Fantastic Aspects In Marcel Thiry\u27s Novel Echec du temps

This article establishes how the novel Echec au Temps, often considered within the corpus of Belgian fantastic works, has elements that link it with other genres, such as science fiction. The discovery of several contradictions in the narrative allows us to consider it as indicative of a crisis of representation of reality in the character-narrator rather than an objective testimony. Gustave Dieujeu under the symbolic influence of the father and facing an entrepreneurial inevitable ruin, takes refuge in a neoreality enabling it to confront the return of the repressed feminine pole. This is where the novel ranks well below the fantastic, through the interpretation of fantasy as "fusion of opposites" (Eric Lysøe)

How VASP enhances actin-based motility

The function of vasodilator-stimulated phosphoprotein (VASP) in motility is analyzed using a biomimetic motility assay in which ActA-coated microspheres propel themselves in a medium containing actin, the Arp2/3 complex, and three regulatory proteins in the absence or presence of VASP. Propulsion is linked to cycles of filament barbed end attachment-branching-detachment-growth in which the ActA-activated Arp2/3 complex incorporates at the junctions of branched filaments. VASP increases the velocity of beads. VASP increases branch spacing of filaments in the actin tail, as it does in lamellipodia in living cells. The effect of VASP on branch spacing of Arp2/3-induced branched actin arrays is opposed to the effect of capping proteins. However, VASP does not compete with capping proteins for binding barbed ends of actin filaments. VASP enhances branched actin polymerization only when ActA is immobilized on beads or on Listeria. VASP increases the rate of dissociation of the branch junction from immobilized ActA, which is the rate-limiting step in the catalytic cycle of site-directed filament branching

An unusual culprit lesion in acute coronary syndrome: In stent-restenosis of a subclavian artery stent

peer reviewedA 73-year old man with past medical history of coronary artery bypass grafting in 2012 and subclavian artery stenting in 2021 was scheduled for an ophthalmologic minor surgery requiring conscious sedation. During the surgery, he developed hemodynamic instability and shortness of breath requiring the conversion to general anesthesia with mechanical ventilation. An electrocardiogram was immediately realized revealing deep negative T waves in all the precordial leads. Elevated troponin level confirmed the diagnosis of non-ST elevation myocardial infarction. Urgent coronary artery angiography revealed a known left coronary system with a chronic Left Anterior Descending (LAD) artery occlusion, a chronic occlusion of the distal circumflex artery and a severe stenosis of left main stem. The right coronary artery presented a significant and calcified stenosis on its mid part. The two venous grafts on the obtuse marginal and the posterolateral artery were both patent. The left subclavian artery could not be crossed to selectively film the left internal mammary artery and an angiogram revealed a tight stenosis in the previous stented segment, limiting the blood flow in the left internal mammary artery. Careful review of the in-stent restenosis suggested neointimal hyperplasia and stent fracture, as detected by stentboost imaging

The interaction between lipid derivatives of colchicine and tubulin: Consequences of the interaction of the alkaloid with lipid membranes

AbstractColchicine is a potent antimitotic poison which is well known to prevent microtubule assembly by binding tubulin very tightly. Colchicine also possesses anti-inflammatory properties which are not well understood yet. Here we show that colchicine tightly interacts with lipid layers. The physical and biological properties of three different lipid derivatives of colchicine are investigated parallel to those of membrane lipids in the presence of colchicine. Upon insertion in the fatty alkyl chains, colchicine rigidifies the lipid monolayers in a fluid phase and fluidifies rigid monolayers. Similarly X-ray diffraction data show that lecithin–water phases are destabilized by colchicine. In addition, an unexpectedly drastic enhancement of the photoisomerization rate of colchicine into lumicolchicine in the lipid environment is observed and further supports insertion of the alkaloid in membranes. Finally the interaction of colchicine with lipids makes the drug inaccessible to tubulin. The possible in vivo significance of these results is discussed

