School-Based Feeding Programs in Canada and Other Highly Developed Countries

Why should school-based feeding programs be less prevalent in Canada than in some other comparable countries? As educators, parents, and citizens, we would be disturbed if schools were to choose to omit Canadian history, English, or mathematics from their courses of study. Yet is not access to an adequate meal, especially at mid-day, an equally fundamental expectation? The main purpose of this thesis was to draft plausible explanations for the lack of well-developed school-based feeding programs in Canada. This goal was accomplished by investigating the development and operation of school- based feeding programs in selected countries and then comparing conditions and circumstances in those countries to the situation in Canada. The inquiry was guided by theoretical elements drawn from the literature on organizational theory and public policy. Descriptive data about school-based feeding programs were sought in the pertinent literature. Comparative analysis techniques were used to identify similarities and differences between provisions for, and the development of, school-based feeding programs in Canada and selected countries. The results of this investigation into the development and current status of school- based feeding programs in Canada and selected comparison countries support the initial claim that school-based feeding programs are indeed much less prevalent in Canada than the USA, UK, and Japan. Chapter One discusses the problem, research questions, theoretical framework, and research design adopted for the inquiry. Chapter Two presents a review of literature on school-based feeding programs and provides a summary of the status of school-based feeding programs in countries ranked high on the United Nation’s Human Development Index on which Canada is the highest-ranked nation. The development and operation of school-based feeding programs in Canada and the selected comparison countries are summarized in Chapters Three, Four, and Five. Chapter Six offers a comparative overview of structural, environmental, and political features associated with the school- based feeding programs in the comparison countries, together with a discussion of the presence, or absence, of similar conditions in Canada. Chapter Seven, begins with a review of the problem addressed in the thesis, followed by an in-depth discussion of the theoretical framework and research design adopted to guide the inquiry. The chapter ends with a discussion of the main conclusions and implications arising from the study, with reflections on prospects for the future of school- based feeding programs in Canada

Acceleration of Enterococcus faecalis Biofilm Formation by Aggregation Substance Expression in an Ex Vivo Model of Cardiac Valve Colonization

Infectious endocarditis involves formation of a microbial biofilm in vivo. Enterococcus faecalis Aggregation Substance (Asc10) protein enhances the severity of experimental endocarditis, where it has been implicated in formation of large vegetations and in microbial persistence during infection. In the current study, we developed an ex vivo porcine heart valve adherence model to study the initial interactions between Asc10+ and Asc10− E. faecalis and valve tissue, and to examine formation of E. faecalis biofilms on a relevant tissue surface. Scanning electron microscopy of the infected valve tissue provided evidence for biofilm formation, including growing masses of bacterial cells and the increasing presence of exopolymeric matrix over time; accumulation of adherent biofilm populations on the cardiac valve surfaces during the first 2–4 h of incubation was over 10-fold higher than was observed on abiotic membranes incubated in the same culture medium. Asc10 expression accelerated biofilm formation via aggregation between E. faecalis cells; the results also suggested that in vivo adherence to host tissue and biofilm development by E. faecalis can proceed by Asc10-dependent or Asc10-independent pathways. Mutations in either of two Asc10 subdomains previously implicated in endocarditis virulence reduced levels of adherent bacterial populations in the ex vivo system. Interference with the molecular interactions involved in adherence and initiation of biofilm development in vivo with specific inhibitory compounds could lead to more effective treatment of infectious endocarditis

Investigating the Direct and Indirect Effects of Forest Fragmentation on Plant Functional Diversity

Ongoing habitat loss and fragmentation alter the functional diversity of forests. Generalising the magnitude of change in functional diversity of fragmented landscapes and its drivers is challenging because of the multiple scales at which landscape fragmentation takes place. Here we propose a multi-scale approach to determine whether fragmentation processes at the local and landscape scales are reducing functional diversity of trees in the East Usambara Mountains, Tanzania. We employ a structural equation modelling approach using five key plant traits (seed length, dispersal mode, shade tolerance, maximum tree height, and wood density) to better understand the functional responses of trees to fragmentation at multiple scales. Our results suggest both direct and indirect effects of forest fragmentation on tree functional richness, evenness and divergence. A reduction in fragment area appears to exacerbate the negative effects resulting from an increased amount of edge habitat and loss of shape complexity, further reducing richness and evenness of traits related to resource acquisition and favouring tree species with fast growth. As anthropogenic disturbances affect forests around the world, we advocate to include the direct and indirect effects of forest fragmentation processes to gain a better understanding of shifts in functional diversity that can inform future management efforts

