Quantum simulation of multiphoton and nonlinear dissipative spin-boson models

We present a framework for the realization of dissipative evolutions of spin-boson models, including multiphoton exchange dynamics, as well as nonlinear transition rates. Our approach is based on the implementation of a generalized version of a dissipative linear quantum Rabi model. The latter comprises a linearly coupled spin-boson term, spin rotations, and standard dissipators. We provide numerical simulations of illustrative cases supporting the good performance of our method. Our work allows for the simulation of a large class of fundamentally different quantum models where the effect of distinct dissipative processes can be easily investigated.Comment: 14 pages, 6 figs. Comments are welcome

Measuring Entanglement in a Photonic Embedding Quantum Simulator

Measuring entanglement is a demanding task that usually requires full tomography of a quantum system, involving a number of observables that grows exponentially with the number of parties. Recently, it was suggested that adding a single ancillary qubit would allow for the efficient measurement of concurrence, and indeed any entanglement monotone associated to antilinear operations. Here, we report on the experimental implementation of such a device---an embedding quantum simulator---in photonics, encoding the entangling dynamics of a bipartite system into a tripartite one. We show that bipartite concurrence can be efficiently extracted from the measurement of merely two observables, instead of fifteen, without full tomographic information.Comment: Updated versio

Speeding up quantum perceptron via shortcuts to adiabaticity

The quantum perceptron is a fundamental building block for quantum machine learning. This is a multidisciplinary field that incorporates abilities of quantum computing, such as state superposition and entanglement, to classical machine learning schemes. Motivated by the techniques of shortcuts to adiabaticity, we propose a speed-up quantum perceptron where a control field on the perceptron is inversely engineered leading to a rapid nonlinear response with a sigmoid activation function. This results in faster overall perceptron performance compared to quasi-adiabatic protocols, as well as in enhanced robustness against imperfections in the controls.We acknowledge financial support from Spanish Government via PGC2018-095113-B-I00 (MCIU/AEI/FEDER, UE), Basque Government via IT986-16, as well as from QMiCS (820505) and OpenSuperQ (820363) of the EU Flagship on Quantum Technologies, and the EU FET Open Grant Quromorphic (828826). J. C. acknowledges the Ramón y Cajal program (RYC2018- 025197-I) and the EUR2020-112117 Project of the Spanish MICINN, as well as support from the UPV/EHU through the Grant EHUrOPE. X. C. acknowledges NSFC (12075145), SMSTC (2019SHZDZX01-ZX04, 18010500400 and 18ZR1415500), the Program for Eastern Scholar and the Ramón y Cajal program of the Spanish MICINN (RYC-2017-22482). E. T. acknowledges support from Project PGC2018-094792-B-I00 (MCIU/AEI/FEDER,UE), CSIC Research Platform PTI-001, and CAM/FEDER Project No. S2018/TCS-4342 (QUITEMAD-CM

Encoding relativistic potential dynamics into free evolution

We propose a method to simulate a Dirac or Majorana equation evolving under particular potentials with the use of the corresponding free evolution, while the potential dynamics is encoded in a static transformation upon the initial state. We extend our results to interacting two-body systems.The authors acknowledge funding from Basque Government grants BFI08.211, IT559-10, and IT472-10; Spanish MICINN FIS2008-05705, FIS2009- 10061, and FIS2009-12773-C02-01; QUITEMAD; EC Marie-Curie program; UPV/EHU UFI 11/55; CCQED, SOLID and PROMISCE European projects.Peer Reviewe

Probabilistic eigensolver with a trapped-ion quantum processor

Preparing the eigenstate, especially the ground state, of a complex Hamiltonian is of great importance in quantum simulations. Many proposals have been introduced and experimentally realized, among which are quantum variational eigensolver and heat-bath algorithmic cooling, with the former hindered by local minima and the latter lacking of complex system Hamiltonians. Here we introduce a dissipative quantum-classical hybrid scheme, the probabilistic eigensolver. The scheme repeatedly uses an ancilla qubit to acquire information on the system, based on which it postselectively lowers the average energy of the system. The optimal reduction is achieved through classical optimization with a single variational parameter. We describe the implementation of the probabilistic eigensolver with trapped-ion systems and demonstrate the performance by numerically simulating the ground-state preparation of several paradigmatic models, including the Rabi and the Hubbard models. We believe the scheme would enrich the functionalities of universal quantum simulators and be useful as a module for various quantum-computation tasks

New insights on the role of connexins and Gap Junctions Channels in adipose tissue and Obesity

Due to the inability to curb the excessive increase in the prevalence of obesity and overweight, it is necessary to comprehend in more detail the factors involved in the pathophysiology and to appreciate more clearly the biochemical and molecular mechanisms of obesity. Thus, understanding the biological regulation of adipose tissue is of fundamental relevance. Connexin, a protein that forms intercellular membrane channels of gap junctions and unopposed hemichannels, plays a key role in adipogenesis and in the maintenance of adipose tissue homeostasis. The expression and function of Connexin 43 (Cx43) during the different stages of the adipogenesis are differentially regulated. Moreover, it has been shown that cell–cell communication decreases dramatically upon differentiation into adipocytes. Furthermore, inhibition of Cx43 degradation or constitutive overexpression of Cx43 blocks adipocyte differentiation. In the first events of adipogenesis, the connexin is highly phosphorylated, which is likely associated with enhanced Gap Junction (GJ) communication. In an intermediate state of adipocyte differentiation, Cx43 phosphorylation decreases, as it is displaced from the membrane and degraded through the proteasome; thus, Cx43 total protein is reduced. Cx is involved in cardiac disease as well as in obesity-related cardiovascular diseases. Different studies suggest that obesity together with a high-fat diet are related to the production of remodeling factors associated with expression and distribution of Cx43 in the atrium

Plan estratégico 2020-2024 para el Hotel Presidente

A través del presente documento se busca crear estrategias y definir procedimientos. Se trata de un plan de acción a largo plazo diseñado para lograr los objetivos estratégicos, que se diferencia de otras tácticas inmediatas realizadas previamente con los recursos disponibles. Este plan estratégico de largo alcance busca ayudar al Hotel Presidente a establecer sus prioridades y atender mejor las necesidades de las partes interesadas. El plan pretende ser flexible y práctico, además de servir como guía para implementar programas, evaluar cómo funcionan estos programas y hacer ajustes cuando sea necesario

Oxaliplatin-Associated Takotsubo Cardiomyopathy in a Patient with Metastatic Gastric Cancer: A Case Report

We present the case of a 64-year-old female with stage IV gastric adenocarcinoma, pulmonary, and abdominal wall metastases, and no history of cardiovascular disease. In palliative care, she received systemic cytotoxic treatment with fluorouracil, leucovorin, oxaliplatin, and docetaxel protocol, which was well tolerated over five cycles. During cycle 6, she presented with cardiovascular symptoms with hemodynamic consequences while receiving oxaliplatin injection without docetaxel or 5-fluorouracil. She was transferred to the emergency department and then to the intensive care unit. She developed no complications during the hospital stay and was discharged after 10 days with preserved systolic function and no structural changes at the myocardial level. The electrocardiogram, echocardiogram, cardiac catheterization, and magnetic resonance imaging findings indicated an oxaliplatin-associated Takotsubo syndrome. The immunochemistry analysis showed PD-L1 expression level TPS: 40% and the foundation one genomic profiling revealed high mutation load, microsatellite instability, and HER2 not found. The patient is currently asymptomatic and on pembrolizumab monotherapy with good tolerance and partial treatment response