Analysis of Vesicular Basalts and Lava Emplacement Processes for Application as a Paleobarometer/Paleoaltimeter

We have developed a method for determining paleoelevations of highland areas on the basis of the vesicularity of lava flows. Vesicular lavas preserve a record of paleopressure at the time and place of emplacement because the difference in internal pressure in bubbles at the base and top of a lava flow depends on atmospheric pressure and lava flow thickness. At the top of the flow, the pressure is simply atmospheric pressure, while at the base, there is an additional contribution of hydrostatic lava overburden. Thus the modal size of the vesicle (bubble) population is larger at the top than at the bottom. This leads directly to paleoatmospheric pressure because the thickness of the flow can easily be measured in the field, and the vesicle sizes can now be accurately measured in the lab. Because our recently developed technique measures paleoatmospheric pressure, it is not subject to uncertainties stemming from the use of climate‐sensitive proxies, although like all measurements, it has its own sources of potential error. Because measurement of flow thickness presupposes no inflation or deflation of the flow after the size distribution at the top and bottom is “frozen in,” it is essential to identify preserved flows in the field that show clear signs of simple emplacement and solidification. This can be determined by the bulk vesicularity and size distribution as a function of stratigraphic position within the flow. By examining the stratigraphic variability of vesicularity, we can thus reconstruct emplacement processes. It is critical to be able to accurately measure the size distribution in collected samples from the tops and bottoms of flows because our method is based on the modal size of the vesicle population. Previous studies have used laborious and inefficient methods that did not allow for practical analysis of a large number of samples. Our recently developed analytical techniques involving high‐resolution x‐ray computed tomography (HRXCT) allow us to analyze the large number of samples required for reliable interpretations. Based on our ability to measure vesicle size to within 1.7% (by volume), a factor analysis of the sensitivity of the technique to atmospheric pressure provides an elevation to within about ±400 m. If we assume sea level pressure and lapse rate have not changed significantly in Cenozoic time, then the difference between the paleoelevation “preserved” in the lavas and their present elevation reflects the amount of uplift or subsidence. Lava can be well dated, and therefore a suite of samples of various ages will constrain the timing of epeirogenic activity independent of climate, erosion rates, or any other environmental factors. We have tested our technique on basalts emplaced at known elevations at the base, flanks, and summit of Mauna Loa. The results of the analysis accurately reconstruct actual elevations, demonstrating the applicability of the technique. The tool we have developed can subsequently be applied to problematic areas such as the Colorado and Tibetan Plateaus to determine the history of uplift

The Process of Observing Oral Reading Scores

Oral reading has a varied history of interpretation (12) and IS presently under scrutiny in terms of characteristics rather than quantity (5). Despite the doubt that controversies generate, the identification and tabulation of oral reading errors dominate decisions generated in practice us,ing informal reading inventories. In practice, informal reading inventories depend on identification, scoring, and interpretation of oral reading errors. Controversies are usually ignored perhaps in the hope that the expert judgment of reading specialists overcomes the difficulties. Beldin (1) explores the controversial history of informal inventories. From early studies to the present, doubt surrounds scoring criteria ( 7, 9, 10). This study examines the process of identification and scoring of oral reading errors by well-qualified reading specialists

Semiclassical Gravity in the Far Field Limit of Stars, Black Holes, and Wormholes

Semiclassical gravity is investigated in a large class of asymptotically flat, static, spherically symmetric spacetimes including those containing static stars, black holes, and wormholes. Specifically the stress-energy tensors of massless free spin 0 and spin 1/2 fields are computed to leading order in the asymptotic regions of these spacetimes. This is done for spin 0 fields in Schwarzschild spacetime using a WKB approximation. It is done numerically for the spin 1/2 field in Schwarzschild, extreme Reissner-Nordstrom, and various wormhole spacetimes. And it is done by finding analytic solutions to the leading order mode equations in a large class of asymptotically flat static spherically symmetric spacetimes. Agreement is shown between these various computational methods. It is found that for all of the spacetimes considered, the energy density and pressure in the asymptotic region are proportional to 1/r^5 to leading order. Furthermore, for the spin 1/2 field and the conformally coupled scalar field, the stress-energy tensor depends only on the leading order geometry in the far field limit. This is also true for the minimally coupled scalar field for spacetimes containing either a static star or a black hole, but not for spacetimes containing a wormhole.Comment: 43 pages, 2 figures. Reference added, minor changes, PRD versio

Harnessing the BMP signaling pathway to control the formation of cancer stem cells by effects on epithelial-to-mesenchymal transition

Cancer stem cells (CSCs) persist in tumors as a distinct population and may be causative in metastasis and relapse. CSC-rich tumors are associated with higher rates of metastasis and poor patient prognosis. Targeting CSCs therapeutically is challenging, since they seem to be resistant to standard chemotherapy. We have shown that a novel peptide agonist of bone morphogenetic protein (BMP) signaling, P123, is capable of inhibiting the growth of primary tumor cells by interacting with type I receptors selectively [activin receptor-like kinase 2 (ALK2) and ALK3, but not ALK6] and type II BMP receptors, activating SMAD 1/5/8 signaling and controlling the cell cycle pathway. Furthermore, the compound is capable of blocking transforming growth factor-β induced epithelialto-mesenchymal transition (EMT) in primary tumor cells, a critical step for tumor progression and metastasis. In addition, we have investigated the effects of P123 on self-renewal, growth, differentiation (reversal of EMT) and apoptosis of isolated human breast CSCs. We have shown that P123 and BMP-7 reverse the EMT process in human breast CSCs, and inhibit self-renewal and growth. Moreover, compared with single treatment with paclitaxel, co-treatment with paclitaxel and P123 showed an increase in cell apoptosis. Together, these findings suggest that P123 has the therapeutic potential to suppress both bulk tumor cells and CSCs. We believe that P123 represents a new class of drugs that have the potential to eliminate the primary tumor, prevent reoccurrence and metastasis, and enhance the treatment of breast cancer. Prostate and breast cancer represent two of the most prevalent cancers for men and women. Overall, one in six men will be diagnosed with prostate cancer and one in eight women will develop breast cancer in their lifetime. An estimated 220 000 men and 230 000 women were diagnosed with prostate cancer and breast cancer in 2015. Primary prostate cancer has an excellent prognosis with a 100% fiveyear survival rate. Metastatic disease, however, carries a very poor prognosis with a five-year survival of only 28%. Similarly, in early-stage breast cancer, prognosis is excellent with a five-year survival of 98%. Metastatic disease carries a much higher mortality with a five-year survival rate of only 26% [1]. Conventional treatment for these cancers primarily targets bulk tumor cells. It is now understood that in the majority of patients, there is a population of cancer cells that have acquired a drug-resistant phenotype [2]. This population of cells that survive after standard therapies is thought to give rise to metastasis and lead to tumor recurrenc

Neurogenesis Deep Learning

Neural machine learning methods, such as deep neural networks (DNN), have achieved remarkable success in a number of complex data processing tasks. These methods have arguably had their strongest impact on tasks such as image and audio processing - data processing domains in which humans have long held clear advantages over conventional algorithms. In contrast to biological neural systems, which are capable of learning continuously, deep artificial networks have a limited ability for incorporating new information in an already trained network. As a result, methods for continuous learning are potentially highly impactful in enabling the application of deep networks to dynamic data sets. Here, inspired by the process of adult neurogenesis in the hippocampus, we explore the potential for adding new neurons to deep layers of artificial neural networks in order to facilitate their acquisition of novel information while preserving previously trained data representations. Our results on the MNIST handwritten digit dataset and the NIST SD 19 dataset, which includes lower and upper case letters and digits, demonstrate that neurogenesis is well suited for addressing the stability-plasticity dilemma that has long challenged adaptive machine learning algorithms.Comment: 8 pages, 8 figures, Accepted to 2017 International Joint Conference on Neural Networks (IJCNN 2017

