Spatiotemporal patterns and agro-ecological risk factors for cutaneous and renal glomerular vasculopathy (Alabama Rot) in dogs in the UK

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased or decreased risk of being diagnosed with CRGV, and to report on age and sex distributions of CRGV cases occurring in the UK. Multivariable logistic regression was used to compare 101 dogs diagnosed with CRGV between November 2012 and May 2017 with a denominator population of 446,453 dogs from the VetCompass database. Two Kennel Club breed groups—hounds (odds ratio (OR) 10.68) and gun dogs (OR 9.69)—had the highest risk of being diagnosed with CRGV compared with terriers, while toy dogs were absent from among CRGV cases. Females were more likely to be diagnosed with CRGV (OR 1.51) as were neutered dogs (OR 3.36). As well as helping veterinarians develop an index of suspicion for the disease, better understanding of the signalment risk factors may assist in the development of causal models for CRGV and help identify the aetiology of the disease

Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased or decreased risk of being diagnosed with CRGV, and to report on age and sex distributions of CRGV cases occurring in the UK. Multivariable logistic regression was used to compare 101 dogs diagnosed with CRGV between November 2012 and May 2017 with a denominator population of 446,453 dogs from the VetCompass database. Two Kennel Club breed groups—hounds (odds ratio (OR) 10.68) and gun dogs (OR 9.69)—had the highest risk of being diagnosed with CRGV compared with terriers, while toy dogs were absent from among CRGV cases. Females were more likely to be diagnosed with CRGV (OR 1.51) as were neutered dogs (OR 3.36). As well as helping veterinarians develop an index of suspicion for the disease, better understanding of the signalment risk factors may assist in the development of causal models for CRGV and help identify the aetiology of the disease

A systematic assessment of the association between frequently-prescribed medicines and the risk of common cancers : a series of nested case-control studies

Funding: This work was supported by Cancer Research UK (reference C37316/A25535). Acknowledgements: We wish to thank PCCIUR, University of Aberdeen, especially Artur Wozniak, for extracting the data and performing case-control matching.Peer reviewedPublisher PD

The effect of medications associated with drug-induced pancreatitis on pancreatic cancer risk : a nested case-control study of routine Scottish data

Funding: This work was supported by Cancer Research UK (reference C37316/A25535). Acknowledgements: We wish to thank PCCIUR, University of Aberdeen, especially Artur Wozniak, for extracting the data and performing case-control matching.Peer reviewedPublisher PD

Fluktuacije faze supravodljivog uređenja u osnovnom stanju kao preduvjet jakih kritičnih fluktuacija u visokotemperaturnim supravodičima

We analyse the reversible magnetisation and heat capacity of YBa2Cu3O7−δ in the “vortex liquid” state and find that both properties are reasonably well described by the 3D XY critical-fluctuation model. The free-energy density in the “vortex liquid” state has a particularly simple form over a wide range of fields (H) and temperatures (T). This leads us to a picture in which the presence of critical fluctuations in high-Tc superconductors is directly linked to the remarkably small number of overlapping Cooper pairs at T=0 and H=0 rather than low dimensionality or high temperatures.Analiziramo reverzibilnu magnetizaciju i toplinski kapacitet YBa2Cu3O7−δ u stanju “tekućine vrtloga”, i nalazimo da su oba svojstva razumno dobro opisana 3D XY modelom kritičnih fluktuacija. U velikom području polja (H) i temperatura (T), gustoća slobodne energije u stanju “tekućine vrtloga” ima osobito jednostavan oblik. To nas vodi do slike u kojoj je prisustvo kritičnih fluktuacija u visokotemperaturnim supravodičima neposredno povezano s vrlo malim brojem prekrivajućih Cooperovih parova pri T =0i H = 0, prije nego s niskom dimenzionalnošću ili visokim temperaturama

Fluktuacije faze supravodljivog uređenja u osnovnom stanju kao preduvjet jakih kritičnih fluktuacija u visokotemperaturnim supravodičima

