Dust Transport in Protostellar Disks Through Turbulence and Settling

We apply ionization balance and MHD calculations to investigate whether magnetic activity moderated by recombination on dust can account for the mass accretion rates and the mid-infrared spectra and variability of protostellar disks. The MHD calculations use the stratified shearing-box approach and include grain settling and the feedback from the changing dust abundance on the resistivity of the gas. The two-decade spread in accretion rates among T Tauri stars is too large to result solely from variety in the grain size and stellar X-ray luminosity, but can be produced by varying these together with the disk magnetic flux. The diversity in the silicate bands can come from the coupling of grain settling to the distribution of the magneto-rotational turbulence, through three effects: (1) Recombination on grains yields a magnetically inactive dead zone extending above two scale heights, while turbulence in the magnetically active disk atmosphere overshoots the dead zone boundary by only about one scale height. (2) Grains deep in the dead zone oscillate vertically in waves driven by the turbulent layer above, but on average settle at the laminar rates, so the interior of the dead zone is a particle sink and the disk atmosphere becomes dust-depleted. (3) With sufficient depletion, the dead zone is thinner and mixing dredges grains off the midplane. The MHD results also show that the magnetic activity intermittently lifts clouds of dust into the atmosphere. The photosphere height changes by up to one-third over a few orbits, while the extinction along lines of sight grazing the disk surface varies by factors of two over times down to 0.1 orbit. We suggest that the changing shadows cast by the dust clouds on the outer disk are a cause of the daily to monthly mid-infrared variability in some young stars. (Abridged.)Comment: ApJ in pres

Validation of the 3-under-2 principle of cell wall growth in Gram-positive bacteria by simulation of a simple coarse-grained model

The aim of this work is to propose a first coarse-grained model of Bacillus subtilis cell wall, handling explicitly the existence of multiple layers of peptidoglycans. In this first work, we aim at the validation of the recently proposed "three under two" principle.Comment: Revised introduction, results unchange

Net community production of oxygen derived from in vitro and in situ 1-D modeling techniques in a cyclonic mesoscale eddy in the Sargasso Sea

© 2009 The Authors. This work is distributed under the Creative Commons Attribution 3.0 License. The definitive version was published in Biogeosciences 6 (2009): 1799-1810, doi:10.5194/bg-6-1799-2009It has been proposed that the disagreement traditionally reported between in vitro incubation and in situ estimates of oxygen net community production (NCP) could be explained, at least partially, by undersampling episodic pulses of net autotrophy associated with mesoscale dynamics. In this study we compare in vitro incubation estimates of net community production with in situ estimates, derived from oxygen profiles and a 1-D model, within a cyclonic eddy investigated in the Sargasso Sea in summer 2004. The in vitro NCP rates measured at the center of the eddy showed a shift from net autotrophy (7±3 mmol O2 m−2 d−1) to net heterotrophy (−25±5 mmol O2 m−2 d−1) from late June to early August. The model-derived NCP rates also showed a temporal decline (19±6 to −3±7 and 11±8 mmol O2 m−2 d−1), but they were systematically higher than the in vitro estimates and reported net autotrophy or balance for the sampling period. In this comparison episodic pulses in photosynthesis or respiration driven by mesoscale eddies can not explain the discrepancy between the in vitro and in situ estimates of NCP. This points to methodological artefacts or temporal or submesoscale variability as the mechanisms responsible for the disagreement between the techniques, at least in this dataset.B. Mourino-Carballido was supported by a Fulbright postdoctoral fellowship and the Isidro Parga Pondal program from the Galician government

Discovering time-lagged rules from microarray data using gene profile classifiers

Background: Gene regulatory networks have an essential role in every process of life. In this regard, the amount of genome-wide time series data is becoming increasingly available, providing the opportunity to discover the time-delayed gene regulatory networks that govern the majority of these molecular processes.Results: This paper aims at reconstructing gene regulatory networks from multiple genome-wide microarray time series datasets. In this sense, a new model-free algorithm called GRNCOP2 (Gene Regulatory Network inference by Combinatorial OPtimization 2), which is a significant evolution of the GRNCOP algorithm, was developed using combinatorial optimization of gene profile classifiers. The method is capable of inferring potential time-delay relationships with any span of time between genes from various time series datasets given as input. The proposed algorithm was applied to time series data composed of twenty yeast genes that are highly relevant for the cell-cycle study, and the results were compared against several related approaches. The outcomes have shown that GRNCOP2 outperforms the contrasted methods in terms of the proposed metrics, and that the results are consistent with previous biological knowledge. Additionally, a genome-wide study on multiple publicly available time series data was performed. In this case, the experimentation has exhibited the soundness and scalability of the new method which inferred highly-related statistically-significant gene associations.Conclusions: A novel method for inferring time-delayed gene regulatory networks from genome-wide time series datasets is proposed in this paper. The method was carefully validated with several publicly available data sets. The results have demonstrated that the algorithm constitutes a usable model-free approach capable of predicting meaningful relationships between genes, revealing the time-trends of gene regulation. © 2011 Gallo et al; licensee BioMed Central Ltd.Fil: Gallo, Cristian Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; ArgentinaFil: Carballido, Jessica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; ArgentinaFil: Ponzoni, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación; Argentin

Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice

The inflammatory response is normally limited by mechanisms regulating its resolution. In the absence of resolution, inflammatory pathologies can emerge, resulting in substantial morbidity and mortality. We have been studying the D6 chemokine scavenging receptor, which played an indispensable role in the resolution phase of inflammatory responses and does so by facilitating removal of inflammatory CC chemokines. In D6-deficient mice, otherwise innocuous cutaneous inflammatory stimuli induce a grossly exaggerated inflammatory response that bears many similarities to human psoriasis. In the present study, we have used transcriptomic approaches to define the molecular make up of this response. The data presented highlight potential roles for a number of cytokines in initiating and maintaining the psoriasis-like pathology. Most compellingly, we provide data indicating a key role for the type I interferon pathway in the emergence of this pathology. Neutralizing antibodies to type I interferons are able to ameliorate the psoriasis-like pathology, confirming a role in its development. Comparison of transcriptional data generated from this mouse model with equivalent data obtained from human psoriasis further demonstrates the strong similarities between the experimental and clinical systems. As such, the transcriptional data obtained in this preclinical model provide insights into the cytokine network active in exaggerated inflammatory responses and offer an excellent tool to evaluate the efficacy of compounds designed to therapeutically interfere with inflammatory processes

A new rebbachisaurid sauropod from the Aptian–Albian, Lower Cretaceous Rayoso Formation, Neuquén, Argentina

Rebbachisaurids are a group of basal diplodocimorph sauropods that diversified in Gondwana at the end of the Early Cretaceous and the beginning of the Late Cretaceous. It is a group of great palaeobiogeographical interest, for it clearly illustrates various processes of dispersal throughout Gondwana and to Laurasia prior to the breakup of Africa and South America. However, the relationships within the group are still under discussion owing to the scarcity of cranial material that would help clarify them. In the present paper we describe the new rebbachisaurid Lavocatisaurus agrioensis gen. et sp. nov. from the Aptian–Albian (Lower Cretaceous) of Neuquén (Argentina). Remains have been recovered belonging to an adult specimen (holotype) and two immature specimens (paratypes). Taken together, almost all the bones of the taxon are represented, including most of the cranium. Lavocatisaurus agrioensis gen. et sp. nov. is the first rebbachisaurid from Argentina with an almost complete cranium, making it possible to recognize differences with respect to other rebbachisaurids, such as the highly derived Nigersaurus. Among its most notable characters are the presences of a large preantorbital fenestra and maxillary teeth that are significantly larger than those of the dentary. Our phylogenetic study places Lavocatisaurus amongst basal rebbachisaurids, as the sister lineage to Khebbashia (the clade formed by Limaysaurinae + Rebbachisaurinae). This position, which is somewhat more derived than that previously suggested for Comahuesaurus and Zapalasaurus (the Argentinean rebbachisaurids closest in geographical and geological terms), reaffirms the presence of different basal rebbachisaurid lineages in the Early Cretaceous of Patagonia

Control of a wind turbine equipped with a variable rotor resistance

In this thesis the control of a wind turbine equipped with an induction generator with variable rotor resistances was investigated. Analysis, modelling and control of the induction generator system was conducted. In particular the focus was put on the reduction of torque fluctuations, in order to reduce the stresses in the gearbox and in the mechanical structure as well as reducing the flicker emission. Different controlling methods were studied in order to find an appropriate choice. Finally, the induction machine with the variable rotor resistance controller was compared with the same induction machine without controller for the wind application, in order to study the improvement of implementing the controller. The first thing to be emphasized is that by utilising the controller the flicker contribution can be reduced between 35%‐60% compared to the uncontrolled system. It was also found that the reduction of the flicker contributions was strongly related with the turbulence intensity in the wind. The reduction in the flicker emission was stronger for more turbulent winds. Furthermore, a reduction in the magnitude of the electrical torque components for the frequencies above 1Hz was found. Those high‐frequency components are the ones that more contribute to the mechanical stresses in the gearbox and structure of the turbine, this means that by utilising the controller there will be less tear and wear on the mechanical parts of the turbine. _____________________________________________________En este proyecto final de carrera se ha investigado el control de una turbina de viento equipada con un generador de inducción, que a su vez está equipado con resistencias del rotor variables. En el mismo, el análisis, modelado y control del generador de inducción ha sido llevado a cabo. En particular, el mayor interés del proyecto se puso en la reducción de las fluctuaciones del par generado por el generador de inducción, para así reducir el estrés mecánico tanto en la caja de cambios como en la estructura mecánica, así como reducir las fluctuaciones en la potencia entregada a la red. Diferentes métodos de control fueron estudiados para encontrar la elección más adecuada. Una vez seleccionado el método de control que se iba a emplear, Se compararon los resultados obtenidos con la maquina de inducción donde se había implementado el controlador de las resistencias variables, con la misma máquina de inducción sin el controlador. Esta comparación se realizó para estudiar la mejora que se obtenía al utilizar el controlador.Ingeniería Industria