Canopy Interception of Acid Deposition in Southern Ontario

The impact of tree canopies on acid deposition was examined. Differences in the chemical composition of unintercepted precipitation (dustfall) and canopy was intercepted precipitation (throughfall) at 18 southern Ontario forests, collected during the summers of 1995-1996, were chemically analyzed. The methodology of collection and analysis validated using consistency checks for interception loss, maintenance of electrical neutrality and ion correlation. T-test analyses found throughfall fluxes of K+, Ca2+, Mg2+, and NO3- were significantly higher than dustfall flux (p < 0.05), consistent with other studies. Barrie and nearby sites at Orillia and Bracebridge had larger dustfall depositions of base cations and Cl- suggesting a nearby source of these ions. T-tests revealed large exceedances of pH and sulphate concentration in dustfall over throughfall at the two Scarborough sites; a local point source of sulphates in the Greater Toronto Area was suspected

Lithium in garnet as a tracer of subduction zone metamorphic reactions: The record in ultrahigh-pressure metapelites at Lago di Cignana, Italy

Lithium is of great interest as a tracer of metamorphic reactions and related fluid-mineral interactions because of its potential to isotopically fractionate during inter- and intracrystalline diffusional processes. Study of its transfer through subduction zones, based on study of arc volcanic and metamorphic rocks, can yield insight regarding ocean-to-mantle chemical cycling. We investigated major- and trace-element concentrations and delta Li-7 in garnet in ultrahigh-pressure (UHP) Lago di Cignana metasedimentary rocks, relating these observations to reconstructed prograde devolatilization history. In all garnet crystals we studied, heavy rare earth elements (HREEs), Y, and Li showed strong zoning, with elevated concentrations in cores (15-50 ppm Li) and marked high-concentration anomalies (up to 117 ppm Li, 5500 ppm Y; little or no major-element shift) as growth annuli, in which some crystals showed subtle elevation in delta Li-7 greater than analytical error of similar to 3 parts per thousand (2 sigma). Rutile inclusions appeared abruptly at annuli and outward toward rims, accompanied by inclusions of a highly zoned, Ca- and rare earth element-rich phase and decreased Nb concentrations in garnet. These relationships are interpreted to reflect prograde garnet-forming reaction(s), in part involving titanite breakdown to stabilize rutile, which resulted in delivery of more abundant Y and HREEs at surfaces of growing garnet crystals to produce annuli. Co-enrichments in Li and Y + REEs are attributed to mutual incorporation via charge-coupled substitutions; thus, increased Li uptake was a passive consequence of elevated concentrations of Y + REEs. The small-scale fluctuations in delta Li-7 (overall range of similar to 9 parts per thousand) observed in some crystals may correlate with abrupt shifts in major-and trace-element concentrations, suggesting that changes in reactant phases exerted some control on the evolution of delta Li-7. For one garnet crystal, late-stage growth following partial resorption produced deviation in major- and trace-element compositions, including Li concentration, accompanied by a 10 parts per thousand-15 parts per thousand negative shift in delta Li-7, perhaps reflecting a change in the mechanism of incorporation or source of Li. These results highlight the value of measuring the major- and trace-element and isotope compositions of garnets in high-pressure and UHP metamorphic rocks in which matrix mineral assemblages are extensively overprinted by recrystallization during exhumation histories. Lithium concentrations and isotope compositions of the garnets can add valuable information regarding prograde (and retrograde) reaction history, kinetics of porphyroblast growth, intracrystalline diffusion, and fluid-rock interactions. This work, integrated with previous study of devolatilization in the Schistes Lustres/Cignana metasedimentary suite, indicates retention of a large fraction of the initially subducted sedimentary Li budget to depths approaching those beneath volcanic fronts, despite the redistribution of this Li among mineral phases during complex mineral reaction histories

Stress-Energy Tensor for the Massless Spin 1/2 Field in Static Black Hole Spacetimes

The stress-energy tensor for the massless spin 1/2 field is numerically computed outside and on the event horizons of both charged and uncharged static non-rotating black holes, corresponding to the Schwarzschild, Reissner-Nordstrom and extreme Reissner-Nordstr\"om solutions of Einstein's equations. The field is assumed to be in a thermal state at the black hole temperature. Comparison is made between the numerical results and previous analytic approximations for the stress-energy tensor in these spacetimes. For the Schwarzschild (charge zero) solution, it is shown that the stress-energy differs even in sign from the analytic approximation. For the Reissner-Nordstrom and extreme Reissner-Nordstrom solutions, divergences predicted by the analytic approximations are shown not to exist.Comment: 5 pages, 4 figures, additional discussio