Learning Based on Problems (ABP), Impact of RAEE: A Case Study

Using a case of research as a methodological tool, applied in the research lab with students of the ninth semester of the academic program of chemical engineering (IQ) of the Faculty of chemical sciences and engineering (FCQeI) of the Autonomous University of the State of Morelos (UAEM), analyzed competition to students include scientific concepts acquired, where education is a human process more than verify that cognitive skills according to the approach [1], are developed during the resolution of the case. The results showed that students managed to explain the concepts involved, reflected on his own work and realized what had to be improved. For that, students employed higher order cognitive skills, such as explain, investigate, conclude, argue, make decisions and cognitive skills of low order, such as describing, enunciating, memorize and reproduce

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Comparison of photonic integrated circuits for millimeter-wave signal generation between dual-wavelength sources for optical heterodyning and pulsed mode-locked lasers

\u3cp\u3eA comparative study of two different Photonic Integrated Circuits (PICs) structures for continuous-wave generation of millimeter-wave (MMW) signals is presented, each using a different approach. One approach is optical heterodyning, using an integrated dual-wavelength laser source based on Arrayed Waveguide Grating. The other is based on ModeLocked Laser Diodes (MLLDs). A novel building block-Multimode Interference Reflectors (MIRs)-is used to integrate on-chip both structures, without need of cleaved facets to define the laser cavity. This fact enables us to locate any of these structures at any location within the photonic chip. As will be shown, the MLLD structure provides a simple source for low frequencies. Higher frequencies are easier to achieve by optical heterodyne. Both types of structures have been fabricated on a generic foundry in a commercial MPW PIC technology.\u3c/p\u3

Comparison of photonic integrated circuits for millimeter-wave signal generation between dual-wavelength sources for optical heterodyning and pulsed mode-locked lasers

A comparative study of two different Photonic Integrated Circuits (PICs) structures for continuous-wave generation of millimeter-wave (MMW) signals is presented, each using a different approach. One approach is optical heterodyning, using an integrated dual-wavelength laser source based on Arrayed Waveguide Grating. The other is based on ModeLocked Laser Diodes (MLLDs). A novel building block-Multimode Interference Reflectors (MIRs)-is used to integrate on-chip both structures, without need of cleaved facets to define the laser cavity. This fact enables us to locate any of these structures at any location within the photonic chip. As will be shown, the MLLD structure provides a simple source for low frequencies. Higher frequencies are easier to achieve by optical heterodyne. Both types of structures have been fabricated on a generic foundry in a commercial MPW PIC technology