ENSAYOS DE PELADO EN "T" Y DE RESISTENCIA AL DESPEGUE EN REFUERZOS TEXTILES DE PINTURAS SOBRE LIENZO MEDIANTE SOPORTES RÍGIDOS: VALORACIÓN DE LAS UNIONES OBTENIDAS

ENSAYOS DE PELADO EN ¿T¿ Y DE RESISTENCIA AL DESPEGUE EN REFUERZOS TEXTILES DE PINTURAS SOBRE LIENZO MEDIANTE SOPORTES RÍGIDOS: VALORACIÓN DE LAS UNIONES OBTENIDAS.Carpio Sánchez, I. (2008). ENSAYOS DE PELADO EN "T" Y DE RESISTENCIA AL DESPEGUE EN REFUERZOS TEXTILES DE PINTURAS SOBRE LIENZO MEDIANTE SOPORTES RÍGIDOS: VALORACIÓN DE LAS UNIONES OBTENIDAS. http://hdl.handle.net/10251/14343Archivo delegad

El sólido capaz en la escultura polícroma como generador de una nueva legibilidad

Este trabajo expone la restauración realizada en colaboración con el Instituto de Restauración del Patrimonio de la Universidad Politécnica de Valencia, sobre una clave de bóveda del siglo XIII. Esta, presentaba un grave ataque de xilófagos y un estucado y redorado general, que ocultaban la talla gótica. Numerosos faltantes dificultaban la legibilidad de esta escultura. Una vez restaurada la pieza, y tratadas sus patologías, se han reconstruido las partes faltantes partiendo de la idea de sólido capaz, creando piezas volumétricas, mediante corte por sistema láser, que han devuelto la legibilidad a una obra que la había perdido. La colaboración con el IRP se ha centrado en valorar el brillo de estas piezas para asemejarlas al original.Juan Baldó, JM.; Carpio Sánchez, I.; Regidor Ros, JL. (2011). El sólido capaz en la escultura polícroma como generador de una nueva legibilidad. Arché. (6):193-200. http://hdl.handle.net/10251/33293193200

Development of Fish Oil-Loaded Microcapsules Containing Whey Protein Hydrolysate as Film-Forming Material for Fortification of Low-Fat Mayonnaise

The authors are very grateful to Lis Berner for her skillful help with the PV and SVOP measurements of the microcapsules.The influence of the carbohydrate-based wall matrix (glucose syrup, GS, and maltodextrin, MD21) and the storage temperature (4 ◦C or 25 ◦C) on the oxidative stability of microencapsulated fish oil was studied. The microcapsules (ca. 13 wt% oil load) were produced by spray-drying emulsions stabilized with whey protein hydrolysate (WPH), achieving high encapsulation efficiencies (>97%). Both encapsulating materials showed an increase in the oxidation rate with the storage temperature. The GS-based microcapsules presented the highest oxidative stability regardless of the storage temperature with a peroxide value (PV) of 3.49 ± 0.25 meq O2/kg oil and a content of 1-penten-3-ol of 48.06 ± 9.57 ng/g oil after six weeks of storage at 4 ◦C. Moreover, low-fat mayonnaise enriched with GS-based microcapsules loaded with fish oil and containing WPH as a film-forming material (M-GS) presented higher oxidative stability after one month of storage when compared to low-fat mayonnaise enriched with either a 5 wt% fish oil-in-water emulsion stabilized with WPH or neat fish oil. This was attributed to a higher protective effect of the carbohydrate wall once the microcapsules were incorporated into the mayonnaise matrix.Spanish Ministry of Science, Innovation and Universities CTQ2017-87076-R PRE2018-08486

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Study of the adhesive failure on tack-melt and hot-melt adhesives: questions about the perimeter supports treatments

Las propiedades reológicas y mecánicas de los materiales pictóricos tienen gran importancia en la intervención de pinturas de gran formato. De forma paralela, los materiales aplicados en la intervención de un soporte textil juegan un papel muy importante en la estabilización del mismo, y en la reología de éste. Este artículo estudia diferentes metodologías y materiales aplicados en tratamientos del soporte textil. Los estudios aquí descritos, muestran datos sobre ensayos experimentales y resultados semicuantitativos, para aquellos interesados en el estudio analítico y de la aplicabilidad de materiales sintéticos en este tipo de obras. En primer lugar se describen cuestiones referentes a adherencia entre los materiales de refuerzo, degradación de los soportes textiles y propiedades físico-químicas. En la segunda parte del artículo se muestran ejemplos concretos de la aplicación de los materiales ensayados, con el fin de proporcionar a las obras la estabilidad que éstas precisen en cada caso.Rheological and mechanical properties of painting materials are of prime importance on large size canvas restoration. In this way, the materials applied in the intervention of a textile support, plays a very important role in the stabilization of the same one, and in the rheology of this. This paper discusses the methods and materials used in a different number of substances, fabrics and adhesives. The methods and studies described here bring together the experimental processes and semi-quantitative results, in order to introduce them to those who are interested in the analytical study of the applicability of synthetic materials with this kind of work. First, questions like adherence between materials, degradation of the supports and physical-chemical properties, are described in detail. In the second part of the paper, concrete examples of the tested materials are shown, to provide the canvas with the stability required are discussed.Martín Rey, S.; Castell Agustí, M.; Iaccarino Ildelson, A.; Robles De La Cruz, C.; Carpio Sánchez, I.; Esteban Mínguez, CN. (2008). Estudio de los fallos adhesivos de las sustancias tack-melt y hot-melt: cuestiones relativas a los tratamientos perimetrales del soporte. Arché. (3):81-86. http://hdl.handle.net/10251/317588186

II. Conflictos entre felinos y humanos en América Latina.

Este libro contó con el liderazgo del Instituto Humboldt y de las Fundaciones Herencia Ambiental Caribe y Panthera. En 32 capítulos se recoge el esfuerzo de 77 instituciones y 110 autores que representan 18 países y abordan el conflicto entre humanos y felinos en América Latina. Es la compilación más completa que se ha elaborado acerca del tema en Latinoamérica, involucrando el análisis, la planificación, el manejo y la resolución de los conflictos entre humanos y felinos.BogotáCiencias de la Biodiversida

Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study an international prospective cohort study

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care

Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

International audienceIn this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected

Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Funding: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH