Planktonic Food Web Structure at a Coastal Site

<p>Fluorescent Labeled Bacteria (FLB) Uptake Experiment- whole (unfiltered) seawater (WSW) was collected on the HOE Legacy 2A cruise near station ALOHA, Hawaii. Water was collected from the Niskin into 3, 2.3L bottles. FLBs were added to the bottles, and 100ml was removed and preserved from each bottle at T0. Bottles were incubated on-deck for 1h, at which point another 100ml was preserved from each bottle. Preserved samples were filtered onto 2.0um blackened polycarbonate filters and stained with DAPI. Slides were stored at -20C. </p&gt

Parallel extension of a dynamic performance forecasting tool

SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : RP 16133 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Parallel out-of-core matrix inversion

SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : RP 16121 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

The pathophysiology of osteoarthritis

Osteoarthritis (OA) is a complex disease whose pathogenesis includes the contribution of biomechanical and metabolic factors which, altering the tissue homeostasis of articular cartilage and subchondral bone, determine the predominance of destructive over productive processes. A key role in the pathophysiology of articular cartilage is played by cell/extra-cellular matrix (ECM) interactions, which are mediated by cell surface integrins. In a physiologic setting, integrins modulate cell/ECM signaling, essential for regulating growth and differentiation and maintaining cartilage homeostasis. During OA, abnormal integrin expression alters cell/ECM signaling and modifies chondrocyte synthesis, with the following imbalance of destructive cytokines over regulatory factors. IL-1, TNF-alpha and other pro-catabolic cytokines activate the enzymatic degradation of cartilage matrix and are not counterbalanced by adequate synthesis of inhibitors. The main enzymes involved in ECM breakdown are metalloproteinases (MMPs), which are sequentially activated by an amplifying cascade. MMP activity is partially inhibited by the tissue inhibitors of MMPs (TIMPs), whose synthesis is low compared with MMP production in OA cartilage. Intriguing is the role of growth factors such as TGF-beta, IFG, BMP, NGF, and others, which do not simply repair the tissue damage induced by catabolic factors, but play an important role in OA pathogenesis