Goodness of fit in optimizing consumer's model

We provide two new indices of efficiency for determining the degree of coherence in an agent's consumption decisions. We analyze to which extent they improve the efficiency displayed by Varian's (Journal of Econometrics, 1990) index. We report on the results of a Montecarlo experiment that confirms that strict improvements of Varian's vector-index appear on a regular basis.Consumer behavior; GARP; revealed preference; goodness of fit

Goodness of fit in optimizing consumer's model

We provide two new indices of efficiency for determining the degree of coherence in an agent's consumption decisions. We analyze to which extent they improve the efficiency displayed by Varian's (Journal of Econometrics, 1990) index. We report on the results of a Montecarlo experiment that confirms that strict improvements of Varian's vector-index appear on a regular basis

Network Biology Identifies Novel Regulators of CFTR Trafficking and Membrane Stability

Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31231217/In cystic fibrosis, the most common disease-causing mutation is F508del, which causes not only intracellular retention and degradation of CFTR, but also defective channel gating and decreased membrane stability of the small amount that reaches the plasma membrane (PM). Thus, pharmacological correction of mutant CFTR requires targeting of multiple cellular defects in order to achieve clinical benefit. Although small-molecule compounds have been identified and commercialized that can correct its folding or gating, an efficient retention of F508del CFTR at the PM has not yet been explored pharmacologically despite being recognized as a crucial factor for improving functional rescue of chloride transport. In ongoing efforts to determine the CFTR interactome at the PM, we used three complementary approaches: targeting proteins binding to tyrosine-phosphorylated CFTR, protein complexes involved in cAMP-mediated CFTR stabilization at the PM, and proteins selectively interacting at the PM with rescued F508del-CFTR but not wt-CFTR. Using co-immunoprecipitation or peptide-pull down strategies, we identified around 400 candidate proteins through sequencing of complex protein mixtures using the nano-LC Triple TOF MS technique. Key candidate proteins were validated for their robust interaction with CFTR-containing protein complexes and for their ability to modulate the amount of CFTR expressed at the cell surface of bronchial epithelial cells. Here, we describe how we explored the abovementioned experimental datasets to build a protein interaction network with the aim of identifying novel pharmacological targets to rescue CFTR function in cystic fibrosis (CF) patients. We identified and validated novel candidate proteins that were essential components of the network but not detected in previous proteomic analyses.This work was supported by FCT, Portugal, through center grant UID/MULTI/04046/2019 to BioISI and the BioSys PhD program PD65-2012 (fellowships SFRH/BD/52488/2014, SFRH/ BD/106084/2015, and SFRH/BD/52490/2014 to CL, JS, and AM, respectively).info:eu-repo/semantics/publishedVersio

Combination of coagulation–flocculation–decantation and ozonation processes for winery wastewater treatment

This research assessed a novel treatment process of winery wastewater, through the application of a chemical-based process aiming to decrease the high organic carbon content, which represents a difficulty for wastewater treatment plants and a public health problem. Firstly, a coagulation–flocculation–decantation process (CFD process) was optimized by a simplex lattice design. Afterwards, the efficiency of a UV-C/ferrous iron/ozone system was assessed for organic carbon removal in winery wastewater. This system was applied alone and in combination with the CFD process (as a pre- and post-treatment). The coagulation–flocculation–decantation process, with a mixture of 0.48 g/L potassium caseinate and 0.52 g/L bentonite at pH 4.0, achieved 98.3, 97.6, and 87.8% removals of turbidity, total suspended solids, and total polyphenols, respectively. For the ozonation process, the required pH and ferrous iron concentration (Fe2+) were crucial variables in treatment optimization. With the application of the best operational conditions (pH = 4.0, [Fe2+] = 1.0 mM), the UV-C/ferrous iron/ozone system achieved 63.2% total organic carbon (TOC) removal and an energy consumption of 1843 kWh∙m−3∙order−1. The combination of CFD and ozonation processes increased the TOC removal to 66.1 and 65.5%, respectively, for the ozone/ferrous iron/UV-C/CFD and CFD/ozone/ferrous iron/UV-C systems. In addition, the germination index of several seeds was assessed and excellent values (>80%) were observed, which revealed the reduction in phytotoxicity. In conclusion, the combination of CFD and UV-C/ferrous iron/ozone processes is efficient for WW treatment.NORTE 2020 | Ref. NORTE-01-0145-FEDER-000041Fundação para a Ciência e a Tecnologia | Ref. UIDB/00616/2020Fundação para a Ciência e a Tecnologia | Ref. FCT-IF/00802/201

Late Strunian age : a key time frame for VMS deposit exploration in the Iberian Pyrite Belt

