Malignant Scalp Tumors: Retrospective Analysis of 1000 Patients.

Abstract Background: Limited data on large cohort of patients with malignant tumors of the scalp are available in the literature. e aim of this study was to review a large cohort of patients with malignant scalp tumors to determine epidemilogy, tumor characteristics of this region and treatment. Materials and Method: A retrospective review of patients with malignant scalp tumors diagnosed histopathologically between 2005 and 2021 was performed. Demographic features and tumor characteristics were analyzed. Results: A total of 1080 patients (M: F 3,5:1) were treated and followed up for a mean period of 42 months (12-120 months). Age at diagnosis ranged from 12 to 98 years. Most malignant scalp tumors (95,1%) occurred in those 50 years or older and in bald patients (87%). Basal cell carcinomas (59,2%), squamous cell carcinomas (32,2%) and melanomas were the most common histologic types. Incidence was highest on the frontal of temporal region (66,1%). Recurrence was frequently in squamous and basal cell carcinomas but uncommon in melanoma. Conclusions: Tumors of the scalp accounted about 8,01 % of all skin cancers. Tend to be basal and squamous cell carci- nomas, many of which occur in the temporal and frontal region of bald men. e outlook for patients with scalp tumor is positive, although we suggest excision margins of at least 3-4 mm and continued clinical vigilance is warranted given their higher recurrence rates. MLN: Melanom

Marine geomagnetic high definition metrology; possible archaeological applications

The marine geomagnetism is often used to solve geological problems at a regional scale: structural, volcanological or mining problems, for instance (Faggioni et al., 1995). In recent time, the development of the “high definition (HD) metrology” (Faggioni et al., 2001) has made the marine geomagnetic method suitable for detecting short wavelength and low amplitude geomagnetic anomalies. This type of signal may be often related to environmental and/or archaeological sources......

High-resolution marine magnetic surveys for searching underwater cultural resources

Recently two marine magnetic surveys, combined with the use of a multi-beam sonar (Kongsberg Marittime EM 300 multibeam: 30 KHz frequency echosounder for hydrographic purposes; acoustic lobe composed of 128 beams able to cover a 150° sector) a side-scan sonar (Simrad MS 992 dual-frequency sidescan sonar with echo sounder transducers 150 Hz and 330 KHz) and a Remote Operated Vehicle (ROV – a mobile tools used in environments which are too dangerous for humans), were executed in two sites respectively in the Ligurian Sea and the Asinara Gulf. The aim of these investigations was to test modern instrumentations and set new working procedures for searching underwater cultural resources. The collected and processed magnetic data yielded very satisfactory results: we detected submerged and buried features of cultural interest at both sites, at depths of 40 m and 400 m respectively

Freestyle-Like V-Y Flaps of the Eyebrow: A New Outlook and Indication of an Historical Technique

The eyebrow region is of utmost importance for facial movement, symmetry, and the overall cosmetic appearance of the face. Trauma or tumor resection often leave scars that may dislocate the eyebrow producing an alteration both in static symmetry of the face and in the dynamic expressivity. The authors present a technique for eyebrow's defects repair using the remaining eyebrow advancement by means of a "freestyle-like" V-Y flap. In the past two years a total of eight consecutive patients underwent excision of skin lesions in the superciliary region and immediate reconstruction with this technique. On histology, six patients were affected from basal cell carcinomas, one from squamous cell carcinoma, and one from congenital intradermal melanocytic nevus. The pedicle of the flap included perforators from the supratrochlear, supraorbital, or superficial temporalis artery. Advancement of the entire aesthetic subunit that includes the eyebrow using a V-Y perforator flap was performed successfully in all cases achieving full, tension-free closure of defects up to 3.0\u2009cm. "Freestyle-like" V-Y flaps should be considered as a first-line choice for partial defects of the eyebrow. The greater mobility compared to random subcutaneous flaps allows to reconstruct large defects providing an excellent cosmetic result

Multidisciplinary Investigations at Panarea (Aeolian Islands) after the Exhalative Crisis of 2002

