Subject preferences in the fifth grade

Thesis (Ed.M.)--Boston University, 1948. This item was digitized by the Internet Archive

Healthy Seniors: Supporting Chronic Condition Management Through Educational and Motivational Materials.

Within the United States, the older adult population is rising and facing a growing number of chronic conditions (Mirza et al., 2020). Chronic conditions are associated with an increase in hospitalizations, functional decline, and healthcare spending. Largely, chronic conditions are managed under primary care physicians and treatment is not put into place until an exacerbation and hospitalization occurs (Mirza et al., 2020). Thus, a cruel cycle is created in which an individual undergoes functional decline, worsening of the condition, and decreasing quality of life and well-being. The older adult population wishes to age in place and manage their health; however, are not provided materials and resources to do so until an exacerbation occurs (Elliot, 2019). Although online resources exist through patient portals, older adults lack the confidence to access and apply them (Theisen et al., 2021). Purpose: To develop evidence-based educational materials for older adults to use to maintain independence and improve quality of life. Additionally, work to incorporate motivational factors for residents to self-manage their help.https://soar.usa.edu/otdcapstonesfall2023/1008/thumbnail.jp

Policy gaps in addressing social determinants of health for Australians with a disability

Compared to non-disabled people, Australians with a disability have poorer health and experience greater levels of socio-economic disadvantage e.g. unemployment, housing insecurity, and social exclusion. Reducing these inequities could significantly improve the health of Australians with a disability. However, in Australia there is a lack of knowledge on how to target health and social policies which address the social determinants of health for people with a disability in order to reduce social and economic disadvantage

Bridging the Gap from New Graduate to Practicing Occupational Therapist: An Educational Resource in Orthopedics

OT is pivotal in the rehabilitation and recovery of individuals with orthopedic conditions (Nelson, 2010). However, as a new graduate occupational therapist, there is limited support as they make the transition to clinical practice (Turpin et al., 2021). New graduates receive support through professional mentorship and peer support but are often focused on the safe practice of basic skills rather than on best practices (Opoku et al., 2021). New graduates would feel more confident in clinical judgment and decision-making with additional support from mentors and accessible up-to-date resources (Adam et al., 2013). Purpose: Develop an accessible resource for new occupational therapists entering the orthopedic setting.https://soar.usa.edu/otdcapstonesfall2023/1009/thumbnail.jp

Addressing ALS Caregiver Needs: An Occupation-Based Caregiver Education Program

This program adds a new component to the Les Turner ALS Foundation’s already established online educational programs. The foundation had a program for people living with ALS but did not have a program for caregivers prior to this project. A needs assessment was completed to determine caregiver needs and materials for caregivers were developed based on the needs found. The materials developed were implemented with ten caregivers to determine effectiveness and outcomes before launching the program to the general public.https://soar.usa.edu/otdcapstones-spring2022/1004/thumbnail.jp

A case control study reveals that polyomaviruria is significantly associated with interstitial cystitis and vesical ulceration

Objectives: To investigate whether polyomaviruses contribute to interstitial cystitis pathogenesis. Subjects and Methods: A prospective study was performed with 50 interstitial cystitis cases compared with 50 age-matched, disease-free controls for the frequency of polyomaviruria. Associations between polyomaviruria and disease characteristics were analysed in cases. Polyomavirus in urine and bladder tissue was detected with species (JC virus vs. BK virus) specific, real-time PCR. Results: Case patients were reflective of interstitial cystitis epidemiology with age range from 26–88 years (median 58) and female predominance (41/50 F). There was a significant increase in the frequency of polyomavirus shedding between cases and controls (p<0.02). Polyomavirus shedding, in particular BK viruria, was associated with vesical ulceration, a marker of disease severity, among interstitial cystitis cases after adjustment for age and sex (OR 6.8, 95% CI 1.89–24.4). There was a significant association among cases between the presence of BK viruria and response to intravesical Clorpactin therapy (OR 4.50, 95% CI 1.17–17.4). Conclusion: The presence of polyomaviruria was found to be associated with the ulcerative form of interstitial cystitis. Clorpactin, which has anti-DNA virus activity, was more likely to improve symptoms in the presence of BK viruria. These data from this pilot study suggest associations between polyomaviruria and interstitial cystitis warranting further investigation

Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Intrachromosomal amplification of chromosome 21 is a heterogeneous chromosomal rearrangement occurring in 2% of childhood precursor B-cell acute lymphoblastic leukemia. There are no cell lines with iAMP21 and these abnormalities are too complex to faithfully engineer in animal models. As a resource for future functional and pre-clinical studies, we have created xenografts from intrachromosomal amplification of chromosome 21 leukemia patient blasts and characterised them by in-vivo and ex-vivo luminescent imaging, FLOW immunophenotyping, and histological and ultrastructural analysis of bone marrow and the central nervous system. Investigation of up to three generations of xenografts revealed phenotypic evolution, branching genomic architecture and, compared with other B-cell acute lymphoblastic leukemia genetic subtypes, greater clonal diversity of leukemia initiating cells. In support of intrachromosomal amplification of chromosome 21 as a primary genetic abnormality, it was always retained through generations of xenografts, although we also observed the first example of structural evolution of this rearrangement. Clonal segregation in xenografts revealed convergent evolution of different secondary genomic abnormalities implicating several known tumour suppressor genes and a region, containing the B-cell adaptor, PIK3AP1, and nuclear receptor co-repressor, LCOR, in the progression of B-ALL. Tracking of mutations in patients and derived xenografts provided evidence for co-operation between abnormalities activating the RAS pathway in B-ALL and for their aggressive clonal expansion in the xeno-environment. Bi-allelic loss of the CDKN2A/B locus was recurrently maintained or emergent in xenografts and also strongly selected as RNA sequencing demonstrated a complete absence of reads for genes associated with the deletions

Reading problems of the bottom third: grades one through six

Thesis (Ed.M.)--Boston Universit