Mothers\u27 and Fathers\u27 Responses on the Child Behavior Checklist: Are There Systematic Differences?

This study examined parental responses on the Child Behavior Checklist (CBCL), and considered variables that may affect rating reliability. Subjects for the study were 82 matched parent-pairs who completed CBCL protocols on their clinic-referred children. Research variables included parent gender, child gender, and level of item objectivity. The data was analyzed at the CBCL scale (narrowband) and broadband (Externalizing and Internalizing) levels, utilizing analysis of mean differences, repeated-measures analysis of variance, and clinical classification agreement. Results showed little or no mean difference between mothers\u27 and fathers\u27 scores, but a large degree of discrepancy for parent-pairs was evident. None of the associated ANOVA F-tests were statistically significant. On analyses that investigated parent-gender by child-gender interaction effects, no significant gender differences were found between mother vs. father discrepancies. Diagnostic classification analyses revealed a tendency for mothers to classify children in the clinical range more often than fathers, although differences were not statistically significant. Kappas and Occurrence Agreement Indices were low to moderate (k ranged from .30 to .55, and OAIs ranged from .28 to .53, respectively). Regarding item objectivity. Externalizing Scales (composed of items rated as more objective or observable), demonstrated greater parental agreement (higher kappas) and higher reliabilities than Internalizing Scales. These results revealed no systematic differences between mother and father ratings, and therefore continued use of common norms is supported. However, the low to moderate reliabilities and indices of agreement suggest that the CBCL be used with caution when making diagnostic or treatment decisions

Glucocorticosteroids for people with alcoholic hepatitis

This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the benefits and harms of glucocorticosteroids in people with alcoholic hepatitis

FibroTest, transient elastography method, and combined FibroTest and transient elastography method for diagnosis of severe hepatic fibrosis and cirrhosis in adults with chronic hepatitis C

This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the diagnostic accuracy of FibroTest, transient elastography method, combined FibroTest and transient elastography method, no matter the sequence, using liver biopsy as reference standard, for assessment of severe hepatic fibrosis and cirrhosis in adults with chronic hepatitis C without any co-infections such as hepatitis B, HIV, and alcoholic liver disease. To compare the accuracy of FibroTest, transient elastography method, combined FibroTest and transient elastography method, for assessment of hepatic fibrosis in adults with chronic hepatitis C. To explore heterogeneity analysing the following study factors: different grade of inflammation according to the liver biopsy; different lengths of liver biopsy sample; different number of portal tracts included in a liver biopsy sample; different serum levels of ALT activity. different grade of inflammation according to the liver biopsy; different lengths of liver biopsy sample; different number of portal tracts included in a liver biopsy sample; different serum levels of ALT activity

Coefficient Quantization for Frames in Banach Spaces

Let $(e_i)$ be a fundamental system of a Banach space. We consider the problem of approximating linear combinations of elements of this system by linear combinations using quantized coefficients. We will concentrate on systems which are possibly redundant. Our model for this situation will be frames in Banach spaces.Comment: 33 page

Ultrasonography for diagnosis of alcoholic cirrhosis in people with alcoholic liver disease

BACKGROUND: Heavy alcohol consumption causes alcoholic liver disease and is a causal factor of many types of liver injuries and concomitant diseases. It is a true systemic disease that may damage the digestive tract, the nervous system, the heart and vascular system, the bone and skeletal muscle system, and the endocrine and immune system, and can lead to cancer. Liver damage in turn, can present as multiple alcoholic liver diseases, including fatty liver, steatohepatitis, fibrosis, alcoholic cirrhosis, and hepatocellular carcinoma, with presence or absence of hepatitis B or C virus infection. There are three scarring types (fibrosis) that are most commonly found in alcoholic liver disease: centrilobular scarring, pericellular fibrosis, and periportal fibrosis. When liver fibrosis progresses, alcoholic cirrhosis occurs. Hepatocellular carcinoma occurs in 5% to 15% of people with alcoholic cirrhosis, but people in whom hepatocellular carcinoma has developed are often co-infected with hepatitis B or C virus.Abstinence from alcohol may help people with alcoholic disease in improving their prognosis of survival at any stage of their disease; however, the more advanced the stage, the higher the risk of complications, co-morbidities, and mortality, and lesser the effect of abstinence. Being abstinent one month after diagnosis of early cirrhosis will improve the chance of a seven-year life expectancy by 1.6 times. Liver transplantation is the only radical method that may change the prognosis of a person with alcoholic liver disease; however, besides the difficulties of finding a suitable liver transplant organ, there are many other factors that may influence a person's survival.Ultrasound is an inexpensive method that has been used for years in clinical practice to diagnose alcoholic cirrhosis. Ultrasound parameters for assessing cirrhosis in people with alcoholic liver disease encompass among others liver size, bluntness of the liver edge, coarseness of the liver parenchyma, nodularity of the liver surface, size of the lymph nodes around the hepatic artery, irregularity and narrowness of the inferior vena cava, portal vein velocity, and spleen size.Diagnosis of cirrhosis by ultrasound, especially in people who are asymptomatic, may have its advantages for the prognosis, motivation, and treatment of these people to decrease their alcohol consumption or become abstinent.Timely diagnosis of alcoholic cirrhosis in people with alcoholic liver disease is the cornerstone for evaluation of prognosis or choosing treatment strategies. OBJECTIVES: To determine the diagnostic accuracy of ultrasonography for detecting the presence or absence of cirrhosis in people with alcoholic liver disease compared with liver biopsy as reference standard.To determine the diagnostic accuracy of any of the ultrasonography tests, B-mode or echo-colour Doppler ultrasonography, used singly or combined, or plus ultrasonography signs, or a combination of these, for detecting hepatic cirrhosis in people with alcoholic liver disease compared with liver biopsy as a reference standard, irrespective of sequence. SEARCH METHODS: We performed searches in The Cochrane Hepato-Biliary Group Controlled Trials Register, The Cochrane Hepato-Biliary Group Diagnostic Test Accuracy Studies Register, The Cochrane Library (Wiley), MEDLINE (OvidSP), EMBASE (OvidSP), and the Science Citation Index Expanded to 8 January 2015. We applied no language limitations.We screened study references of the retrieved studies to identify other potentially relevant studies for inclusion in the review and read abstract and poster publications. SELECTION CRITERIA: Three review authors independently identified studies for possible inclusion in the review. We excluded references not fulfilling the inclusion criteria of the review protocol. We sent e-mails to study authors.The included studies had to evaluate ultrasound in the diagnosis of hepatic cirrhosis using only liver biopsy as the reference standard.The maximum time interval of investigation with liver biopsy and ultrasonography should not have exceeded six months. In addition, ultrasonography could have been performed before or after liver biopsy. DATA COLLECTION AND ANALYSIS: We followed the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. MAIN RESULTS: The review included two studies that provided numerical data regarding alcoholic cirrhosis in 205 men and women with alcoholic liver disease. Although there were no applicability concerns in terms of participant selection, index text, and reference standard, we judged the two studies at high risk of bias. Participants in both studies had undergone both liver biopsy and ultrasonography investigations. The studies shared only a few comparable clinical signs and symptoms (index tests).We decided to not perform a meta-analysis due to the high risk of bias and the high degree of heterogeneity of the included studies. AUTHORS' CONCLUSIONS: As the accuracy of ultrasonography in the two included studies was not informative enough, we could not recommend the use of ultrasonography as a diagnostic tool for liver cirrhosis in people with alcoholic liver disease. In order to be able to answer the review questions, we need diagnostic ultrasonography prospective studies of adequate sample size, enrolling only participants with alcoholic liver disease.The design and report of the studies should follow the Standards for Reporting of Diagnostic Accuracy. The sonographic features, with validated cut-offs, which may help identify clinical signs used for diagnosis of fibrosis in alcoholic liver disease, should be carefully selected to achieve maximum diagnostic accuracy on ultrasonography

A Guide to Localized Frames and Applications to Galerkin-like Representations of Operators

This chapter offers a detailed survey on intrinsically localized frames and the corresponding matrix representation of operators. We re-investigate the properties of localized frames and the associated Banach spaces in full detail. We investigate the representation of operators using localized frames in a Galerkin-type scheme. We show how the boundedness and the invertibility of matrices and operators are linked and give some sufficient and necessary conditions for the boundedness of operators between the associated Banach spaces.Comment: 32 page

The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse

BACKGROUND: The hematopoietic stem cells (HSCs) niche of the bone marrow is comprised of HSCs, osteoblasts, endothelial cells and a stromal component of non-hematopoietic multipotent cells of mesenchymal origin named "mesenchymal stem cells" (MSCs). RESULTS: Here we studied the global transcriptional profile of murine MSCs with immuno-therapeutic potential and compared it with that of 486 publicly available microarray datasets from 12 other mouse tissues or cell types. Principal component analysis and hierarchical clustering identified a unique pattern of gene expression capable of distinctively classifying MSCs from other tissues and cells. We then performed an analysis aimed to identify absolute and relative abundance of transcripts in all cell types. We found that the set of transcripts uniquely expressed by MSCs is enriched in transcription factors and components of the Wnt signaling pathway. The analysis of differentially expressed genes also identified a set of genes specifically involved in the HSC niche and is complemented by functional studies that confirm the findings. Interestingly, some of these genes play a role in the maintenance of HSCs in a quiescent state supporting their survival and preventing them from proliferating and differentiating. We also show that MSCs modulate T cell functions in vitro and, upon in vivo administration, ameliorate experimental autoimmune encephalomyelitis (EAE). CONCLUSION: Altogether, these findings provide novel and important insights on the mechanisms of T cell function regulation by MSCs and help to cement the rationale for their application in the treatment of autoimmune diseases

Reproductive traits of the invasive species Acacia dealbata Link. in the northern Mediterranean basin

Among the many exotic plants introduced in the last two centuries in Northern Mediterranean Basin Acacia dealbata Link. is one of the most invasive. Despite its presence in the region since many years, it has not yet been investigated how the species has established itself and has formed small forests. In this study, we aimed to gather data on reproductive trait of the invasive species A. dealbata at the northern limit of the Mediterranean bioclimatic region. In six naturalized populations, fruit and seed set were estimated and seed germination was tested in laboratory. Two out of the six populations failed to set fruits, and the fruit set was always low as observed in other invaded areas of the world. Only three populations produced germinating seeds whose rates were comparable to other invasive areas. The seeds may constitute a long-lasting seed bank that may favour the colonization of the species in areas disturbed by external factors. In conclusion, the reproductive system may contributes only partially to the spread and invasiveness of the species in the Northern Mediterranean basin, while the plant to spread itself adopts also other vegetative strategies