line managers. Our analysis draws on data from 2335 indigenous organizations in 21 countries. At the firm level, we found that where the HR function has higher power, devolution is less likely. At the national level, devolution of decision making to line management is more likely in societies with more stringent employment laws and lower power distance

Murine Models and Cell Lines for the Investigation of Pheochromocytoma: Applications for Future Therapies?

Pheochromocytomas (PCCs) are slow-growing neuroendocrine tumors arising from adrenal chromaffin cells. Tumors arising from extra-adrenal chromaffin cells are called paragangliomas. Metastases can occur up to approximately 60% or even more in specific subgroups of patients. There are still no well-established and clinically accepted “metastatic” markers available to determine whether a primary tumor is or will become malignant. Surgical resection is the most common treatment for non-metastatic PCCs, but no standard treatment/regimen is available for metastatic PCC. To investigate what kind of therapies are suitable for the treatment of metastatic PCC, animal models or cell lines are very useful. Over the last two decades, various mouse and rat models have been created presenting with PCC, which include models presenting tumors that are to a certain degree biochemically and/or molecularly similar to human PCC, and develop metastases. To be able to investigate which chemotherapeutic options could be useful for the treatment of metastatic PCC, cell lines such as mouse pheochromocytoma (MPC) and mouse tumor tissue (MTT) cells have been recently introduced and they both showed metastatic behavior. It appears these MPC and MTT cells are biochemically and molecularly similar to some human PCCs, are easily visualized by different imaging techniques, and respond to different therapies. These studies also indicate that some mouse models and both mouse PCC cell lines are suitable for testing new therapies for metastatic PCC