564 research outputs found
Representación hecha al Rey Ntro. Sor. por D. Francisco Carrasco... sobre amortización : real orden con que fué remitida al Consejo Pleno de Castilla : dictamen que en él ha dado en calidad de fiscal y última satisfacción à los reparos que se han opuesto
Copia digital : Biblioteca de Asturias "Ramón Pérez de Ayala" : Biblioteca Pública Estatal de Oviedo, 2010Fecha y lugar al final del texto: Madrid, 16 de noviembre de 1765Sign.: A5, B-E4, F
Data Deluge in Astrophysics: Photometric Redshifts as a Template Use Case
Astronomy has entered the big data era and Machine Learning based methods
have found widespread use in a large variety of astronomical applications. This
is demonstrated by the recent huge increase in the number of publications
making use of this new approach. The usage of machine learning methods, however
is still far from trivial and many problems still need to be solved. Using the
evaluation of photometric redshifts as a case study, we outline the main
problems and some ongoing efforts to solve them.Comment: 13 pages, 3 figures, Springer's Communications in Computer and
Information Science (CCIS), Vol. 82
Visual Performance Fields: Frames of Reference
Performance in most visual discrimination tasks is better along the horizontal than the vertical meridian (Horizontal-Vertical Anisotropy, HVA), and along the lower than the upper vertical meridian (Vertical Meridian Asymmetry, VMA), with intermediate performance at intercardinal locations. As these inhomogeneities are prevalent throughout visual tasks, it is important to understand the perceptual consequences of dissociating spatial reference frames. In all studies of performance fields so far, allocentric environmental references and egocentric observer reference frames were aligned. Here we quantified the effects of manipulating head-centric and retinotopic coordinates on the shape of visual performance fields. When observers viewed briefly presented radial arrays of Gabors and discriminated the tilt of a target relative to homogeneously oriented distractors, performance fields shifted with head tilt (Experiment 1), and fixation (Experiment 2). These results show that performance fields shift in-line with egocentric referents, corresponding to the retinal location of the stimulus
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar degeneration (FTLD-TDP). Identification of mutations in the gene encoding TDP-43 (TARDBP) in familial ALS confirms a mechanistic link between misaccumulation of TDP-43 and neurodegeneration and provides an opportunity to study TDP-43 proteinopathies in human neurons generated from patient fibroblasts by using induced pluripotent stem cells (iPSCs). Here, we report the generation of iPSCs that carry the TDP-43 M337V mutation and their differentiation into neurons and functional motor neurons. Mutant neurons had elevated levels of soluble and detergent-resistant TDP-43 protein, decreased survival in longitudinal studies, and increased vulnerability to antagonism of the PI3K pathway. We conclude that expression of physiological levels of TDP-43 in human neurons is sufficient to reveal a mutation-specific cell-autonomous phenotype and strongly supports this approach for the study of disease mechanisms and for drug screening
Porosity estimation of (Moso bamboo) by computed tomography and backscattered electron imaging
This study aims to investigate and quantify the porosity in the cross section of Phyllostachys edulis (Moso bamboo) culm wall. The porosity results are expected to be utilised in numerical study of heat and moisture transfer. Computed tomography (CT) and backscattered electron (BSE) imaging methods are utilised in this study because these two methods allow measurements of the anisotropic features of bamboo specimens. The results of these two methods can be represented as the function of the real dimension rather than the pore size distribution of the specimen. The specimens are obtained from eight different locations along the Moso bamboo culms. Both internodes and nodes specimens are measured in this study. The average porosity, standard deviation (SD) and coefficient of variation (COV) are calculated for BSE and CT results. Pearson product-moment correlation coefficient (PPMCC) is also calculated in this study to analyse the correlation between the BSE results and CT results. Typical porosity results from 400 sampling points and 10 portions average porosity are analysed in this study. The CT scanning results show similar trend with BSE results. The correlation relationship between BSE and CT results approaches moderate correlation level to strong correlation level. The average porosity of internode specimens is from 43.9 to 58.8 % by BSE measurement and from 44.9 to 63.4 % by CT measurement. The average porosity of node specimens is from 37.4 to 56.6 % by BSE measurement and from 32.1 to 62.2 % by CT measurement
Porosity estimation of Phyllostachys edulis (Moso bamboo) by computed tomography and backscattered electron imaging
This study aims to investigate and quantify the porosity in the cross
section of Phyllostachys edulis (Moso bamboo) culm wall. The porosity results are
expected to be utilised in numerical study of heat and moisture transfer. Computed
tomography (CT) and backscattered electron (BSE) imaging methods are utilised in
this study because these two methods allow measurements of the anisotropic features
of bamboo specimens. The results of these two methods can be represented as
the function of the real dimension rather than the pore size distribution of the
specimen. The specimens are obtained from eight different locations along the
Moso bamboo culms. Both internodes and nodes specimens are measured in this
study. The average porosity, standard deviation (SD) and coefficient of variation
(COV) are calculated for BSE and CT results. Pearson product-moment correlation
coefficient (PPMCC) is also calculated in this study to analyse the correlation
between the BSE results and CT results. Typical porosity results from 400 sampling
points and 10 portions average porosity are analysed in this study. The CT scanning
results show similar trend with BSE results. The correlation relationship between
BSE and CT results approaches moderate correlation level to strong correlation
level. The average porosity of internode specimens is from 43.9 to 58.8 % by BSE
measurement and from 44.9 to 63.4 % by CT measurement. The average porosity of
node specimens is from 37.4 to 56.6 % by BSE measurement and from 32.1 to
62.2 % by CT measurement
Health care utilization in the elderly Mexican population: Expenditures and determinants
<p>Abstract</p> <p>Background</p> <p>Worldwide population aging has been considered one of the most important demographic phenomena, and is frequently referred as a determinant of health costs and expenditures. These costs are an effect either of the aging process itself (social) or because of the increase that comes with older age (individual).</p> <p>Objective</p> <p>To analyze health expenditures and its determinants in a sample of Mexican population, for three dimensions acute morbidity, ambulatory care and hospitalization focusing on different age groups, particularly the elderly.</p> <p>Methods</p> <p>A secondary analysis of the Mexican National Health and Nutrition Survey (ENSANUT), 2006 was conducted. A descriptive analysis was performed to establish a health profile by socio-demographic characteristics. Logistic regression models were estimated to determine the relation between acute morbidity, ambulatory care, hospitalization and age group; to establish the determinants of hospitalization among the population 60 years and older; and to determine hospitalization expenditures by age.</p> <p>Results</p> <p>Higher proportion of elderly reporting health problems was found. Average expenditures of hospitalization in households were 308.9 am dlls, the highest among the considered age groups. The multivariate analysis showed higher probability of being hospitalized among the elderly, but not for risks for acute morbidity and ambulatory care. Among the elderly, older age, being male or living in a city or in a metro area implied a higher probability of hospitalization during the last year, with chronic diseases playing a key role in hospitalization.</p> <p>Conclusions</p> <p>The conditions associated with age, such as chronic diseases, have higher weight than age itself; therefore, they are responsible for the higher expenditures reported. Conclusions point towards a differentiated use and intensity of health services depending on age. The projected increase in hospitalization and health care needs for this group requires immediate attention.</p
- …