Cell-cell communication between Mouse mammary epithelial cells and 3T3-L1 preadipocytes: effect on triglyceride accumulation and cell proliferation

Interaction between parenchyma and stroma is essential for organogenesis, morphogenesis, and differentiation. Mammary gland has being the chosen model for developmental biologist because the most striking changes in morphology and function take place after birth. We have demonstrated a regulation of triglyceride accumulation by protein factors synthesized by normal mouse mammary gland epithelial cells (NMMG), acting on a cell line, 3T3-L1, long used as a model for adipogenesis. In this paper, we demonstrate that this inhibitory effect seems to be shared by other cells of epithelial origin but not by other cell types. We found a regulation of cell proliferation when NMMG cells are cultured in the presence of conditioned media from Swiss 3T3 or 3T3-L1 cells. We found a possible point of regulation for the mammary factor on a key enzyme of the lipid metabolic pathway, the glycerol-3-phosphate dehydrogenase. The inhibitory factor seems to have an effect on this enzyme´s activity and reduces it. The results presented herein contribute to the understanding of cell-cell communication in a model of a normal mammary gland.Fil: Julianelli, Vanina Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guerra, Liliana Noemi. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Calvo, Juan Carlos. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Labor Productivity, Capital Accumulation, and Aggregate Efficiency Across Countries: New Evidence for an Old Debate

This article studies the proximate sources of labor productivity differences across countries. Using a panel dataset for 74 countries covering the 1960-2010 period, it first documents that, relative to the US, labor productivity of the median country has been mostly stagnant, while cross-country disparities have drastically increased. Next, through the lens of a production function framework, it evaluates the proximate sources of labor productivity: physical capital, human capital, and aggregate efficiency. Results show stagnation and increasing disparities in physical capital, growth and decreasing disparities in human capital, and decline and increasing disparities in aggregate efficiency. By including the commonly unaccounted covariance between capital and aggregate efficiency into the analysis, disparities in aggregate efficiency explain most of the disparities in labor productivity across countries

Labor Productivity, Capital Accumulation, and Aggregate Efficiency Across Countries: New Evidence for an Old Debate

This article studies the proximate sources of labor productivity differences across countries. Using a panel dataset for 74 countries covering the 1960-2010 period, it first documents that, relative to the US, labor productivity of the median country has been mostly stagnant, while cross-country disparities have drastically increased. Next, through the lens of a production function framework, it evaluates the proximate sources of labor productivity: physical capital, human capital, and aggregate efficiency. Results show stagnation and increasing disparities in physical capital, growth and decreasing disparities in human capital, and decline and increasing disparities in aggregate efficiency. By including the commonly unaccounted covariance between capital and aggregate efficiency into the analysis, disparities in aggregate efficiency explain most of the disparities in labor productivity across countries

Cartographic records in the 1878 General Reforestation Reports: forest and agronomic sketches and drafts

Las Memorias Generales de Repoblación surgen con las disposiciones que desarrollan la Ley de 11 de julio de 1877 sobre repoblación, fomento y mejora de los montes públicos. Elaboradas por el personal de los distritos forestales, se envían al Ministerio de Fomento entre 1878 y 1884. Además de contener los objetivos y las actuaciones repobladoras propuestas por cada distrito, también reflejan, desde el punto de vista de los ingenieros del ramo, la situación de los montes españoles e incluyen en ocasiones, dentro de esta lógica descriptiva, una cartografía básica de contenido forestal, agronómico y geológico. Ésta es conocida en unos pocos casos a través de los originales publicados a mayor escala; pero en otros no se tenía constancia de su existencia más que por referencias documentales. Unos y otros ejemplos se enmarcan dentro del esfuerzo cartográfico español que caracteriza la segunda mitad del siglo XIX.General Reforestation Reports emerge as part of the July 11 1877 Law on reforestation, promotion, and improvement of public forest. These reports were elaborated by the forest districts personnel and sent to the Ministry of Public Works between 1878 and 1884. They include both the objectives and reforestation works proposed by the forestry enginneers as well as information relative to the situation of the Spanish woodlands and, in particular, a basic forest, agronomic and geologic cartography. This cartography is to be framed within the Spanish cartographic effort that characterized the second half of the XIXth century.Este texto se incluye dentro de los trabajos desarrollados en los proyectos de investigación Estudio de los paisajes arquetipo de la agricultura en Castilla y León. Cartografía de los paisajes agrarios de Castilla y León (Referencia VA038A09, Junta de Castilla y León), Las unidades básicas de paisaje agrario en España: identificación, delimitación, caracterización y valorización. La España interior, septentrional y occidental (Referencia CS02009-12225-C05-01, Ministerio de Ciencia e Innovación) y en el Grupo de Investigación de Excelencia GRE156 de la Junta de Castilla y León, además de las exploraciones documentales realizadas a cargo de la XI Beca de Investigación del Museu del Suro de Palafrugell con el trabajo En los márgenes del mundo corchero: la producción, transformación y comercialización del corcho en el noroeste de España

Improving the Generation of Labeled Network Traffic Datasets Through Machine Learning Techniques

The problem of detecting malicious behavior in network traffic has become an extremely difficult challenge for the security community. Consequently, several intelligence-based tools have been proposed to generate models capable of understanding the information traveling through the network and to help in the identification of suspicious connections as soon as possible. However, the lack of high-quality datasets has been one of the main obstacles in the developing of reliable intelligence-based tools. A well-labeled dataset is fundamental not only for the process of automatically learning models but also for testing its performance. Recently, RiskID emerged with the goal of providing to the network security community a collaborative tool for helping the labeling process. Through the use of visual and statistical techniques, RiskID facilitates to the user the generation of labeled datasets from real connections. In this article, we present a machine learning extension for RiskID, to help the user in the malware identification process. A preliminary study shows that as the size of labeled data increases, the use of machine learning models can be a valuable tool during the labeling process of future traffic connections.VI Workshop de Seguridad Informática (WSI).Red de Universidades con Carreras en Informática (RedUNCI

El FSM 2015, un nou impuls per a canviar el món

Abstract not availabl