Development of the catecholamine innervation of the supraoptic nucleus in the Brattleboro rat

The ontogenetic development of the noradrenergic innervation of the supraoptic nucleus was studied in the Brattleboro rat at late postcoital and early postnatal ages. This genetic mutant offers a useful model for analysis of neuronal development because of the absence of a specific peptide component of identifiable target neurons and has been used presently to eliminate the possibility that such substances are essential for the establishment of normal connectivity during postnatal development. In this model, catecholamine varicosities were seen in juxtaposition to vasopressin-deficient perikarya during the initial phases of postnatal development, but these varicosities gradually decreased in number suggesting the possibility that the target neuron peptide, or some functional aspect of the neuron, may be necessary for the normal maintenance of this neuronal interaction.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24975/1/0000402.pd

Identification of Functionally Distinct Na-HCO3 Co-Transporters in Colon

Na-HCO3 cotransport (NBC) regulates intracellular pH (pHi) and HCO3 secretion in rat colon. NBC has been characterized as a 5,5′-diisothiocyanato-2-2′-stilbene (DIDS)-sensitive transporter in several tissues, while the colonic NBC is sensitive to both amiloride and DIDS. In addition, the colonic NBC has been identified as critical for pHi regulation as it is activated by intravesicular acid pH. Molecular studies have identified several characteristically distinct NBC isoforms [i.e. electrogenic (NBCe) and electroneutral (NBCn)] that exhibit tissue specific expression. This study was initiated to establish the molecular identity and specific function of NBC isoforms in rat colon. Northern blot and reverse transcriptase PCR (RT-PCR) analyses revealed that electrogenic NBCe1B or NBCe1C (NBCe1B/C) isoform is predominantly expressed in proximal colon, while electroneutral NBCn1C or NBCn1D (NBCn1C/D) is expressed in both proximal and distal colon. Functional analyses revealed that amiloride-insensitive, electrogenic, pH gradient-dependent NBC activity is present only in basolateral membranes of proximal colon. In contrast, amiloride-sensitive, electroneutral, [H+]-dependent NBC activity is present in both proximal and distal colon. Both electrogenic and electroneutral NBC activities are saturable processes with an apparent Km for Na of 7.3 and 4.3 mM, respectively; and are DIDS-sensitive with apparent Ki of 8.9 and 263.8 µM, respectively. In addition to Na-H exchanger isoform-1 (NHE1), pHi acidification is regulated by a HCO3-dependent mechanism that is HOE694-insensitive in colonic crypt glands. We conclude from these data that electroneutral, amiloride-sensitive NBC is encoded by NBCn1C/D and is present in both proximal and distal colon, while NBCe1B/C encodes electrogenic, amiloride-insensitive Na-HCO3 cotransport in proximal colon. We also conclude that NBCn1C/D regulates HCO3-dependent HOE694-insensitive Na-HCO3 cotransport and plays a critical role in pHi regulation in colonic epithelial cells

Measuring the water retention curve of rock fragments: A novel repacked core methodology

We describe a novel suction plate experiment that uses large, repacked soil cores comprising clasts and a fine-textured matrix to accurately measure the water retention curve of rock fragments (RFs) of high and low porosity. The method incorporates a suction plate-core containment system that can be weighed as a unit, to overcome typical core size restrictions. The method relies on analysing the relationship between total core volumetric water content and RF concentration. Cores are packed with a mix of glass and RFs to maintain a uniform volumetric total clast proportion of 30% while RF concentration varies. A constant total clast volume improves accuracy and precision by ensuring the water-holding characteristics of the matrix varies as little as possible among cores

Association between body mass index and response to duloxetine for aromatase inhibitor‐associated musculoskeletal symptoms in SWOG S1202

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149517/1/cncr32024.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149517/2/cncr32024_am.pd

A One Health overview, facilitating advances in comparative medicine and translational research.