Panarea and surrounding Islets form a volcanic edifice, that is part of the Eastern sector of the Aeolian Arc, Southern Tyrrhenian Sea. It is now considered inactive, since last documented activity is 20 Ka old. However, on 2002-11-03, gas started to flow violently from the seafloor in an area E of the Island, mainly along NE and NW structural lineaments, and lasting up to 2003-2004 with a consistent flux, orders of magnitude larger that ’steady-state’ fumarolic activity documented there in historical times. On the same period a strong effusive activity of Stromboli (10 NM to NNE) was present. Since then, several investigations have been conducted at sea and on land, with the aim of focusing on the problem of effusive activity at sea, mainly in the light of volcanic surveillance and risk. Among these investigations, some of which have been repeated over years, we present and discuss some data and results from: (a)visual inspection and sampling by divers and ROV, (b)GPS networks and mapping by multibeam and LIDAR, (c) oceanographical measurements by current meters and CTD, and water flux and dynamics measurements, (d)magnetic and gravimetric surveys, (e) multichannel reflection Seismic with OBS and land station networks. Data were used for compilation of high resolution bathymetric, magnetic and gravimetric maps, including the emerged and submerged portions of the edifice

“ALLA SCOPERTA dei TESORI del MARE” - Scienza e Tecnologia, Memoria Popolare e Identità Culturale di una città della costa ligure

“Il dovere degli scienziati non è quello di educare il pubblico, ma piuttosto di interagire con esso. Il pubblico è la vera forza trainante dietro decisioni con conseguenze sociali, e deve essere coinvolto su base paritaria nei dibattiti inerenti queste decisioni” . La comunicazione scientifica e tecnologica fra scienza e società, da anni, non è più un mero scambio di informazioni e risultati (spesso fra determinate élite), ma è diventata il veicolo privilegiato per insegnare, formare ed ispirare un pubblico sempre più ampio. Ma non si parla solo di trasmissione uni-direzionale: il dibattito fra scienza, tecnologia e società (amministratori locali, politici, imprenditori, giornalisti, studenti e semplici cittadini) sta guadagnando una partecipazione di interlocutori sempre più numerosi e preparati su temi dalle complesse caratteristiche ed implicazioni (etiche, sociali, economiche, politiche). Questo è in parte dovuto ai cambiamenti avvenuti negli ultimi anni nella scienza (e all’impatto che essa sta avendo in molti ambiti della vita sociale. Tali cambiamenti stanno determinando nuove forme di comunicazione scientifica e cooperazione con la società e l’aumento, nell’ultimo decennio, di iniziative e percorsi di formazione, spesso organizzati dalle stesse istituzioni scientifiche. Uno dei risultati più tangibili della cambiata interazione fra scienza e società è la nuova generazione di ricercatori-comunicatori, dotati di una maggiore abilità nel comunicare la scienza in modo efficace e ad un pubblico più ampio e diversificato. In questo contesto diventa importante capire l’efficacia di ogni azione di comunicazione scientifica, impostando uno studio che analizzi, volta per volta, i punti di successo e le criticità emerse nei due comparti causa-effetto. Causa – gli elementi di base della comunicazione scientifica e tecnologica:  i valori sociali e culturali di riferimento (ad es. protezione ambientale, sicurezza, salute); - i contenuti (formato di presentazione, tematiche scelte); - i canali usati (web, social networks, stampa cartacea etc.); - i modelli di relazione con il pubblico (scienza vs pubblico, peer education). Effetto - la risposta della società:  diretta (affluenza; questionari di gradimento)  indiretta (visualizzazioni web; like se tweet dei social network). Questo lavoro presenta una relazione illustrativa (per la prima volta sul territorio della Spezia) dell’efficacia di un evento specifico inserito all’interno di una manifestazione di portata locale, la “Festa della Marineria 2013 ”, destinato al grande pubblico e caratterizzato da diverse attività (tra le quali quelle di tipo ludico-educativo) concepite con l’obiettivo di puntare l’attenzione sui ‘tesori’ scientifici e culturali di una ‘Città di Mare’qual'è La Spezia

SAS multipass interferometry for monitoring seabed deformation using a high-frequency imaging sonar

