Diseño y dimensionado de una red de riego localizado para un cultivo de almendros en término municipal de Villena (Alicante)

[ES] En el presente proyecto, se ha abordado el dimensionado y el diseño de una red de riego localizado en una parcela del municipio de Villena (Alicante). Se trata de un terreno en donde, antes, no había infraestructura, pues era terreno de secano. Se han tenido en cuenta, el perfil topográfico del terreno, las características edáficas del suelo y las condiciones climáticas de la zona para llevar a cabo esta red de riego. El cultivo que va a desarrollarse es el almendro, que será producido en superintensivo con un marco de plantación de 4x2, lo que abarca un total de 12.34 ha. Como se ha elegido un sistema de producción superintensivo se esperan rendimientos superiores a la media, por encima de 2500 kg/ha. Tras abordar el diseño agronómico, se procederá al dimensionado de las instalaciones hidráulicas (en su mayoría conducciones) de PVC o PE, según pertenezcan a la red de transporte o a las tuberías de abastecimiento de las subunidades. En última instancia, se tratará el diseño y dimensionado del cabezal y se concretarán los movimientos de tierra necesarios para llevar a cabo esta instalación[EN] In this project, has been addressed the dimensioning and design of an irrigation network placed in a plot where there was any infrastructure, because it was a dry land plot, in order to build up this network it has been taken in consideration the topographic profile, the edaphic traits of the soil and the weather conditions of the zone. The crop to develop is the almond, it will be produced under super intensive conditions, with a plantation frame of 4x2, and it spans a total of 12.34 ha, due to the chosen super intensive production system it is expected a yields higher than 2500 kg/ha. After addressing the agronomic design it will proceed the dimensioning of the hydraulic installations (most of them pipes) made from PVC or PE, it depends if they are part of transport network or supply pipes for the subunits. As a last resort it will be discussed the design and the dimensioning of the irrigation head and earthworks that has to be done in order to build up this network.Alandes Delgado, C. (2020). Diseño y dimensionado de una red de riego localizado para un cultivo de almendros en término municipal de Villena (Alicante). http://hdl.handle.net/10251/153725TFG

A comparison among different sampling-based planning techniques

Consulta en la Biblioteca ETSI Industriales (Riunet)[EN] Nowadays the applications of the robotics are becoming infinite. We can find robots in every aspect of the life, even if we often don’t realize that we are in front of one. We can differentiate some kinds of robots: some of those robots are controlled by an operator, other are set to do some specific job/movement, and others work autonomously with total independence on the operator, interacting by themselves with the environment. In this thesis we are focusing on this last kind of them, and we are going to introduce one of the most widely used libraries in terms of path planning, the OMPL (Open Motion Planning Library) and elaborate a comparison among all the sampling based planning methods included in this library. To do so, we will create an specific problem that will be solve by different methods.[IT] Oggi le applicazioni dei robot stanno diventando infinite. Possiamo trovare i robot in ogni aspetto della vita, anche se spesso non ci rendiamo conto che siamo di fronte ad uno. Possiamo distinguere alcuni tipi di robot: alcuni di questi robot sono controllati da un operatore, altri sono impostati per fare qualche lavoro specifico / movimento, e altri lavorare autonomamente con totale indipendenza sull’operatore, interagendo da soli con l’ambiente. In questa tesina ci stiamo concentrando su questo ultimo tipo di loro, e introduciamo una delle biblioteche più utilizzate in termini di pianificazione del percorso, l’OMPL (Open Motion PLanning Library) ed elaborare un confronto tra tutti i metodi basati in campionatura inclusi in questa libreria. Per fare ciò, creeremo un problema specifico che sarà risolto con metodi diversi.Martinez Alandes, C. (2016). A comparison among different sampling-based planning techniques. http://hdl.handle.net/10251/61716.Archivo delegad

Endothelin-1–Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma

Progression on therapy in non-small cell lung carcinoma (NSCLC) is often evaluated radiographically, however, image-based evaluation of said therapies may not distinguish disease progression due to intrinsic tumor drug resistance or inefficient tumor penetration of the drugs. Here we report that the inhibition of mutated EGFR promotes the secretion of a potent vasoconstrictor, endothelin-1 (EDN1), which continues to increase as the cells become resistant with a mesenchymal phenotype. As EDN1 and its receptor (EDNR) is linked to cancer progression, EDNR-antagonists have been evaluated in several clinical trials with disappointing results. These trials were based on a hypothesis that the EDN1-EDNR axis activates the MAPK-ERK signaling pathway that is vital to the cancer cell survival; the trials were not designed to evaluate the impact of tumor-derived EDN1 in modifying tumor microenvironment or contributing to drug resistance. Ectopic overexpression of EDN1 in cells with mutated EGFR resulted in poor drug delivery and retarded growth in vivo but not in vitro. Intratumoral injection of recombinant EDN significantly reduced blood flow and subsequent gefitinib accumulation in xenografted EGFR-mutant tumors. Furthermore, depletion of EDN1 or the use of endothelin receptor inhibitors bosentan and ambrisentan improved drug penetration into tumors and restored blood flow in tumor-associated vasculature. Correlatively, these results describe a simplistic endogenous yet previously unrealized resistance mechanism inherent to a subset of EGFR-mutant NSCLC to attenuate tyrosine kinase inhibitor delivery to the tumors by limiting drug-carrying blood flow and the drug concentration in tumors. SIGNIFICANCE: EDNR antagonists can be repurposed to improve drug delivery in VEGFA-secreting tumors, which normally respond to TKI treatment by secreting EDN1, promoting vasoconstriction, and limiting blood and drug delivery