Table of contentsA1 One health advances and successes in comparative medicine and translational researchCheryl StroudA2 Dendritic cell-targeted gorilla adenoviral vector for cancer vaccination for canine melanomaIgor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. CurielA3 Viroimmunotherapy for malignant melanoma in the companion dog modelJeffrey N. Bryan, David Curiel, Igor Dmitriev, Elena Kashentseva, Hans Rindt, Carol Reinero, Carolyn J. HenryA4 Of mice and men (and dogs!): development of a commercially licensed xenogeneic DNA vaccine for companion animals with malignant melanomaPhilip J. BergmanA5 Successful immunotherapy with a recombinant HER2-expressing Listeria monocytogenes in dogs with spontaneous osteosarcoma paves the way for advances in pediatric osteosarcomaNicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha, Margie Huebner, Yvonne PatersonA6 Human clinical development of ADXS-HER2Daniel O'ConnorA7 Leveraging use of data for both human and veterinary benefitLaura S. TremlA8 Biologic replacement of the knee: innovations and early clinical resultsJames P. StannardA9 Mizzou BioJoint Center: a translational success storyJames L. CookA10 University and industry translational partnership: from the lab to commercializationMarc JacobsA11 Beyond docking: an evolutionarily guided OneHealth approach to drug discoveryGerald J. Wyckoff, Lee Likins, Ubadah Sabbagh, Andrew SkaffA12 Challenges and opportunities for data applications in animal health: from precision medicine to precision husbandryAmado S. GuloyA13 A cloud-based programmable platform for healthHarlen D. HaysA14 Comparative oncology: One Health in actionAmy K. LeBlancA15 Companion animal diseases bridge the translational gap for human neurodegenerative diseaseJoan R. Coates, Martin L. Katz, Leslie A. Lyons, Gayle C. Johnson, Gary S. Johnson, Dennis P. O'BrienA16 Duchenne muscular dystrophy gene therapyDongsheng DuanA17 Polycystic kidney disease: cellular mechanisms to emerging therapiesJames P. CalvetA18 The domestic cat as a large animal model for polycystic kidney diseaseLeslie A. Lyons, Barbara GandolfiA19 The support of basic and clinical research by the Polycystic Kidney Disease FoundationDavid A. BaronA20 Using naturally occurring large animal models of human disease to enable clinical translation: treatment of arthritis using autologous stromal vascular fraction in dogsMark L. WeissA21 Regulatory requirements regarding clinical use of human cells, tissues, and tissue-based productsDebra A. WebsterA22 Regenerative medicine approaches to Type 1 diabetes treatmentFrancis N. KaranuA23 The zoobiquity of canine diabetes mellitus, man's best friend is a friend indeed-islet transplantationEdward J. RobbA24 One Medicine: a development model for cellular therapy of diabetesRobert J. Harman

Literator 2010: Daniel Kehlmann. Dozentur für Weltliteratur

"Sollen doch die Literaturwissenschaftler sich damit beschäftigen, etwas Übersehenes zu finden, der Literat aber darf sich auch einmal den Luxus erlauben, über das Beliebteste zu sprechen, also jenes weltgewinnende Werk, das für immer das Bild eines Kontinents verändert hat. Südamerika, so ließ García Márquez einst jemanden in seiner frühen Novelle Der Oberst hat niemand, der ihm schreibt klagen, das sei für die meisten Menschen doch nur ein Mann mit Schnurrbart, Gitarre und Pistole. Das stimmte dereinst sicher, aber heute ist Südamerika eher ein unheimliches Haus, umgeben von Moor und buntem Regenwald, ein Land bizarrer und melancholischer Wunder. Unsere Vorstellungen sind hier so sehr durch einen einzigen Roman geprägt, dass wir es kaum mehr bemerken." Daniel Kehlman