Abstract-. This paper presents the results of a two years project led and funded by Eni from 2008 to 2010 with the aim of supporting the development and experimentation of innovative technology for environmental monitoring. The problem addressed is the precise estimate of possible altimetric variations of the seabed through long-term monitoring. The selected methodology consists in the application of repeat-track interferometry to high-resolution, high-frequency sonar data collected from an AUV during repeated surveys of a seafloor area of interest. The paper describes the experimental measurements conducted at sea, the SAS and interferometry methodologies developed, and the results obtained on artificial objects sitting on the seabed. The quality of the achieved focusing is analyzed. The achieved repeat-pass SAS interferograms are shown and analyzed. The coherence along time of the particular kind of seabed (silty sand) characterizing the experimental area is presented and the utility of artificial reflectors for long-term SAS interferometry is discussed.Published673-6832.5. Laboratorio per lo sviluppo di sistemi di rilevamento sottomariniN/A or not JCRreserve

Some magnetic evidences of the Ist century BC Salapia harbor near the Margherita di Savoia shoreline, SE Italy

This paper highlights some magnetic evidences revealed by a recent marine magnetic survey ran near the Margherita di Savoia shoreline, Puglia (Italy). The survey has been planned to probe one of the expected settlement site not perused yet. The accurate elaboration of high density total magnetic field intensity data shows some features which can be interpreted as markers of harbor framework, at present time partially uprooted. A model of the bodies which cause the magnetic anomaly is also provided

High-resolution marine magnetic surveys for searching underwater cultural resources

Recently two marine magnetic surveys, combined with the use of a multi-beam sonar (Kongsberg Marittime EM 300 multibeam: 30 KHz frequency echosounder for hydrographic purposes; acoustic lobe composed of 128 beams able to cover a 150° sector) a side-scan sonar (Simrad MS 992 dual-frequency sidescan sonar with echo sounder transducers 150 Hz and 330 KHz) and a Remote Operated Vehicle (ROV – a mobile tools used in environments which are too dangerous for humans), were executed in two sites respectively in the Ligurian Sea and the Asinara Gulf. The aim of these investigations was to test modern instrumentations and set new working procedures for searching underwater cultural resources. The collected and processed magnetic data yielded very satisfactory results: we detected submerged and buried features of cultural interest at both sites, at depths of 40 m and 400 m respectively

Application of the Meet-URO score to metastatic renal cell carcinoma patients treated with second- and third-line cabozantinib

Background: The addition of neutrophil-to-lymphocyte ratio (NLR) and bone metastases to the International Metastatic RCC Database Consortium (IMDC) score (by the Meet-URO score) has been shown to better stratify pretreated metastatic renal cell carcinoma (mRCC) patients receiving nivolumab. This study aimed to validate the Meet-URO score in patients receiving cabozantinib to assess its predictivity and prognostic role. Methods: A multicenter retrospective analysis evaluated mRCC patients receiving ⩾second-line cabozantinib. NLR, IMDC score and bone metastases were assessed before the start of cabozantinib. The primary endpoint was overall survival (OS). Harrell’s c-index was calculated to compare the accuracy of the prediction of the two scores. Results: Overall, 174 mRCC patients received cabozantinib as second and third line (51.7% and 48.3%, respectively) with a median follow-up of 6.8 months. A shorter median overall survival (mOS) was observed for the IMDC poor-risk group, NLR ⩾3.2 and the presence of bone metastases, while the IMDC intermediate-risk group had a similar mOS to the favourable-risk one. Applying the Meet-URO score, three risk groups were identified: group 1 (55.2% of patients) with a score of 0–3, group 2 (38.5%) with a score of 4–8 and group 3 (6.3%) with a score of 9. Compared to group 1 (mOS: 39.4 months), a statistically significant worse mOS was observed in group 2 (11.2 months) and group 3 (3.2 months) patients, respectively. The Meet-URO c-index score was 0.640, showing a higher discriminative ability than the IMDC score (c-index: 0.568). Conclusion: This analysis showed that the Meet-URO score provides a more accurate prognostic stratification than the IMDC score in mRCC patients treated with ⩾second-line cabozantinib besides nivolumab. Moreover, it is an easy-to-use tool with no additional costs for clinical practice (web-calculator is available at: https://proviso.shinyapps.io/Meet-URO15_score/). Future investigations will include the application of the Meet-URO score to the first-line immunotherapy-based combination therapies