Membrane transport systems and the biodegradation potential and pathogenicity of genus Rhodococcus

PMID:24772091 WOS:000347032600001The Rhodococcus genus contains species with remarkable ability to tolerate toxic compounds and to degrade a myriad of substrates. These substrates have to cross a distinctive cell envelope dominated by mycolic acids anchored in a scaffold of arabinogalactan covalently attached to the cell wall peptidoglycan, and a cellular membrane with phospholipids, whose composition in fatty acids can be rapidly altered in response to environmental conditions. The hydrophobic nature of the cell envelope facilitates the entrance of hydrophobic molecules but some substrates require active transport systems. Additionally, toxic compounds may also be extruded by energy spending efflux systems. In this review, physiological evidences of the use of transport systems by Rhodococcus strains and genomic studies that corroborate their existence are presented and discussed. The recently released complete genomes of several Rhodococcus strains will be the basis for an in silico correlation analysis between the efflux pumps present in the genome and their role on active transport of substrates. These transport systems will be placed on an integrative perspective of the impact of this important genus on biotechnology and health, ranging from bioremediation to antibiotic and biocide resistance.publishersversionpublishe

Effect of Solution pH on the Removal of Paracetamol by Activated Carbon of Dende Coconut Mesocarp

Activated carbon of dende coconut mesocarp was used to investigate the removal of paracetamol from water by adsorption. The results indicated that the retention of paracetamol was favored in activated carbon with neutral surface properties. The textural features and presence of a transport pores network contributed to ensuring the accessibility to the inner porosity, and the microporosity must be large enough to accommodate the paracetamol molecule. Chemisorption and mainly physisorption are important in the paracetamol removal. Pseudo-second order equation and Langmuir model were chosen to best present the experimental data. The adsorption process was non-spontaneous and endothermic with increase in system disorder

Anticardiolipin Antibody In Recurrent Spontaneous Aborting And Fertile Women.

OBJECTIVE: To determine the association between the presence of anticardiolipin antibody and a history of recurrent spontaneous abortion. STUDY DESIGN: Clinical controlled study. LOCATION: Department of Gynecology and Obstetrics-University of Campinas (UNICAMP). SUBJECTS: 52 individuals with recurrent spontaneous abortion were included in Group 1 and 104 individuals with at least one live born child in Group 2. Elapsed time from last delivery to blood sampling varied from six months to two years. METHOD: Between November 1993 and November 1994, patients' blood samples were screened for anticardiolipin antibody by ELISA, as described by Triplett, Barna and Unger (1993). ANALYSIS: Chi-square and Fisher's Exact tests were used for statistical analysis. Student's "t" test was used to compare the means. RESULTS: There was no statistical difference in the presence of the anticardiolipin antibody between Group 1 (zero and 2.9%) and Group 2 (7.7 and 5.8%). CONCLUSION: There was no association between the presence of anticardiolipin antibody and recurrent spontaneous abortion.11641760176

Extração de amido de pinhão.

bitstream/item/121312/1/CT-349-Catie-.pd

Sistemas de pastejo rotacionado intensivo.

bitstream/item/87881/1/SISTEMA-PASTEJO.pdf1 folder

Sensor de variabilidade da frequência cardíaca como preditor de descompensaçao da insuficiência cardíaca e terapia de ressincronizaçao cardíaca

A insuficiência cardíaca é a via final comum à maioria das doenças cardiovasculares, sendo um dos mais importantes desafios clínicos atuais na área da saúde. Em 2007 foi a causa mais frequente de internaçoes por doenças cardiovasculares no Sistema Unico de Saúde. Em pacientes com insuficiência cardíaca, a atividade neuro-hormonal previne o resultado cardiovascular. A variabilidade da frequência cardíaca é uma medida indireta do tônus autonômico e serve como forma de predizer a possibilidade de morte súbita cardíaca e nao súbita. A variabilidade da frequência cardíaca tem sido proposta nao só para prever a falência cardíaca grave, mas também para conduzir o tratamento e talvez antecipar o diagnóstico da insuficiência cardíaca agudamente descompensada. A melhora clínica do paciente com insuficiência cardíaca após terapia de ressincronizaçao cardíaca demanda algum tempo, independentemente da melhora rápida dos parâmetros ecocardiográficos, sugerindo ser o remodelamento cardíaco reverso um processo dinâmico e que deve ser aguardado após a terapia de ressincronizaçao cardíaca. Neste trabalho é feita revisao bibliográfica complementada com a análise do prontuário de uma paciente com insuficiência cardíaca submetida a terapia de ressincronizaçao cardíaca, demonstrando que há melhora ecocardiográfica rápida mas que a melhora clínica se dá após algum tempo do implante do ressincronizador cardíaco. Conclui-se que o remodelamento reverso necessita, em alguns casos, de maior espaço de tempo após o implante do ressincronizador cardíaco para que haja resultados clínicos, os quais podem nao ocorrer ainda que haja melhora da fraçao de ejeçao ao ecocardiograma