Battery energy storage systems for ancillary services in Renewable energy communities

This document presents a study on the use of battery energy storage systems in a proposed renewable energy community in Savona, UNIGE Campus. The study compares the outcomes of cooperative approaches with and without flexibility services to a scenario where users do not cooperate. The study concludes that storage systems of relevant size can create new flexible instruments for the power grid and a powerful tool for citizens, which could make the investment into BESS financially viable. The study also suggests that greater transparency and information on hourly energy sales and purchase prices would facilitate awareness among community members and at the same time stimulate discussion of alternative technologies such as batteries to cover the most expensive nighttime periods for users. Overall, the study highlights the potential of battery systems in renewable energy communities in Italy and provides insights into the importance of coupling flexible services with capacity-building activities and awareness campaigns to promote demand-side-response activities and storage technologies

SARS-CoV-2 Breakthrough Infections: Incidence and Risk Factors in a Large European Multicentric Cohort of Health Workers

The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of more than 60,000 health workers

An integrated approach to decentralized energy systems planning for developing countries

This thesis focuses on the problem of global access to energy for developing countries and provides a thorough analysis of renewable-based mini-grid systems as a solution. In the first section an intensive literature review shows current energy trends and challenges, with a special outlook on Sub-Saharan Africa. The energy forecast situation is assessed by combining data about electric consumptions patterns with an analysis based on the energy indicators for sustainable development issued by International Agencies. A proven methodology for the energy need assessment of rural communities is presented, aiming at obtaining reliable input data for the mini-grid development. This helps in reducing both the financial challenges by mitigating the uncertainties in electricity demand and the technical challenges by contributing to adequately size off-grid power generation systems, with a view to boost toward a common overall objective of mini-grid’s optimization methods and tools. Based on methodology outputs an integrated approach for system design and planning is developed, taking into account techno-economic trade-off and system reliability and flexibility. Design process optimization is carried out through simulation of different combination of generation (PV, Wind, Hydro, multi-source) and storage systems (lead-acid, lithium, vanadium flow, flywheel). Distribution grid constraints have been addressed as well, including last-mile connections and users’ wiring, in order to have an holistic vision in the design phase. Such integrated approach requires to adopt appropriate operation strategies to face real time power quality (voltage and frequency) fluctuations along with an effective capability to meet off-takers demand. Dump loads, device controllers and management options are discussed for both supply-side and demand-side. The thorough analysis looks at economic aspects, therefore different operating strategies are investigated, and business performance has been deeply analysed and discussed. On a view to a global evaluation impact assessment, last part of the thesis focuses on sustainability analysis: beyond economic impact, other direct/indirect effects of mini-grids on environment and target communities are outlined. The tool used for Monitoring and evaluation of mini-grid is the Social Return on Investment ( SROI), by adding a wide set of key indicators to measure monetized effects on education, health, security, environment and economy. The combination of all methodologies and strategies aims at improving the systems design and operation, helping reduce capital expenditures and operating costs, thus allowing for a lower Levelized Cost of Energy over project’s entire lifecycl

How Hybridization of Energy Storage Technologies Can Provide Additional Flexibility and Competitiveness to Microgrids in the Context of Developing Countries

Hybrid microgrids, integrating renewable energy sources and energy storage, are key in extending energy access in the remote areas of developing countries, in a sustainably way and in providing a good quality of service. Their extensive development faces a financing gap, having a high capital expenditure (CAPEX) also due to high storage costs. In the present work, a case study of a Ugandan microgrid was used to compare various battery technologies employed on their own and in a combination with a flywheel, in terms of their durability and the overall levelized cost of energy (LCOE) of the plant. Simulations show how hybrid storage configurations result in a lower LCOE for the current load profile of the microgrid and even more so for two reference residential and industrial load scenarios, suggesting this would remain the best solution even accounting for future socio-economic development. The resulting LCOE for hybrid storage configurations is lower than the average values reported for microgrid projects and represents a promising solution to speed up the development of such electrification initiatives

How hybridization of energy storage technologies can provide additional flexibility and competitiveness to microgrids in the context of developing countries