Estimate of geological environments favorable for the formation of massive sulphide deposits is an important goal to the exploration companies working in the Iberian Pyrite Belt (IPB), the main European VMS base metals province, with giant deposits such as Neves Corvo, Aljustrel (Portugal), Rio Tinto and Tharsis (Spain). Palynostratigraphic research programs using more than 40 exploration boreholes (>30 km length) allowed the dating of the sediments of the Volcano-Sedimentary Complex (upper Devonian to upper Viséan), that host the massive sulphide deposits. Research is based on detailed palynomorphs study. Careful work was focused on dark grey and black shale units that host stockwork and massive ore mineralizations. Felsic volcanic U/Pb age data was also used to confirm the sediment age.Late Strunian (miospore biozone LN, 360.7 ± 0.7 Ma -362 Ma) sediments host the massive sulphide ore at Neves Corvo, Lousal, Caveira and Montinho, mines located in the Portuguese IPB sector. In Spain similar data was obtained at Aznalcollar and Tharsis. The agedata show a favourable geological period of ~2 Ma were paleogeographic conditions were extremely favorable to hydrothermal fluid circulation and VMS deposits formation. Late Strunian age therefore becomes one key exploration guide in IPB

Geology of the Rosário-Neves Corvo antiform, Iberian Pyrite Belt, Portugal : new insights from physical volcanology, palynostratigraphy and isotope geochronology studies

The lithostratigraphic sequence in the Rosário–Neves Corvo antiform comprises the Phyllite–Quartzite Group, whose top is of Famennian age, the Volcanic Sedimentary Complex, of Strunian to upper Visean age, and the Mértola Formation (the lower unit of the Baixo Alentejo Flysch Group) of upper Visean age. The volcanic sedimentary complex comprises a lower sequence of Strunian (Late Famennian) age and an upper sequence of lower to upper Visean age. Detailed mapping of the antiform towards NW of the Neves Corvo mine, supported by palynological dating, identified two new lithostratigraphic units: the Barrancão member (upper Famennian) ascribed to the Phyllite–Quartzite Group and made up of laminated dark shales with siliceous lenses and nodules, and the Ribeira de Cobres Formation of the Volcanic Sedimentary Complex, containing shales, siltstones and fine volcaniclastic rocks. Based on zircon U–Pb isotope dating, five discrete felsic magmatic events were identified at approximately 354, 359, 365, 373 and 384 Ma. This suggests that the volcanic activity in the area has extended for about 30 Ma, in a context of high regional heat flow as indicated by the geochemical signatures of the felsic volcanic rocks. The characteristics of magmatism and the depositional environment indicated by the sedimentary record should therefore have been highly favourable for massive sulphide formation. However, evidence of massive sulphide mineralization in the study area is still to be found. Moreover, reconstruction of the volcanic facies architecture demonstrated that the volcanic units in the Rosário area are strongly dominated by coherent facies typical of the inner part of thick lavas/domes. In fact, most of their external part, the more favourable location for possible massive sulphide mineralization, is missing. Palynological dating indicates a significant hiatus, recognised between the lower and upper sequences of the volcanic sedimentary complex, which implies erosion of the top of the volcanic centre, where VHMS deposits could possibly have formed. However, lateral areas of this volcanic centre, eventually preserved at depth, have good potential to host massive sulphide mineralization

An autonomous intelligent gateway infrastructure for in-field processing in precision viticulture

Article in PressWireless sensor networks have found multiple applications in precision viticulture. Despite the steady progress in sensing devices and wireless technologies, some of the crucial items needed to improve the usability and scalability of the networks, such as gateway infrastructures and in-field processing, have been comparatively neglected. This paper describes the hardware, communication capabilities and software architecture of an intelligent autonomous gateway, designed to provide the necessary middleware between locally deployed sensor networks and a remote location within the whole-farm concept. This solar-powered infrastructure, denoted by iPAGAT (Intelligent Precision Agriculture Gateway), runs an aggregation engine that fills a local database with environmental data gathered by a locally deployed ZigBee wireless sensor network. Aggregated data are then retrieved by external queries over the built-in data integration system. In addition, embedded communication capabilities, including Bluetooth, IEEE 802.11 and GPRS, allow local and remote users to access both gateway and remote data, as well as the Internet, and run site-specific management tools using authenticated smartphones. Field experiments provide convincing evidence that iPAGAT represents an important step forward in the development of distributed service-oriented information systems for precision viticulture applications.The authors would like to acknowledge the Portuguese Foundation of Science and Technology (FCT), and Spanish Seneca Foundation Centre for Research Coordination that partially sponsors this research work through the scholarships references SFRH/BD/38759/2007 and 02998-PI-05, respectively