[Results of the EGRET Detector Program]

This NASA grant has funded studies of cosmic objects observed by both the EGRET detector aboard the Compton Gamma-ray Observatory and Whipple Gamma-ray imaging telescope. The former has sensitivity up to a few GeV and latter has sensitivity starting at about 200 GeV extending up to beyond 10 TeV. Thus these instruments probe some of the most energetic phenomena in the universe. This program has been in place for several years and led to important results referred to below. The Whipple Observatory Imaging Cherenkov Telescope consists of a 10-meter reflector with a nanosecond photomultiplier-tube camera at the focal plane. During the time period covered by this grant, it had either 109 pixels or 151 pixels on a 1/4 degree hexagonal pattern. As a TeV gamma ray enters the atmosphere, it produces an electron/positron pair initiating an extensive air shower. Cherenkov light from the electrons and positrons in the shower form an image of the shower at the phototube camera. The shape and intensity of this image is used to distinguish gamma-ray initiated showers from cosmic-ray (largely proton and alpha-particle) background showers and to derive an energy estimate for the primary gamma-ray. The Whipple Observatory gamma-ray collaboration pioneered this imaging technique which normally rejects over 99 percent of the cosmic-ray background while keeping over 70 percent of the gamma-ray signal. One of its key features is 2 large collection area which can exceed 50,000 meters. This grant covered primarily correlated observations of Markarian 421 and observations of the Cygnus region. The former resulted in a multiwavelength campaign showing correlations in several wavebands. The TeV data showed dramatic variability with the emission characterized by day-scale flickering and with now well defined steady component

Pathogenicity locus, core genome, and accessory gene contributions to Clostridium difficile virulence

Clostridium difficile is a spore-forming anaerobic bacterium that causes colitis in patients with disrupted colonic microbiota. While some individuals are asymptomatic C. difficile carriers, symptomatic disease ranges from mild diarrhea to potentially lethal toxic megacolon. The wide disease spectrum has been attributed to the infected host’s age, underlying diseases, immune status, and microbiome composition. However, strain-specific differences in C. difficile virulence have also been implicated in determining colitis severity. Because patients infected with C. difficile are unique in terms of medical history, microbiome composition, and immune competence, determining the relative contribution of C. difficile virulence to disease severity has been challenging, and conclusions regarding the virulence of specific strains have been inconsistent. To address this, we used a mouse model to test 33 clinical C. difficile strains isolated from patients with disease severities ranging from asymptomatic carriage to severe colitis, and we determined their relative in vivo virulence in genetically identical, antibiotic-pretreated mice. We found that murine infections with C. difficile clade 2 strains (including multilocus sequence type 1/ribotype 027) were associated with higher lethality and that C. difficile strains associated with greater human disease severity caused more severe disease in mice. While toxin production was not strongly correlated with in vivo colonic pathology, the ability of C. difficile strains to grow in the presence of secondary bile acids was associated with greater disease severity. Whole-genome sequencing and identification of core and accessory genes identified a subset of accessory genes that distinguish high-virulence from lower-virulence C. difficile strains

Extended emotion

Recent thinking within philosophy of mind about the ways cognition can extend has yet to be integrated with philosophical theories of emotion, which give cognition a central role. We carve out new ground at the intersection of these areas and, in doing so, defend what we call the extended emotion thesis: the claim that some emotions can extend beyond skin and skull to parts of the external worl

Very High Energy Gamma-Ray Emission from the Blazar Markarian 421

Very high energy gamma-ray emission from the BL Lac object Markarian 421 has been detected over three observing seasons on 59 nights between April 1992 and June 1994 with the Whipple 10-meter imaging Cherenkov telescope. During its initial detection in 1992, its flux above 500 GeV was 1.6$\times$10$^{-11}$photons cm$^{-2}$ s$^{-1}$. Observations in 1993 confirmed this level of emission. For observations made between December 1993 and April 1994, its intensity was a factor of 2.2$\pm$0.5 lower. Observations on 14 and 15 May, 1994 showed an increase over this quiescent level by a factor of $\sim$10 (Kerrick et al. 1995). This strong outburst suggests that 4 episodes of increased flux measurements on similar time scales in 1992 and 1994 may be attributed to somewhat weaker outbursts. The variability of the TeV gamma-ray emission from Markarian 421 stands in contrast to EGRET observations (Lin et al. 1994) which show no evidence for variability.Comment: gzip compressed tar file including LaTeX text and 4 postscript figures (14 pages total incl. 4 tables), accepted for publication in the Astrophysical Journal. Contact address is [email protected]

