750 research outputs found

    Outsourcing and externalisation: current practice in UK libraries, museums and archives

    Get PDF
    A study, funded by Resource: The Council for Museums, Archives and Libraries, was undertaken in 2000-2001 to give an up-to-date view of the current experience of outsourcing and externalisation in libraries, museums and archives. Case studies of purchasers recognised as pioneers in the field, and of providers, were undertaken, and results validated by two focus groups. Outsourcing, particularly under the impetus of Best Value, was found to be relatively widespread and sophisticated in the public library and special library sectors. Thinking and practice in academic libraries lag behind. Museums and archives show some implementation, particularly under the influence of Best Value

    Outsourcing and externalisation: current practice in UK libraries, museums and archives

    Get PDF
    A study, funded by Resource: The Council for Museums, Archives and Libraries, was undertaken in 2000-2001 to give an up-to-date view of the current experience of outsourcing and externalisation in libraries, museums and archives. Case studies of purchasers recognised as pioneers in the field, and of providers, were undertaken, and results validated by two focus groups. Outsourcing, particularly under the impetus of Best Value, was found to be relatively widespread and sophisticated in the public library and special library sectors. Thinking and practice in academic libraries lag behind. Museums and archives show some implementation, particularly under the influence of Best Value

    Characteristics of lesser prairie-chicken (Tympanuchus pallidicinctus) long-distance movements across their distribution

    Get PDF
    Citation: Earl, J. E., Fuhlendorf, S. D., Haukos, D., Tanner, A. M., Elmore, D., & Carleton, S. A. (2016). Characteristics of lesser prairie-chicken (Tympanuchus pallidicinctus) long-distance movements across their distribution. Ecosphere, 7(8). doi:10.1002/(ISSN)2150-8925Long-distance movements are important adaptive behaviors that contribute to population, community, and ecosystem connectivity. However, researchers have a poor understanding of the characteristics of long-distance movements for most species. Here, we examined long-distance movements for the lesser prairie-chicken (Tympanuchus pallidicinctus), a species of conservation concern. We addressed the following questions: (1) At what distances could populations be connected? (2) What are the characteristics and probability of dispersal movements? (3) Do lesser prairie-chickens display exploratory and round-trip movements? (4) Do the characteristics of long-distance movements vary by site? Movements were examined from populations using satellite GPS transmitters across the entire distribution of the species in New Mexico, Oklahoma, Kansas, and Colorado. Dispersal movements were recorded up to 71 km net displacement, much farther than hitherto recorded. These distances suggest that there may be greater potential connectivity among populations than previously thought. Dispersal movements were displayed primarily by females and had a northerly directional bias. Dispersal probabilities ranged from 0.08 to 0.43 movements per year for both sexes combined, although these movements averaged only 16 km net displacement. Lesser prairie-chickens displayed both exploratory foray loops and round-trip movements. Half of round-trip movements appeared seasonal, suggesting a partial migration in some populations. None of the long-distance movements varied by study site. Data presented here will be important in parameterizing models assessing population viability and informing conservation planning, although further work is needed to identify landscape features that may reduce connectivity among populations. © 2016 Earl et al

    A Tablet-based Virtual Environment for Neurosurgery Training

    Get PDF
    Published in Presence: Teleoperators and Virtual Environments, Spring 2015No. 2, Pages 155-162 Posted Online October 15, 2015. doi:10.1162/PRES_a_00224The requirement for training surgical procedures without exposing the patient to additional risk is well accepted and is part of a national drive in the UK and internationally. Computer-based simulations are important in this context, including neurosurgical resident training. The objective of this study is to evaluate the effectiveness of a custom built virtual environment in assisting training of a ventriculostomy procedure. The training tool (called VCath) has been developed as an app for a tablet platform to provide easy access and availability to trainees. The study was conducted at the first boot camp organized for all year one trainees in neurosurgery in the UK. The attendees were randomly distributed between the VCath training group and the Control group. Efficacy of performing ventriculostomy for both groups was assessed at the beginning and end of the study using a simulated insertion task. Statistically significant changes in performance of selecting the burr hole entry point, the trajectory length and duration metrics for the VCath group, together with a good indicator of improved normalized jerk (representing the speed and smoothness of arm motion), all suggest that there has been a higher level cognitive benefit to using VCath. The app is successful as it is focused on the cognitive task of ventriculostomy, encouraging the trainee to rehearse the entry point and use anatomical landmarks to create a trajectory to the target. In straight-line trajectory procedures such as ventriculostomy, cognitive task based education is a useful adjunct to traditional methods and may reduce the learning curve and ultimately improve patient safety

