Modeling the values of private sector agents in multi-echelon humanitarian supply chains

© 2018 Elsevier B.V. Humanitarian organizations (HOs) increasingly look to engage private sector supply chains in achieving outcomes. The right engagement approach may require knowledge of agents' preferences across multi-echelon supply chains to align private sector value creation with humanitarian outcomes. We propose a multi-attribute value analysis (MAVA) framework to elucidate such preferences. We formalize this approach and apply it in collaboration with a HO pilot aiming to facilitate better private sector availability of malaria rapid diagnostic tests in Uganda. We demonstrate how HOs could use criteria weights and value functions from MAVA for project evaluation; in the process, we reveal business model insights for importers, distributors, and retailers in the pilot. We also show how MAVA facilitates the impact assessment of hypothetical options (i.e., combinations of products, services, and subsidies) to guide HO resource deployment. This paper offers the first attempt, to our knowledge, to develop quantitative measures for economic and non-economic objectives involving all agents in a multi-echelon supply chain, either humanitarian or commercial. We hope that this initial step stimulates further research to validate results and develop the framework proposed

Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases

Background: Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins can identify genetic variants that lead to relative protein abundance. Methods: We conducted a meta-analysis on genome-wide association studies of autosomal chromosomes in 22,997 individuals of primarily European ancestry across 12 cohorts to identify protein quantitative trait loci (pQTL) for 92 cardiometabolic associated plasma proteins. Results: We identified 503 (337 cis and 166 trans) conditionally independent pQTLs, including several novel variants not reported in the literature. We conducted a sex-stratified analysis and found that 118 (23.5%) of pQTLs demonstrated heterogeneity between sexes. The direction of effect was preserved but there were differences in effect size and significance. Additionally, we annotate trans-pQTLs with nearest genes and report plausible biological relationships. Using Mendelian randomization, we identified causal associations for 18 proteins across 19 phenotypes, of which 10 have additional genetic colocalization evidence. We highlight proteins associated with a constellation of cardiometabolic traits including angiopoietin-related protein 7 (ANGPTL7) and Semaphorin 3F (SEMA3F). Conclusion: Through large-scale analysis of protein quantitative trait loci, we provide a comprehensive overview of common variants associated with plasma proteins. We highlight possible biological relationships which may serve as a basis for further investigation into possible causal roles in cardiometabolic diseases

Evaluating incentives and priorities of private sector supply chain agents to scale up rapid diagnostic tests for malaria in Uganda

Thesis: S.M. in Technology and Policy, Massachusetts Institute of Technology, Engineering Systems Division, 2015.Cataloged from PDF version of thesis.Includes bibliographical references (pages 162-168).Diagnosis of malaria is important in order to ensure early and effective treatment, to facilitate public health surveillance, and to prevent drug resistance. Rapid diagnostic tests (RDTs) are an important tool in resource-constrained settings, as they do not rely on costly lab equipment and specially trained personnel. In Uganda's private sector clinics and drug shops, which is where the majority of patients first seek care, diagnosis of malaria is often presumptive and patients receive neither RDT nor microscopy. Several studies have focused on the patient perspective (e.g. willingness to pay and willingness to be tested) but much less is understood about the supplier perspective (e.g. willingness to stock). This study aimed to understand the preferences and priorities of agents across the malaria RDT supply chain in Uganda on stocking the devices using multi-criteria decision analysis. This methodology was adapted to be relevant and understandable for agents in Uganda so that it was possible to analyze business decisions incorporating a multiplicity of attributes such as selling price, purchase cost, sales volume, complexity of regulations, waste management, and training available. Data surveys and semistructured interviews were collected from 28 private sector retailers (i.e., shopkeepers, pharmacists, clinic managers), two first line buyers, and three distributors. Analysis of the data resulted in the construction of value functions for all agents, the relative weights (therefore the tradeoffs) among decision criteria, and the calculation of an overall value for the decision about whether or not to stock RDTs for the different supply chain agents. Results indicate that the best option for one level of the supply chain is not necessarily the best for another. A discussion offers insights on how to align value across the supply chain, which is important for facilitating public health interventions.by Corinne M. Carland.S.M. in Technology and Polic

Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases.

BACKGROUND: Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins can identify genetic variants that lead to relative protein abundance. METHODS: We conducted a meta-analysis on genome-wide association studies of autosomal chromosomes in 22,997 individuals of primarily European ancestry across 12 cohorts to identify protein quantitative trait loci (pQTL) for 92 cardiometabolic associated plasma proteins. RESULTS: We identified 503 (337 cis and 166 trans) conditionally independent pQTLs, including several novel variants not reported in the literature. We conducted a sex-stratified analysis and found that 118 (23.5%) of pQTLs demonstrated heterogeneity between sexes. The direction of effect was preserved but there were differences in effect size and significance. Additionally, we annotate trans-pQTLs with nearest genes and report plausible biological relationships. Using Mendelian randomization, we identified causal associations for 18 proteins across 19 phenotypes, of which 10 have additional genetic colocalization evidence. We highlight proteins associated with a constellation of cardiometabolic traits including angiopoietin-related protein 7 (ANGPTL7) and Semaphorin 3F (SEMA3F). CONCLUSION: Through large-scale analysis of protein quantitative trait loci, we provide a comprehensive overview of common variants associated with plasma proteins. We highlight possible biological relationships which may serve as a basis for further investigation into possible causal roles in cardiometabolic diseases

Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases

Background: Human plasma contains a wide variety of circulating proteins. These proteins can be important clinical biomarkers in disease and also possible drug targets. Large scale genomics studies of circulating proteins can identify genetic variants that lead to relative protein abundance. Methods: We conducted a meta-analysis on genome-wide association studies of autosomal chromosomes in 22,997 individuals of primarily European ancestry across 12 cohorts to identify protein quantitative trait loci (pQTL) for 92 cardiometabolic associated plasma proteins. Results: We identified 503 (337 cis and 166 trans) conditionally independent pQTLs, including several novel variants not reported in the literature. We conducted a sex-stratified analysis and found that 118 (23.5%) of pQTLs demonstrated heterogeneity between sexes. The direction of effect was preserved but there were differences in effect size and significance. Additionally, we annotate trans-pQTLs with nearest genes and report plausible biological relationships. Using Mendelian randomization, we identified causal associations for 18 proteins across 19 phenotypes, of which 10 have additional genetic colocalization evidence. We highlight proteins associated with a constellation of cardiometabolic traits including angiopoietin-related protein 7 (ANGPTL7) and Semaphorin 3F (SEMA3F). Conclusion: Through large-scale analysis of protein quantitative trait loci, we provide a comprehensive overview of common variants associated with plasma proteins. We highlight possible biological relationships which may serve as a basis for further investigation into possible causal roles in cardiometabolic diseases