Bioresorbable Magnesium-Based Stent: Real-World Clinical Experience and Feasibility of Follow-Up by Coronary Computed Tomography: A New Window to Look at New Scaffolds

peer reviewed(1) Background: The diagnostic accuracy of coronary computed tomography angiography (CCTA) for coronary artery disease (CAD) has greatly improved so CCTA represents a transition in the care of patients suffering from CAD. Magnesium-based bioresorbable stents (Mg-BRS) secure acute percutaneous coronary intervention (PCI) results without leaving, in the long term, a metallic caging effect. The purpose of this real-world study was to assess clinical and CCTA medium- and long-term follow-up of all our patients with implanted Mg-BRS. (2) Methods: The patency of 52 Mg-BRS implanted in 44 patients with de novo lesions (24 of which had acute coronary syndrome (ACS)) was evaluated by CCTA and compared to quantitative coronary angiography (QCA) post-implantation. (3) Results: ten events including four deaths occurred during a median follow-up of 48 months. CCTA was interpretable and in-stent measurements were successful at follow-up without being hindered by the stent strut’s “blooming effect”. Minimal in-stent diameters on CCTA were found to be 1.03 ± 0.60 mm smaller than the expected diameter after post-dilation on implantation (p < 0.05), a difference not found in comparing CCTA and QCA. (4) Conclusions: CCTA follow-up of implanted Mg-BRS is fully interpretable and we confirm the long-term Mg-BRS safety profile

Successful Leptogenesis in SO(10) Unification with a Left-Right Symmetric Seesaw Mechanism

We study thermal leptogenesis in a broad class of supersymmetric SO(10) models with a left-right symmetric seesaw mechanism, taking into account flavour effects and the contribution of the next-to-lightest right-handed neutrino supermultiplet. Assuming M_D = M_u and a normal hierarchy of light neutrino masses, we show that four out of the eight right-handed neutrino mass spectra reconstructed from low-energy neutrino data can lead to successful leptogenesis with a reheating temperature in the (10^9 - 10^10) GeV range. In the remaining four solutions, leptogenesis is dominated by N_2 decays, as in the type I seesaw case. We find that some of these spectra can generate the observed baryon asymmetry for reheating temperatures above 10^10 GeV, in contrast to the type I case. Together with flavour effects, an accurate description of charged fermion masses turns out to be a crucial ingredient in the analysis.Comment: 32 pages, 23 figures. v2: 2 comments [below Eq. (53) and at the end of the conclusions] and 1 reference added, typos corrected. Version to be published in Nucl. Phys.

Acute tubulointerstitial nephritis complicating Legionnaires' disease: a case report

<p>Abstract</p> <p>Introduction</p> <p>Legionnaires' disease is recognized as a multi-systemic illness. Afflicted patients may have pulmonary, renal, gastrointestinal tract and central nervous system complications. However, renal insufficiency is uncommon. The spectrum of renal involvement may range from a mild and transient elevation of serum creatinine levels to anuric renal failure requiring dialysis and may be linked to several causes. In our present case report, we would like to draw attention to the importance of the pathological documentation of acute renal failure by reporting a case of a patient with acute tubulointerstitial nephritis complicating Legionnaires' disease.</p> <p>Case presentation</p> <p>A 55-year-old Caucasian man was admitted to our hospital for community-acquired pneumonia complicated by acute renal failure. <it>Legionella pneumophila </it>serogroup type 1 was diagnosed. Although the patient's respiratory illness responded to intravenous erythromycin and ofloxacin therapy, his renal failure worsened, he became anuric, and hemodialysis was started. A renal biopsy was performed, which revealed severe tubulointerstitial nephritis. After initiation of steroid therapy, his renal function improved dramatically.</p> <p>Conclusions</p> <p>This case highlights the importance of kidney biopsies in cases where acute renal failure is a complicating factor in Legionnaires' disease. If the presence of acute tubulointerstitial nephritis can be confirmed, it will likely respond favorably to steroidal treatment and thus irreversible renal damage and chronic renal failure will be avoided.</p

Chagas Disease, France

Chagas Disease, Franc