Chapter Massimo Quaini e il CISGE

Among the geographical associations the Italian Centre for Historical and Geographical Studies (CISGE) was the one with which Massimo Quaini maintained a stronger relationship. In addition to the sharing of the study fields, Quaini was also linked to CISGE by the close and inseparable link between geography and history, the combination of concrete research and theoretical reflection, the plurality of approaches, the continuous dialectic and the marked interdisciplinarity. Elements that have always characterized the Centre since its foundation, becoming concrete in meetings, seminars, conferences, research groups, national and international projects and in numerous publications. Through a careful analysis of Quaini’s writings contained in the proceedings, the collections of essays and the journal Geostorie (which since 2000 replaced the Notiziario del CISGE) – a long and uninterrupted series from 1992 to 2017 – the contribution aims at highlighting the original, critical and stimulating contribution offered by Massimo to the four fundamental study streams of CISGE: historical geography, history of cartography, history of geographical thought, history of travels and of explorations

Sex Differences in Outcomes After Percutaneous Coronary Intervention or Coronary Artery Bypass Graft for Left Main Disease: From the DELTA Registries

Background Controversy exists over whether sex has significant interaction with revascularization strategy for unprotected left main coronary artery disease. Higher mortality has been reported among women treated with percutaneous coronary intervention compared with coronary artery bypass grafting. Methods and Results The DELTA (Drug-Eluting Stents for Left Main Coronary Artery Disease) and DELTA-2 registries are international, multicentric registries evaluating the outcomes of subjects undergoing coronary revascularization for unprotected left main coronary artery disease. The primary outcome was a composite of death, myocardial infarction, or cerebrovascular accidents. The population consisted of 6253 patients, including 1689 (27%) women. Women were older and more likely to have diabetes and chronic kidney disease than men (P<0.05). At a median follow-up of 29 months (interquartile range 12-49), a significant interaction between sex and revascularization strategy was observed for the primary end point (pint=0.012) and all-cause death (pint=0.037). Among women, compared with percutaneous coronary intervention, coronary artery bypass grafting was associated with lower risk of the primary end point (event rate 9.5% versus 15.3%; adjusted hazard ratio [AHR], 0.53; 95% CI, 0.35-0.79, P<0.001) and all-cause death (event rate 5.6% versus 11.7% AHR, 0.50; 95% CI, 0.30-0.82) and no significant differences were observed in men. Conclusions In women undergoing coronary revascularization for unprotected left main coronary artery disease, coronary artery bypass grafting was associated with lower risk of death, myocardial infarction, or cerebrovascular accidents whereas no significant differences between coronary artery bypass grafting and percutaneous coronary intervention were observed in men. Further dedicated studies are needed to determine the optimal revascularization strategy in women with unprotected left main coronary artery disease. Keywords: cardiovascular disease in women; coronary revascularization; unprotected left main coronary artery disease

Comparative external validation of the PRECISE-DAPT and PARIS risk scores in 4424 acute coronary syndrome patients treated with prasugrel or ticagrelor

Background: The PRECISE-DAPT and PARIS risk scores (RSs) were recently developed to help clinicians at individualizing the optimal dual antiplatelet therapy duration (DAPT) after percutaneous coronary intervention (PCI). Nevertheless, external validation of these RSs it has not yet been performed in ACS (acute coronary syndrome) patients treated with prasugrel or ticagrelor in a real- world scenario. Methods: 4424 ACS patients who underwent PCI and survived to hospital discharge, from January 2012 to December 2016 at 12 European centers, were included. PRECISE-DAPT and PARIS bleeding RS, as well as PARIS ischemic RS, were computed, and their performance at predicting major bleeding (MB; BARC type 3 or 5) and ischemic events (MI and stent thrombosis) during follow up was compared. Results: After a median follow-up of 14 (interquartile range 12–20.9) months, 83 (1.88%) patients developed MB and 133 (3.0%) suffered an ischemic episode. PRECISE-DAPT performed better than PARIS bleeding RS (c-statistic = 0.653 vs. 0.593; p =.01 for comparison) in predicting MB. The RSs performance for MB prediction remained consistent in STEMI patients (c-statistic = 0.632 vs 0.575) or in those treated with prasugrel (c-statistic = 0.623 vs 0.586). PARIS ischemic RS exhibited superior discrimination in predicting ischemic complications compared to PRECISE-DAPT (c-statistic = 0.604 vs 0.568 p =.05 for comparison). Conclusion: Our data provide support to the use of PRECISE-DAPT in MB risk stratification for patients receiving DAPT in form of aspirin and prasugrel or ticagrelor whereas the PARIS ischemic RS has potential to complement the risk prediction with respect to ischemic events

Prognostic impact of acute pulmonary triggers in patients with Takotsubo syndrome : new insights from the International Takotsubo Registry

© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characteristics and outcomes. Of the 1670 included patients with TTS, 123 (7%) were identified with an acute pulmonary trigger, and 194 (12%) had a known history of chronic lung disease. The incidence of cardiogenic shock was highest in patients with an acute pulmonary trigger compared with those with chronic lung disease or without lung disease (17% vs. 10% vs. 9%, P = 0.017). In-hospital mortality was also higher in patients with an acute pulmonary trigger than in the other two groups, although not significantly (5.7% vs. 1.5% vs. 4.2%, P = 0.13). Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interval 1.33-3.38; P = 0.002). Conclusions: The present study demonstrates that TTS is related to acute pulmonary triggers in 7% of all TTS patients, which accounts for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome.C. T. has been supported by the H.H. Sheikh Khalifa binHamad Al-Thani Research Programme and the Swiss HeartFoundation. The InterTAK Registry is supported by the BissDavies Charitable Trust. L. S. M. has been supported by EUHORIZON 2020(SILICOFCM ID777204)info:eu-repo/semantics/publishedVersio

Introduzione alla STD3. Cartografi in movimento: biografie, scuole, reti

In un Congresso Geografico Italiano espressamente dedicato alle «Geografie in movimento» come studiose che si riconoscono per teorie, metodi e strumenti nel gruppo riunito attorno al Centro Italiano per gli Studi Storico-Geografici, e volendo dare voce al polifonico coro delle ricercatrici e dei ricercatori che, con varie declinazioni, si occupano di cartografia e la utilizzano come fonte, insieme ad altre di diversa natura, è sembrato opportuno e pertinente proporre una sessione fondata sul concetto di movimento delle persone e delle idee, dei cartografi e delle cartografie. È nato così, sulla scorta di un costante dibattito interno al gruppo e di un confronto con altre posizioni dentro e fuori dalla disciplina geografica, questo momento di incontro dal titolo Cartografi in movimento: biografie, scuole, reti. Constatiamo con grande soddisfazione che la nostra idea ha raccolto un buon numero di adesioni e che il ventaglio di chiavi di lettura presentate dalle colleghe e dai colleghi intervenuti ha approfondito e ampliato in maniera diacronicamente e tematicamente armonica il quadro sinteticamente delineato nella call e intrecciato molti degli spunti proposti, insieme ad altri originali2. Così come non possiamo esimerci dal sottolineare l’apprezzabile rigore metodologico dei singoli contributi qui raccolti che, attraverso un approccio diacronico e filologico alle fonti, fanno emergere la centralità della ricerca di archivio e la necessità di contestualizzare ogni corpus documentario preso in analisi

Presentazione della Sessione STD3. Cartografi in movimento: biografie, scuole, reti

Proposta della sessione tematica STD3. Cartografi in movimento: biografie, scuole, ret