Hybrid microgrids, integrating renewable energy sources and energy storage, are key in extending energy access in the remote areas of developing countries, in a sustainably way and in providing a good quality of service. Their extensive development faces a financing gap, having a high capital expenditure (CAPEX) also due to high storage costs. In the present work, a case study of a Ugandan microgrid was used to compare various battery technologies employed on their own and in a combination with a flywheel, in terms of their durability and the overall levelized cost of energy (LCOE) of the plant. Simulations show how hybrid storage configurations result in a lower LCOE for the current load profile of the microgrid and even more so for two reference residential and industrial load scenarios, suggesting this would remain the best solution even accounting for future socio-economic development. The resulting LCOE for hybrid storage configurations is lower than the average values reported for microgrid projects and represents a promising solution to speed up the development of such electrification initiatives

Methodology for the energy need assessment to effectively design and deploy mini-grids for rural electrification

In order to successfully deploy a large number of decentralized energy systems in developing countries, it is necessary to standardize effective methodologies and procedures to develop off-grid/mini-grid systems. Considering that the energy need assessment provides inputs and assumptions used in business modelling and mini-grid design, the accuracy of its results directly affects the technical and financial feasibility studies. Thus, the approach for applying a proven methodology for the energy need assessment of rural communities is aimed at obtaining reliable input data for the mini-grid development. This helps in reducing both the financial challenges by mitigating the uncertainties in electricity demand and the technical challenges by contributing to adequately size off-grid power generation systems, with a view to boost toward a common overall objective of mini-grid’s optimization methods and tools. Hence, taking into consideration that target communities differ in terms of needs and context conditions, the proposed paper describes an inclusive methodology that can be adapted case-by-case. It provides an effective applied solution the lack of proven guidelines from project developers or literature, giving priority to data collection methods able to achieve a large sample representative of the market, with high accuracy in estimating the energy consumptions from electricity substitutes

Battery energy storage systems for ancillary services in Renewable energy communities

This document presents a study on the use of battery energy storage systems in a proposed renewable energy community in Savona, UNIGE Campus. The study compares the outcomes of cooperative approaches with and without flexibility services to a scenario where users do not cooperate. The study concludes that storage systems of relevant size can create new flexible instruments for the power grid and a powerful tool for citizens, which could make the investment into BESS financially viable. The study also suggests that greater transparency and information on hourly energy sales and purchase prices would facilitate awareness among community members and at the same time stimulate discussion of alternative technologies such as batteries to cover the most expensive nighttime periods for users. Overall, the study highlights the potential of battery systems in renewable energy communities in Italy and provides insights into the importance of coupling flexible services with capacity-building activities and awareness campaigns to promote demand-side-response activities and storage technologies

The Alternative TrkAIII Splice Variant Targets the Centrosome and Promotes Genetic Instability ▿

The hypoxia-regulated alternative TrkAIII splice variant expressed by human neuroblastomas exhibits oncogenic potential, driven by in-frame exon 6 and 7 alternative splicing, leading to omission of the receptor extracellular immunoglobulin C1 domain and several N-glycosylation sites. Here, we show that the TrkAIII oncogene promotes genetic instability by interacting with and exhibiting catalytic activity at the centrosome. This function depends upon intracellular TrkAIII accumulation and spontaneous interphase-restricted activation, in cytoplasmic tyrosine kinase (tk) domain orientation, predominantly within structures that closely associate with the fully assembled endoplasmic reticulum intermediate compartment and Golgi network. This facilitates TrkAIII tk-mediated binding of γ-tubulin, which is regulated by endogenous protein tyrosine phosphatases and geldanamycin-sensitive interaction with Hsp90, paving the way for TrkAIII recruitment to the centrosome. At the centrosome, TrkAIII differentially phosphorylates several centrosome-associated components, increases centrosome interaction with polo kinase 4, and decreases centrosome interaction with separase, the net results of which are centrosome amplification and increased genetic instability. The data characterize TrkAIII as a novel internal membrane-associated centrosome kinase, unveiling an important alternative mechanism to “classical” cell surface oncogenic receptor tk signaling through which stress-regulated alternative TrkAIII splicing influences the oncogenic process