We analyse the reversible magnetisation and heat capacity of YBa2Cu3O7−δ in the “vortex liquid” state and find that both properties are reasonably well described by the 3D XY critical-fluctuation model. The free-energy density in the “vortex liquid” state has a particularly simple form over a wide range of fields (H) and temperatures (T). This leads us to a picture in which the presence of critical fluctuations in high-Tc superconductors is directly linked to the remarkably small number of overlapping Cooper pairs at T=0 and H=0 rather than low dimensionality or high temperatures.Analiziramo reverzibilnu magnetizaciju i toplinski kapacitet YBa2Cu3O7−δ u stanju “tekućine vrtloga”, i nalazimo da su oba svojstva razumno dobro opisana 3D XY modelom kritičnih fluktuacija. U velikom području polja (H) i temperatura (T), gustoća slobodne energije u stanju “tekućine vrtloga” ima osobito jednostavan oblik. To nas vodi do slike u kojoj je prisustvo kritičnih fluktuacija u visokotemperaturnim supravodičima neposredno povezano s vrlo malim brojem prekrivajućih Cooperovih parova pri T =0i H = 0, prije nego s niskom dimenzionalnošću ili visokim temperaturama

Ground state superconducting phase fluctuations as a precursor for strong critical fluctuations in high-T_c superconductors

We analyse the reversible magnetisation and heat capacity of YBa_2Cu_3O_7-δ in the "vortex liquid" state and find that both properties are reasonably well described by the 3D XY critical-fluctuation model. The free-energy density in the "vortex liquid" state has a particularly simple form over a wide range of fields (H) and temperatures (T). This leads us to a picture in which the presence of critical fluctuations in high-T_c superconductors is directly linked to the remarkably small number of overlapping Cooper pairs at T=0 and H=0 rather than low dimensionality or high temperatures

Growth rate of YBCO single grains containing Y-2411(M)

Y-Ba-Cu-O (YBCO) single grains have the potential to generate large trapped magnetic fields for a variety of engineering applications, and research on the processing and properties of this material has attracted world-wide interest. In particular, the introduction of flux pinning centres to the large grain microstructure to improve its current density, Jc, and hence trapped field, has been investigated extensively over the past decade. Y 2Ba4CuMOx [Y-2411(M)], where M = Nb, Ta, Mo, W, Ru, Zr, Bi and Ag, has been reported to form particularly effective flux pinning centres in YBCO due primarily to its ability to exist as nano-size inclusions in the superconducting phase matrix. However, the addition of the Y-2411(M) phase to the precursor composition complicates the melt-processing of single grains. We report an investigation of the growth rate of single YBCO grains containing Y-2411(Bi) phase inclusions and Y2O3. The superconducting properties of these large single grains have been measured specifically to investigate the effect of Y2O3 on broadening the growth window of these materials

Exposure to Ranitidine and Risk of Bladder Cancer:A Nested Case-Control Study

INTRODUCTION:Ranitidine has been shown to contain the carcinogen N-nitrosodimethylamine and increase urinary N-nitrosodimethylamine in humans. We investigated whether ranitidine use is associated with increased bladder cancer risk.METHODS:A nested case-control study was conducted within the Primary Care Clinical Informatics Unit Research database which contains general practice records from Scotland. Bladder cancer cases, diagnosed between 1999 and 2011, were identified and matched with up to 5 controls (based on age, sex, general practice, and date of registration). Ranitidine, other histamine-2 receptor agonists, and proton pump inhibitors were identified from prescribing records. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression after adjusting for comorbidities and smoking.RESULTS:There were 3,260 cases and 14,037 controls. There was evidence of an increased risk of bladder cancer in ranitidine users, compared with nonusers (fully adjusted OR = 1.22; 95% CI 1.06-1.40), which was more marked with use for over 3 years of ranitidine (fully adjusted OR = 1.43; 95% CI 1.05-1.94). By contrast, there was little evidence of any association between proton pump inhibitor use and bladder cancer risk based on any use (fully adjusted OR = 0.98; 95% CI 0.88-1.11) or over 3 years of use (fully adjusted OR = 0.98; 95% CI 0.80-1.20).DISCUSSION:In this large population-based study, the use of ranitidine particularly long-term use was associated with an increased risk of bladder cancer. Further studies are necessary to attempt to replicate this finding in other settings.</p

Investigation of grain orientations of melt-textured HTSC with addition of uranium oxide, Y2O3 and Y2BaCuO5

Local grain orientations were studied in melt-textured YBCO samples processed with various amounts of depleted uranuim oxide (DU) and Y 2O3 by means of electron backscatter diffraction (EBSD) analysis. The addition of DU leads to the formation of Ucontaining nanoparticles (Y2Ba4CuUOx) with sizes of around 200 nm, embedded in the superconducting Y-123 matrix. The orientation of the Y 2BaCuO5 (Y-211) particles, which are also present in the YBCO bulk microstructure, is generally random as is the case in other melttextured Y-123 samples. The presence of Y-211 particles, however, also affects the orientation of the Y-123 matrix in these samples