    Updating the TSP Quality Plan Using Monte Carlo Simulation

    Get PDF
    Humphrey tries to answer one of software management’s biggest questions, showing how one naval organization with large system projects, over a 15-year period, used the TSP to help them with planning and tracking, meeting schedules, and understanding knowledge work. by Watts S. Humphrey An Interview with Watts S. Humphrey Who else can boast more than a half-century in the software industry? Humphrey sits down with CrossTalk to reflect on some of his most illuminating experiences in the software industry and discusses the past, present, and future of his innovations—including the TSP

    Quantum Algorithm Implementations for Beginners

    Full text link
    As quantum computers become available to the general public, the need has arisen to train a cohort of quantum programmers, many of whom have been developing classical computer programs for most of their careers. While currently available quantum computers have less than 100 qubits, quantum computing hardware is widely expected to grow in terms of qubit count, quality, and connectivity. This review aims to explain the principles of quantum programming, which are quite different from classical programming, with straightforward algebra that makes understanding of the underlying fascinating quantum mechanical principles optional. We give an introduction to quantum computing algorithms and their implementation on real quantum hardware. We survey 20 different quantum algorithms, attempting to describe each in a succinct and self-contained fashion. We show how these algorithms can be implemented on IBM's quantum computer, and in each case, we discuss the results of the implementation with respect to differences between the simulator and the actual hardware runs. This article introduces computer scientists, physicists, and engineers to quantum algorithms and provides a blueprint for their implementations

    Developmental arrest of T cells in RpL22-deficient mice is dependent upon multiple p53 effectors

    Get PDF
    available in PMC 2012 July 15alpha beta and gamma delta lineage T cells are thought to arise from a common CD4–CD8– progenitor in the thymus. However, the molecular pathways controlling fate selection and maturation of these two lineages remain poorly understood. We demonstrated recently that a ubiquitously expressed ribosomal protein, Rpl22, is selectively required for the development of alpha beta lineage T cells. Germline ablation of Rpl22 impairs development of alpha beta lineage, but not gamma delta lineage, T cells through activation of a p53-dependent checkpoint. In this study, we investigate the downstream effectors used by p53 to impair T cell development. We found that many p53 targets were induced in Rpl22−/− thymocytes, including miR-34a, PUMA, p21waf, Bax, and Noxa. Notably, the proapoptotic factor Bim, while not a direct p53 target, was also strongly induced in Rpl22−/− T cells. Gain-of-function analysis indicated that overexpression of miR-34a caused a developmental arrest reminiscent of that induced by p53 in Rpl22-deficient T cells; however, only a few p53 targets alleviated developmental arrest when individually ablated by gene targeting or knockdown. Co-elimination of PUMA and Bim resulted in a nearly complete restoration of development of Rpl22−/− thymocytes, indicating that p53-mediated arrest is enforced principally through effects on cell survival. Surprisingly, co-elimination of the primary p53 regulators of cell cycle arrest (p21waf) and apoptosis (PUMA) actually abrogated the partial rescue caused by loss of PUMA alone, suggesting that the G1 checkpoint protein p21[superscript waf] facilitates thymocyte development in some contexts.National Institutes of Health (U.S.) ( (NIH) Grant R01AI073920)National Institutes of Health (U.S.) (NIH Core Grant P01CA06927)National Institutes of Health (U.S.) ( (NIH) Grant R21CA141194)National Institutes of Health (U.S.) ( NIH Center Grant P30-DK-50306)Pennsylvania (appropriation)Fox Chase Cancer Center (NIH Postdoctoral Training Grant T32 CA00903534)Fox Chase Cancer Center (NIH Postdoctoral Training Grant F32 AI089077-01A1
    corecore