Self-consistent Green's functions formalism with three-body interactions

We extend the self-consistent Green's functions formalism to take into account three-body interactions. We analyze the perturbative expansion in terms of Feynman diagrams and define effective one- and two-body interactions, which allows for a substantial reduction of the number of diagrams. The procedure can be taken as a generalization of the normal ordering of the Hamiltonian to fully correlated density matrices. We give examples up to third order in perturbation theory. To define nonperturbative approximations, we extend the equation of motion method in the presence of three-body interactions. We propose schemes that can provide nonperturbative resummation of three-body interactions. We also discuss two different extensions of the Koltun sum rule to compute the ground state of a many-body system.Comment: 26 pages, 19 figure

Mass Customization of Housing: A Framework for Harmonizing Individual Needs with Factory Produced Housing

Integrated processes for design and fabrication have guided mass customization of architectural systems and components. Providing affordable and accessible housing, a vital segment of the building industry, is a multifaceted process that witnessed various manifestations towards individualization over the past few decades. Design flexibility in housing systems is becoming a crucial aspect, informed by consumers’ lifestyles, demographic patterns, and lifecycles change at a rapid pace. As the housing market demands more personalized, efficient, and agile strategies, prefabricated building systems have always presented a viable alternative for flexibility and cus-tomization, following a rise of interest in the last decade focused on new modes of digitized design and production. This paper presents an overview and appraisal of various practices to implement customization in the housing industry, with specific focus on empowering a systemic approach. We then propose an open framework that could accommodate emergent design technologies and production protocols, with the aim of taking advantage of advanced research efforts, and coupled with current industry application

Evaluating the Utility Core in the Prefabricated Building Industry – past, present and future

Harnessing, distributing, tempering and supplying water, heat and power in a building produces its share of design, technical and coordination issues. Specifically, the relationship between hygiene and cooking functions and architecture has been underscored by even the most ancient civilizations as these services give a building its potential to serve and showcase architecture's hospitality. The relationship between services and architectural space has long challenged designers and manufacturers to streamline their piecing together. Throughout construction history and modern architecture in particular the wet service core or utility core sought to organize an efficient way of zoning services, their production and construction integration; The utility core epitomized this rationalization within a self-contained engine-like device positioned to serve the entire dwelling. This paper proposes an extensive review of literature and practical exploration in order to detect new potentials for designing integrated, technology-driven, flexible and adaptable prefabricated utility cores for today's industry. The core was intended as a hub accommodating mechanical and technological equipment; electrical services, plumbing fixtures, water supply, drain, waste, vent piping, telephone cables, and easy connections to site infrastructure. Today's techniques and building information modeling allows the core to be redefined in relation to multiple scales and various organizational possibilities with regard to space/function connections. Further an adaptable core articulated to the «open building» theoretical framework of layering systems to avoid entanglement and to maximize durability, can be part of a comprehensive strategy to enable customization. The vast amount of literature and precedents contribute to a robust historic narrative of two distinct approaches of architectural rhetoric and industrial production.  This paper will endeavor to illustrate this narrative and evaluate the potentials for achieving broader application

Fatty images of the heart: spectrum of normal and pathological findings at computed tomography and cardiac magnetic resonance imaging.

Ectopic cardiac fatty images are not rarely detected incidentally at computed tomography and cardiac magnetic resonance, either in exams focused on the heart as in general thoracic imaging evaluations. A correct interpretation of these findings is essential in order to recognize their normal or pathological meaning, focusing on the eventually associated clinical implications. The development of techniques such as computed tomography and cardiac magnetic resonance allowed a detailed detection and evaluation of adipose tissue within the heart. This pictorial review illustrates the most common characteristics of cardiac fatty images at computed tomography and cardiac magnetic resonance, in a spectrum of normal and pathological conditions ranging from physiological adipose images to diseases presenting with cardiac fatty foci. Physiologic intramyocardial adipose tissue may normally be present in healthy adults, being not related to cardiac affections and without any clinical consequence. However cardiac fatty images may also be the expression of various diseases, comprehending arrhythmogenic right ventricular dysplasia, post-myocardial infarction lipomatous metaplasia, dilated cardiomyopathy and lipomatous hypertrophy of the inter-atrial septum. Fatty neoplasms of the heart as lipoma and liposarcoma are also described

Oncogenic microRNAs characterization in clear cell renal cell carcinoma

A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management

L’architecture engagée du «Case Study House Program» de la revue Arts and Architecture de 1945 – 1966 : une confluence génératrice