New Limits to the Infrared Background: Bounds on Radiative Neutrino Decay and on Contributions of Very Massive Objects to the Dark Matter Problem

From considering the effect of γ-γ interactions on recently observed TeV gamma-ray spectra, improved limits are set to the density of extragalactic infrared photons which are robust and essentially model independent. The resulting limits are more than an order of magnitude more restrictive than direct observations in the 0.025–0.3 eV regime. These limits are used to improve constraints on radiative neutrino decay in the mass range above 0.05 eV and to rule out very massive objects as providing the dark matter needed to explain galaxy rotation curves. Lower bounds on the maximum distance which TeV gamma rays may probe are also derived

The Hunt for Exomoons with Kepler (HEK): I. Description of a New Observational Project

Two decades ago, empirical evidence concerning the existence and frequency of planets around stars, other than our own, was absent. Since this time, the detection of extrasolar planets from Jupiter-sized to most recently Earth-sized worlds has blossomed and we are finally able to shed light on the plurality of Earth-like, habitable planets in the cosmos. Extrasolar moons may also be frequent habitable worlds but their detection or even systematic pursuit remains lacking in the current literature. Here, we present a description of the first systematic search for extrasolar moons as part of a new observational project called "The Hunt for Exomoons with Kepler" (HEK). The HEK project distills the entire list of known transiting planet candidates found by Kepler (2326 at the time of writing) down to the most promising candidates for hosting a moon. Selected targets are fitted using a multimodal nested sampling algorithm coupled with a planet-with-moon light curve modelling routine. By comparing the Bayesian evidence of a planet-only model to that of a planet-with-moon, the detection process is handled in a Bayesian framework. In the case of null detections, upper limits derived from posteriors marginalised over the entire prior volume will be provided to inform the frequency of large moons around viable planetary hosts, eta-moon. After discussing our methodologies for target selection, modelling, fitting and vetting, we provide two example analyses.Comment: 21 pages, 8 figures, 4 tables, accepted in Ap

Multiwavelength Observations of Markarian 421 in March 2001: an Unprecedented View on the X-ray/TeV Correlated Variability

(Abridged) We present a detailed analysis of week-long simultaneous observations of the blazar Mrk421 at 2-60 keV X-rays (RXTE) and TeV gamma-rays (Whipple and HEGRA) in 2001. The unprecedented quality of this dataset enables us to establish firmly the existence of the correlation between the TeV and X-ray luminosities, and to start unveiling some of its more detailed characteristics, in particular its energy dependence, and time variability. The source shows strong, highly correlated variations in X-ray and gamma-ray. No evidence of X-ray/gamma-ray interband lag is found on the full week dataset (<3 ks). However, a detailed analysis of the March 19 flare reveals that data are not consistent with the peak of the outburst in the 2-4 keV X-ray and TeV band being simultaneous. We estimate a 2.1+/-0.7 ks TeV lag. The amplitudes of the X-ray and gamma-ray variations are also highly correlated, and the TeV luminosity increases more than linearly w.r.t. the X-ray one. The strong correlation supports the standard model in which a unique electrons population produces the X-rays by synchrotron radiation and the gamma-ray component by inverse Compton scattering. However, for the individual best observed flares the gamma-ray flux scales approximately quadratically w.r.t. the X-ray flux, posing a serious challenge to emission models for TeV blazars. Rather special conditions and/or fine tuning of the temporal evolution of the physical parameters of the emission region are required in order to reproduce the quadratic correlation.Comment: Correction to authorship. Minor editorial changes to text, figures, references. 22 pages (emulateapj), 12 figures (47 postscript files) Published in ApJ, 2008 April 20 (ADS: 2008ApJ...677..906F

Far-Ultraviolet Dust Albedo Measurements in the Upper Scorpius Cloud Using the SPINR Sounding Rocket Experiment

The Spectrograph for Photometric Imaging with Numeric Reconstruction (SPINR) sounding rocket experiment was launched on 2000 August 4 to record far-ultraviolet (912-1450 A) spectral and spatial information for the giant reflection nebula in the Upper Scorpius region. The data were divided into three arbitrary bandpasses (912-1029 A, 1030-1200 A, and 1235-1450 A) for which stellar and nebular flux levels were derived. These flux measurements were used to constrain a radiative transfer model and to determine the dust albedo for the Upper Scorpius region. The resulting albedos were 0.28+/-0.07 for the 912-1029 A bandpass, 0.33+/-0.07 for the 1030-1200 A bandpass, and 0.77+/-0.13 for the 1235-1450 A bandpass