1,216 research outputs found
Superpulsed low-level laser therapy protects skeletal muscle of mdx mice against damage, inflammation and morphological changes delaying dystrophy progression.
Aim: To evaluate the effects of preventive treatment with low-level laser therapy (LLLT) on progression of dystrophy in mdx mice. Methods: Ten animals were randomly divided into 2 experimental groups treated with superpulsed LLLT (904 nm, 15 mW, 700 Hz, 1 J) or placebo-LLLT at one point overlying the tibialis anterior muscle (bilaterally) 5 times per week for 14 weeks (from 6th to 20th week of age). Morphological changes, creatine kinase (CK) activity and mRNA gene expression were assessed in animals at 20th week of age. Results: Animals treated with LLLT showed very few morphological changes in skeletal muscle, with less atrophy and fibrosis than animals treated with placebo-LLLT. CK was significantly lower (p = 0.0203) in animals treated with LLLT (864.70 U.lâ1, SEM 226.10) than placebo (1708.00 U.lâ1, SEM 184.60). mRNA gene expression of inflammatory markers was significantly decreased by treatment with LLLT (p<0.05): TNF-α (placebo-control = 0.51 ”g/”l [SEM 0.12], - LLLT = 0.048 ”g/”l [SEM 0.01]), IL-1ÎČ (placebo-control = 2.292 ”g/”l [SEM 0.74], - LLLT = 0.12 ”g/”l [SEM 0.03]), IL-6 (placebo-control = 3.946 ”g/”l [SEM 0.98], - LLLT = 0.854 ”g/”l [SEM 0.33]), IL-10 (placebo-control = 1.116 ”g/”l [SEM 0.22], - LLLT = 0.352 ”g/”l [SEM 0.15]), and COX-2 (placebo-control = 4.984 ”g/”l [SEM 1.18], LLLT = 1.470 ”g/”l [SEM 0.73]). Conclusion: Irradiation of superpulsed LLLT on successive days five times per week for 14 weeks decreased morphological changes, skeletal muscle damage and inflammation in mdx mice. This indicates that LLLT has potential to decrease progression of Duchenne muscular dystrophy
Artisanal fisheries in a Brazilian hypereutrophic reservoir: Barra Bonita reservoir, middle TietĂȘ river
AnĂĄlise estatĂstica do trauma ortopĂ©dico infanto-juvenil do pronto socorro de ortopedia de uma metrĂłpole tropical
Adherence to best care practices in normal birth: construction and validation of an instrument
Development of an ex vivo model of endovenous laser ablation of the great saphenous vein in a pilot study
Impacts of vinasse and methods of sugarcane harvesting on the availability of K and carbon stock of an Argisol
Welcoming with risk classification in teaching hospitals: assessment of structure, process and result
Perinatal factors associated with developmental defects of enamel in primary teeth: a case-control study
A 12-Year Retrospective Study of Avulsion Cases in a Public Brazilian Dental Trauma Service.
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