La conception architecturale du logis, individuel ou collectif, est un défi majeur pour les architectes depuis l'avènement de la modernité. Au début du 21ième siècle, la multiplicité des conditions démographiques et celle de la mobilité des personnes sous-tendent la complexité de l'élaboration de prototypes ou de modèles d'habitation. Que peut-on apprendre des expériences menées dans ce domaine après la seconde guerre mondiale aux États-Unis ? Ce mémoire de maîtrise est consacré à l'étude d’un cas particulier celui du programme de création architecturale réalisée en Californie de 1945 à 1966, connu sous le nom de : «Case Study House Program». Ce programme, dirigé par John Entenza, éditeur de la revue Arts and Architecture, rassemblait de nombreux architectes dont les plus célèbres sont Charles et Ray Eames, Richard Neutra, Craig Ellwood et Pierre Koenig, tous auteurs de maisons modernes devenues oeuvres canoniques dans l’histoire de l’architecture. L'analyse détaillé de ce cas et de ses retombées devrait permettre de mieux cerner les aspects suivants: la portée critique du CSHP (case study house program) qui s'opposait aux modèles dominants du marché immobilier, modèles généralement inspirés de styles traditionnels; le potentiel et les limites d'une telle démarche face à la demande sociale; la dimension anticipatrice des propositions du CSHP pour la conception de logis mieux adaptés aux besoins du 21ième siècle, en particulier ceux qui découlent des changements démographiques et de la mobilité géographiques des personnes; la valeur d'exemple du CSHP pour mieux comprendre les fondements de la résistance du public aux innovations architecturales, autant du point de vue technique que du point de vue esthétique.Dwelling schemes, whether single family or collective have been and remain an important challenge for architects since the advent of modernism. The beginning of the 21st century has seen an explosion of lifestyles, localized demographic challenges, and an ever-changing landscape of mobility. These changes are the underlying factors that influence housing demand and the invention of new housing organizational strategies. What can be learned from the experiments undertaken, in this field, in post World War II USA ? This Master’s thesis examines the case of an initiative in architectural exploration and experimentation commanded by the Californian Arts and Architecture magazine from 1945 to 1966. «The Case Study House Program» instigated by the editor in chief John Entenza, brought together some of the most talented and engaged architects of the era including, Charles and Ray Eames, Richard Neutra, Craig Ellwood, Raphael Soriano and Pierre Koenig, all well known for their canonical contributions to the history of modern architecture. The detailed analysis and investigation of the case study houses and their influences will help reveal the critical importance of the CSHP (case study house program) on multiple levels. In its challenge to the traditional housing industry that continues to dominate the housing market today, in the program’s limitations in remaining relatively marginal in the post-war demand for housing, and in revealing the forward looking proposals and strategies in dealing with the needs of 21st century living, particularly the aspects of evolving demographic and mobility patterns. We hope to expose the value of the CSHP as an example of the potential engagement of the field of housing by architects and their essential social resistance, from an esthetic, cultural and technical point of view

Multiple Interactions between Peroxisome Proliferators-Activated Receptors and the Ubiquitin-Proteasome System and Implications for Cancer Pathogenesis

The peroxisome proliferator-activated receptors (PPAR) α, β/δ, and γ are ligand-activated nuclear receptors involved in a number of physiological processes, including lipid and glucose homeostasis, inflammation, cell growth, differentiation, and death. PPAR agonists are used in the treatment of human diseases, like type 2 diabetes and dyslipidemia, and PPARs appear as promising therapeutic targets in other conditions, including cancer. A better understanding of the functions and regulation of PPARs in normal and pathological processes is of primary importance to devise appropriate therapeutic strategies. The ubiquitin-proteasome system (UPS) plays an important role in controlling level and activity of many nuclear receptors and transcription factors. PPARs are subjected to UPS-dependent regulation. Interestingly, the three PPAR isotypes are differentially regulated by the UPS in response to ligand-dependent activation, a phenomenon that may be intrinsically connected to their distinct cellular functions and behaviors. In addition to their effects ongene expression, PPARs appear to affect protein levels and downstream pathways also by modulating the activity of the UPS in target-specific manners. Here we review the current knowledge of the interactions between the UPS and PPARs in light of the potential implications for their effects on cell fate and tumorigenesis

Impact of heart rate on myocardial salvage in timely reperfused patients with STSegment elevation myocardial infarction. new insights from cardiovascular magnetic resonance

BACKGROUND: Previous studies evaluating the progression of the necrotic wave in relation to heart rate were carried out only in animal models of ST-elevated myocardial infarction (STEMI). Aim of the study was to investigate changes of myocardial salvage in relation to different heart rates at hospital admission in timely reperfused patients with STEMI by using cardiovascular magnetic resonance (CMR). METHODS: One hundred-eighty-seven patients with STEMI successfully and timely treated with primary coronary angioplasty underwent CMR five days after hospital admission. According to the heart rate at presentation, patients were subcategorized into 5 quintiles: <55 bpm (group I, n = 44), 55-64 bpm (group II, n = 35), 65-74 bpm (group III, n = 35), 75-84 bpm (group IV, n = 37), ≥85 bpm (group V, n = 36). Area at risk, infarct size, microvascular obstruction (MVO) and myocardium salvaged index (MSI) were assessed by CMR using standard sequences. RESULTS: Lower heart rates at presentation were associated with a bigger amount of myocardial salvage after reperfusion. MSI progressively decreased as the heart rates increased (0.54 group I, 0.46 group II, 0.38 group III, 0.34 group IV, 0.32 group V, p<0.001). Stepwise multivariable analysis showed heart rate, peak troponin and the presence of MVO were independent predictor of myocardial salvage. No changes related to heart rate were observed in relation to area at risk and infarct size. CONCLUSIONS: High heart rates registered before performing coronary angioplasty in timely reperfused patients with STEMI are associated with a reduction in salvaged myocardium. In particular, salvaged myocardium significantly reduced when heart rate at presentation is ≥85 bpm