Family Ownership and Firm Performance: A Closer Look at the Evidence from Public Companies in Chile

We revisit the evidence presented in Martinez et al. (2007) using new data and estimation techniques that take into account unobserved firm heterogeneity. The results of the earlier study are found to be robust to the new procedures since performance of family firms continues to be superior to non-family firms. We then add the risk dimension to the earlier analysis using a risk-adjusted ROA variable, and family firms again performed better. A test of the standard deviations of ROA for both firm categories revealed that family firms not only perform better but also show less volatility in their returns.Family firms, performance.

El cuidado centrado en la persona en fase avanzada de la enfermedad

doi: 10.5294/aqui.2017.17.3.

Augkit: an Augmented Drum Set System Designed for Live Performance

Augkit is an augmented drum set system designed for live performance. Augkit consists of a drum kit, microphone, audio interface, MIDI pad controller with foot switches, set of speakers, and a computer. I designed the processing audio engine in the visual programming language Max. Max processes the audio signal in a variety of ways that include delays, flanger, reverb, and synthesis that depend on the frequency content of the signal. Foot switches and MIDI pads toggle and modify the parameters of Augkit. This approach to playing drum set proves to be very flexible and offers new aesthetic possibilities for live performance and interaction with other musicians

Genetic and Molecular Factors in Drug-Induced Liver Injury: A Review

The diagnosis of drug-induced liver injury (DILI) is challenging and based on complex diagnostic criteria. DILI falls into two main categories i) intrinsic 'dose-dependent' Type A reactions ii) 'idiosyncratic' or Type B reactions (which are usually not predictable). Idiosyncratic reactions can be immunoallergic (hypersensitivity), or metabolic, although overlap between categories can occur. The aim of this review is to summarise the general view of underlying mechanisms in DILI and to highlight individual risk factors for developing hepatotoxicity. Polymorphisms of bioactivation/ toxification pathways through CYP450 enzymes (Phase I), detoxification reactions (Phase II) and excretion/transport (Phase III) are explored together with immunological factors that might determine DILI. The importance of establishing a multidisciplinary and multi-centric network to promote the understanding and research in hepatotoxicity is underlined. Challenges such as genetic analyses for association studies and whole genome studies, pharmacogenetic testing and future approaches to study DILI are considered. Knowledge regarding these operational mechanisms could provide further insight for the prospective identification of susceptible patients at risk of developing drug-induced hepatotoxicity.

Carpal tunnel syndrome associated with oral bisphosphonates. A population-based cohort study

© 2016 Carvajal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: Bisphosphonates are widely used to prevent osteoporotic fractures. Some severe musculoskeletal reactions have been described with this medication; among them, some cases of carpal tunnel syndrome. Thus, the aim of this study was to explore whether bisphosphonates may be associated with this syndrome. Methods: A cohort study was conducted to compare exposed to unexposed women; the exposed group was that composed of women having received at least one prescription of an oral bisphosphonate. For the purpose, we used information from The Health Improvement Network (THIN) database. The outcome of interest was defined as those women diagnosed with carpal tunnel syndrome. A survival analysis was performed; the Cox proportional hazard model was used to calculate hazard ratios and 95% confidence intervals, and to adjust for identified confounding variables. Results: Out of a sample of 59,475 women older than 51 years, 19,825 were treated with bisphosphonates during the period studied. No differences in age distribution or mean follow-up time were observed between the two groups in comparison. Overall, there were 572 women diagnosed with carpal tunnel syndrome, 242 (1.2%) in the group exposed to bisphosphonates, and 330 (0.8%) in the unexposed. An adjusted hazard ratio of developing carpal tunnel syndrome of 1.38 (95%CI, 1.15-1.64) was found for women exposed to bisphosphonates; no significant changes in the hazard ratios were found when considering different levels of bisphosphonate exposure

Axion Like Particles and the Inverse Seesaw Mechanism

Light pseudoscalars known as axion like particles (ALPs) may be behind physical phenomena like the Universe transparency to ultra-energetic photons, the soft $\gamma$-ray excess from the Coma cluster, and the 3.5 keV line. We explore the connection of these particles with the inverse seesaw (ISS) mechanism for neutrino mass generation. We propose a very restrictive setting where the scalar field hosting the ALP is also responsible for generating the ISS mass scales through its vacuum expectation value on gravity induced nonrenormalizable operators. A discrete gauge symmetry protects the theory from the appearance of overly strong gravitational effects and discrete anomaly cancellation imposes strong constraints on the order of the group. The anomalous U$(1)$ symmetry leading to the ALP is an extended lepton number and the protective discrete symmetry can be always chosen as a subgroup of a combination of the lepton number and the baryon number.Comment: 29pp. v4: published version with erratum. Conclusions unchange

Mo1169 Description of findings of endoscopic ultrasound in patients with idiopathic acute pancreatitis, at fourth level university hospital at Bogota between 2011-2013

Q1Q1https://orcid.org/0000-0003-2938-7731https://orcid.org/0000-0001-5660-6229https://orcid.org/0000-0002-9219-4548https://orcid.org/0000-0003-4279-3603Revista Internacional - Indexad

Revalidación de Ditomotarsus hyadesi Signoret, 1885 stat. rest. (Hemiptera: Heteroptera: Acanthosomatidae), con notas acerca de su historia natural

Ditomotarsus hyadesi Signoret, 1885 is revalidated. An historical analysis of the references belonging to this species is provided. Ditomotarsus gayi virens Jensen-Haarup, 1931 is proposed as new junior synonym of Ditomotarsus hyadesi. New data is provided on the biology of D. hyadesi. First observations on oviposition process are delivered and discussed. New data on sexual behavior is recorded and discussed. Ontogenic coloration changes for this species are for first time recorded, becoming the first in the Ditomotarsinae. The distribution and life history of the species are summarized.Ditomotarsus hyadesi Signoret, 1885 es revalidada y se provee un análisis histórico de las referencias bibliográficas correspondientes a esta especie. Se entrega nueva información acerca de la biología de D. hyadesi. Se entregan y discuten las primeras observaciones acerca de la oviposición en esta especie; además de nuevos datos acerca de su comportamiento sexual. Se registran también por primera vez para esta especie cambios de coloración ontogénicos, los que serían también los primeros registrados en la subfamilia Ditomotarsinae.  Finalmente se analiza y discute la distribución e historia natural de la especie