Condición oral de diabéticos tipo 2 hospitalizados durante los años 2015 y 2018. Estudio transversal.

Objective: To compare the oral condition between patients with type 2 diabetes mellitus and non-diabetics, hospitalized at the San Bernardo Parish Hospital (HPSB) during the years 2015 - 2018. Material and method: A cross-sectional study was conducted in which 439 hospitalized patients were assessed in the medicine and surgery services of the HPSB during 2015-2018. The prevalence of periodontal disease, caries, and tooth loss was determined. Also, risk factors for periodontitis were evaluated. The distribution of continuous variables was determined using the Shapiro Wilk test and the analysis was performed using the Mann-Whitney test, Chi-square, and logistic regression. Results: 82.05% of diabetic patients had periodontitis compared to 56.52% of non-diabetic patients (p-value <0.001). Diabetics had a caries prevalence of 66.67%, while the prevalence was 62.82% for non-diabetics (p-value = 0.200). The median number of tooth loss was 9 with an interquartile range (IQR) of 9 for non-diabetics and 14 (IQR 8) for diabetics (p-value <0.001). Diabetes behaved as a risk factor for periodontitis with an OR of 3.51 (95% CI 2.08 - 5.92; p-value <0.001). Conclusion: Hospitalized diabetic patients had a worse oral condition compared to non-diabetics, reflected in a higher prevalence of periodontal disease and the number of tooth loss. These results suggest the need to improve dental care in hospitalized diabetic patients. Objective: To compare the oral condition between patients with type 2 diabetes mellitus and non-diabetics, hospitalized at the San Bernardo Parish Hospital (HPSB) during the years 2015 - 2018.Material and method: A cross-sectional study was conducted in which 439 hospitalized patients were assessed in the medicine and surgery services of the HPSB during 2015-2018. The prevalence of periodontal disease, caries, and tooth loss was determined. Also, risk factors for periodontitis were evaluated. The distribution of continuous variables was determined using the Shapiro Wilk test and the analysis was performed using the Mann-Whitney test, Chi-square, and logistic regression.Results: 82.05% of diabetic patients had periodontitis compared to 56.52% of non-diabetic patients (p-value <0.001). Diabetics had a caries prevalence of 66.67%, while the prevalence was 62.82% for non-diabetics (p-value = 0.200). The median number of tooth loss was 9 with an interquartile range (IQR) of 9 for non-diabetics and 14 (IQR 8) for diabetics (p-value <0.001). Diabetes behaved as a risk factor for periodontitis with an OR of 3.51 (95% CI 2.08 - 5.92; p-value <0.001).Conclusion: Hospitalized diabetic patients had a worse oral condition compared to non-diabetics, reflected in a higher prevalence of periodontal disease and the number of tooth loss. These results suggest the need to improve dental care in hospitalized diabetic patients.Objetivo:Comparar la condición oral entre pacientes con diabetes mellitus tipo 2 y no diabéticos, hospitalizados en el Hospital Parroquial de San Bernardo (HPSB) durante los años 2015 - 2018. Materiales y Método:Se realizó un estudio transversal donde se evaluaron 439 pacienteshospitalizados en los servicios de medicina y cirugía del HPSB durante los años 2015-2018. Se determinó la prevalencia enfermedad periodontal, caries y pérdida dentaria. Además se evaluaron factores de riesgo de periodontitis. La distribución de las variables continuas se determinó mediante test de Shapiro Wilk y el análisis se realizó utilizando test deMann-Whitney, Chi-cuadrado y regresión logística.Resultados:Un 82,05% de los pacientes diabéticos presentó periodontitis comparado con un 56,52% de los no diabéticos (valor p < 0.001). Los diabéticos presentaron una prevalencia de 66,67% de caries mientras que la prevalencia fue de un 62,82% para los no diabéticos (valor p = 0,200).  La mediana del número de dientes ausentes, fue de 9 con un rango intercuartílico (RIC) de 9  para los no diabéticos y de 14 (RIC 8) para diabéticos (valor p < 0.001). La diabétes se comportó como un factor de riesgo de tener periodontis con un OR de 3,51 (IC 95% 2,08 – 5,92; valor p < 0,001).Conclusión:Los pacientes diabéticos hospitalizados presentaron peor condición oral que los no diabéticos, con mayor prevalencia de enfermedad periodontal y número de dientes perdidos. Se sugiere mejorar la atención odontológica en diabéticos

Willem Wilmink. Ik droomde dat ik wakker was

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Comparison of kyphoplasty with use of a calcium phosphate cement and non-operative therapy in patients with traumatic non-osteoporotic vertebral fractures

One of the current standard treatment options for younger patients with stable traumatic vertebral fractures is conservative treatment using braces. Kyphoplasty as a minimally invasive procedure has been shown to be effective in stabilizing vertebral body fractures, resulting in immediate pain relief and improved physical function. The purpose of this prospective study was to clarify whether patients with acute traumatic vertebral fractures benefit more from kyphoplasty or from conservative treatment with a brace. A prospective study was undertaken in two centers. Forty patients with acute painful traumatic vertebral body fractures type A1–A3 (AO-classification) after adequate trauma, without osteoporosis, suitable for kyphoplasty or therapy by brace were included into the study. Follow-up was 12 months. Patients of the kyphoplasty group showed an immediate beneficial and significant effect postoperatively, and better outcomes 1 and 3 months after operation compared to the conservatively treated group in pain feeling, mobility and vertebral body height. After 12 months the difference between both groups was not significant excepting the vertebral body height. Kyphoplasty provides early and lasting reduction of pain and improvement of daily activity. However, there are clinically asymptomatic cement leakages in up to 45% of which we do not know the consequences in long term. Every patient with traumatic vertebral body fracture treated by kyphoplasty has to be informed about that. Long-time results are outstanding and our findings require confirmation by randomized controlled trials

Evaluation of fatty acid extraction methods for Thraustochytrium sp. ONC-T18

Various extraction methods were assessed in their capacity to extract fatty acids from a dried biomass of Thraustochytrium sp. ONC-T18. Direct saponification using KOH in ethanol or in hexane:ethanol was one of the most efficient techniques to extract lipids (697 mg g-1). The highest amount of fatty acids (714 mg g-1) was extracted using a miniaturized Bligh and Dyer extraction technique. The use of ultrasonics to break down cell walls while extracting with solvents (methanol:chloroform) also offered high extraction yields of fatty acids (609 mg g-1). Moreover, when the transesterification mixture used for a direct transesterification method was doubled, the extraction of fatty acids increased approximately 77% (from 392 to 696 mg g-1). This work showed that Thraustochytrium sp. ONC-T18 has the ability to produce over 700 mg g-1 of lipids, including more than 165 mg g-1 of docosahexaenoic acid, which makes this microorganism a potential candidate for the commercial production of polyunsaturated fatty acids. Finally, other lipids, such as myristic, palmitic, palmitoleic, and oleic acids, were also produced and recovered in significant amounts (54, 196, 123, and 81 mg g-1), respectively. <br /