Investigación sobre la frecuencia de deficiencia en G6PD y talasemia en varias provincias españolas

Memoria para optar al grado de doctor presentada por Ángela Casado Moragón.Peer reviewe

Técnicas y tecnologías en hidrología médica e hidroterapia

El objetivo del presente informe es difundir entre los profesionales médicos la información que contribuya a orientarles en la materia, conocer las aplicaciones terapéuticas o rehabilitadoras que pueden ofrecer los distintos centros termales y explorar su interacción con los tratamientos médicos habituales a los que suelen estar sometidos los usuarios de estos programas de termalismo

Measurement of quality of life of HIV individuals: Perspectives & future directions

Modification of medical outcome study (MOS) instrument for quality of life assessment & its validation in HIV infected individuals in IndiaPeer Reviewe

Beneficios de las aguas minerales en diferentes patologías

Trabajo presentado en la conferencia Actualizaciones Clínicas y Terapéuticas en Geriatría, celebrada en Madrid (España) el 12 de junio de 2013

Semblanza académica, científica y docente del Dr. José Antonio Abrisqueta Zarrabe

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Oxidative stress, thyroid dysfunction & Down syndrome

7 p.Down syndrome (DS) is one of the most common chromosomal disorders, occurring in one out of 700-1000 live births, and the most common cause of mental retardation. Thyroid dysfunction is the most typical endocrine abnormality in patients with DS. It is well known that thyroid dysfunction is highly prevalent in children and adults with DS and that both hypothyroidism and hyperthyroidism are more common in patients with DS than in the general population. Increasing evidence has shown that DS individuals are under unusual increased oxidative stress, which may be involved in the higher prevalence and severity of a number of pathologies associated with the syndrome, as well as the accelerated ageing observed in these individuals. The gene for Cu/Zn superoxide dismutase (SOD1) is coded on chromosome 21 and it is overexpressed (~50%) resulting in an increase of reactive oxygen species (ROS) due to overproduction of hydrogen peroxide (H2O2). ROS leads to oxidative damage of DNA, proteins and lipids, therefore, oxidative stress may play an important role in the pathogenesis of DS.This study was supported in part by Fundación Inocente, Inocente, Madrid, Spain.Peer reviewe

Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21

4 pag.-4 tab.Background: It has been suggested that an increase in oxidative stress in individuals with Down syndrome (DS) may cause adverse effects in the cell membranes through the oxidation of polyunsatured fatty acids. Methods: We examined erythrocyte malondialdehyde (MDA) levels in 100 individuals of both sexes (34 males and 66 females) with DS, aged from newborn to 29 years. The cytogenetic analysis revealed 90 individuals with regular trisomy 21, four individuals with trisomy 21 by Robertsonian (Rb) translocation, and six individuals with mosaic trisomy 21. DS individuals were divided into six age groups. The control group consisted of 100 healthy individuals of both sexes (40 males and 60 females) who were age-matched with DS subjects. Results: No significant differences were found in erythrocyte MDA levels between the sexes in any of the age groups for the DS group and the control group. We confirmed significantly higher erythrocyte levels of MDA in individuals with DS compared to the control group. A significant difference was observed in erythrocyte MDA levels between DS individuals with trisomy and controls for all age groups, and in individuals with DS due to Rb translocation trisomy. However, in DS individuals with mosaicism, MDA levels depended on the percentage of diploid and trisomy cells. Conclusions: Our results confirm an increase in lipid peroxidation in patients with DS. © 2007 by Walter de Gruyter.This research project was supported by Foundation Inocente, Inocente, and was rewarded with the Ramón Trias Fargas award for research on Down syndromePeer Reviewe

Age-Correlated Changes of the Erythrocyte Catalase Activity in the Spanish Population

[Background]: Oxygen free radical and reactive oxygen species are involved in many diseases and ageing. Scavening enzymes represent one of the several natural defence mechanisms against free radical induced damage. Catalase (CAT) is an enzyme that is involved in antioxidant defence.[Objective:] In order to establish a comprehensive profile of the erythrocyte CAT activity during ageing, we investigated this activity in human erythrocytes from 2,827 apparently healthy Spanish subjects (1,388 males and 1,439 females).[Methods]: We divided the subjects into twelve age groups (newborns and 1–3, 4–9, 10–19, 20–29, 30–39, 40–49, 50–59, 60–69, 70–79, 80–89, and >90 years of age) to evaluate ageing changes. The CAT activity was measured in haemolysates by the method of Aebi (see text).[Results]: No significant variations with respect to sex were detected, except for the 70- to 93-year age groups. In these elderly subjects, the CAT activity in males remained constant with no significant variations between age groups, whereas the CAT activity showed a significant increase in females. This fact is considered to be one of the outcomes of the greater longevity in females. Significant age-related modifications in erythrocyte CAT activity appeared in the group of newborns (p < 0.001), in the group 1–3 years of age (p < 0.025), and in the elderly groups: 70–79 years (p < 0.025) and 80–89 years (p < 0.05) of age.[Conclusion]: Our results confirm that the CAT activity in the Spanish population shows an interindividual variability and suggest that this variability may be due, at least in part, to the age of the individuals.Peer reviewe

Frequency of thalassemia and G6PD deficiency in five provinces of Spain

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