1,061 research outputs found
de Sitter gravity from lattice gauge theory
We investigate a lattice model for Euclidean quantum gravity based on
discretization of the Palatini formulation of General Relativity. Using Monte
Carlo simulation we show that while a naive approach fails to lead to a vacuum
state consistent with the emergence of classical spacetime, this problem may be
evaded if the lattice action is supplemented by an appropriate counter term. In
this new model we find regions of the parameter space which admit a ground
state which can be interpreted as (Euclidean) de Sitter space.Comment: 16 pages, 11 figures. email address update
Explicit characterization of the identity configuration in an Abelian Sandpile Model
Since the work of Creutz, identifying the group identities for the Abelian
Sandpile Model (ASM) on a given lattice is a puzzling issue: on rectangular
portions of Z^2 complex quasi-self-similar structures arise. We study the ASM
on the square lattice, in different geometries, and a variant with directed
edges. Cylinders, through their extra symmetry, allow an easy determination of
the identity, which is a homogeneous function. The directed variant on square
geometry shows a remarkable exact structure, asymptotically self-similar.Comment: 11 pages, 8 figure
A General Limitation on Monte Carlo Algorithms of Metropolis Type
We prove that for any Monte Carlo algorithm of Metropolis type, the
autocorrelation time of a suitable ``energy''-like observable is bounded below
by a multiple of the corresponding ``specific heat''. This bound does not
depend on whether the proposed moves are local or non-local; it depends only on
the distance between the desired probability distribution and the
probability distribution for which the proposal matrix satisfies
detailed balance. We show, with several examples, that this result is
particularly powerful when applied to non-local algorithms.Comment: 8 pages, LaTeX plus subeqnarray.sty (included at end),
NYU-TH-93/07/01, IFUP-TH33/9
Nanoparticles-cell association predicted by protein corona fingerprints
In a physiological environment (e.g., blood and interstitial fluids) nanoparticles (NPs) will bind proteins shaping a "protein corona" layer. The long-lived protein layer tightly bound to the NP surface is referred to as the hard corona (HC) and encodes information that controls NP bioactivity (e.g. cellular association, cellular signaling pathways, biodistribution, and toxicity). Decrypting this complex code has become a priority to predict the NP biological outcomes. Here, we use a library of 16 lipid NPs of varying size (Ø ≈ 100-250 nm) and surface chemistry (unmodified and PEGylated) to investigate the relationships between NP physicochemical properties (nanoparticle size, aggregation state and surface charge), protein corona fingerprints (PCFs), and NP-cell association. We found out that none of the NPs' physicochemical properties alone was exclusively able to account for association with human cervical cancer cell line (HeLa). For the entire library of NPs, a total of 436 distinct serum proteins were detected. We developed a predictive-validation modeling that provides a means of assessing the relative significance of the identified corona proteins. Interestingly, a minor fraction of the HC, which consists of only 8 PCFs were identified as main promoters of NP association with HeLa cells. Remarkably, identified PCFs have several receptors with high level of expression on the plasma membrane of HeLa cells
Nanoparticles-cell association predicted by protein corona fingerprints
In a physiological environment (e.g., blood and interstitial fluids) nanoparticles (NPs) will bind proteins shaping a "protein corona" layer. The long-lived protein layer tightly bound to the NP surface is referred to as the hard corona (HC) and encodes information that controls NP bioactivity (e.g. cellular association, cellular signaling pathways, biodistribution, and toxicity). Decrypting this complex code has become a priority to predict the NP biological outcomes. Here, we use a library of 16 lipid NPs of varying size (Ø ≈ 100-250 nm) and surface chemistry (unmodified and PEGylated) to investigate the relationships between NP physicochemical properties (nanoparticle size, aggregation state and surface charge), protein corona fingerprints (PCFs), and NP-cell association. We found out that none of the NPs' physicochemical properties alone was exclusively able to account for association with human cervical cancer cell line (HeLa). For the entire library of NPs, a total of 436 distinct serum proteins were detected. We developed a predictive-validation modeling that provides a means of assessing the relative significance of the identified corona proteins. Interestingly, a minor fraction of the HC, which consists of only 8 PCFs were identified as main promoters of NP association with HeLa cells. Remarkably, identified PCFs have several receptors with high level of expression on the plasma membrane of HeLa cells
Cryogenic light detectors with enhanced performance for rare events physics
We have developed and tested a new way of coupling bolometric light detectors
to scintillating crystal bolometers based upon simply resting the light
detector on the crystal surface, held in position only by gravity. This
straightforward mounting results in three important improvements: (1) it
decreases the amount of non-active materials needed to assemble the detector,
(2) it substantially increases the light collection efficiency by minimizing
the light losses induced by the mounting structure, and (3) it enhances the
thermal signal induced in the light detector thanks to the extremely weak
thermal link to the thermal bath. We tested this new technique with a 16 cm
Ge light detector with thermistor readout sitting on the surface of a large
TeO bolometer. The light collection efficiency was increased by greater
than 50\% compared to previously tested alternative mountings. We obtained a
baseline energy resolution on the light detector of 20~eV RMS that, together
with increased light collection, enabled us to obtain the best vs
discrimination ever obtained with massive TeO crystals. At
the same time we achieved rise and decay times of 0.8 and 1.6 ms, respectively.
This superb performance meets all of the requirements for the CUPID (CUORE
Upgrade with Particle IDentification) experiment, which is a 1-ton
scintillating bolometer follow up to CUORE.Comment: 6 pages, 4 figure
Modelling the shrub encroachment in a grassland with a Cellular Automata Model
Abstract. Arid and semi-arid grasslands of southwestern North America have changed dramatically over the last 150 years as a result of shrub encroachment, i.e. the increase in density, cover and biomass of indigenous shrubby plants in grasslands. Numerous studies have documented the expansion of shrublands in the southwestern American grasslands; in particular shrub encroachment has occurred strongly in part of the northern Chihuahuan desert since 1860. This encroachment has been simulated using an ecohydrological Cellular Automata model, CATGraSS. It is a spatially distributed model driven by spatially explicit irradiance and runs on a fine-resolution gridded domain. Plant competition is modelled by keeping track of mortality and establishment of plants; both are calculated probabilistically based on soil moisture stress. For this study CATGraSS has been improved with a stochastic fire module and a grazing function. The model has been implemented in a small area in Sevilleta National Wildlife Refuge (SNWR), characterized by two vegetation types (grass savanna and creosote bush shrub), considering as encroachment causes the fire return period increase, the grazing increase, the seed dispersal caused by animals, the role of wind direction and plant type competition. The model is able to reproduce the encroachment that has occurred in SNWR, simulating an increase of the shrub from 2% in 1860 to the current shrub percentage, 42%, and highlighting among the most influential factors the reduced fire frequency and the increased grazing intensity
The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population
OBJECTIVE:
To investigate the symptom of low mood as a predictor of mild cognitive impairment (MCI) and its progression to dementia, taking into account: (i) MCI severity, (ii) time of assessment and (iii) interaction with other factors.
METHODS:
764 cognitively healthy elderly subjects living in the community, from the Kungsholmen Project. Participants were assessed by direct interview to detect low mood. Subjects were then followed for 6 years to identify those who developed MCI. People with incident MCI were followed for a further 3 years to assess progression to dementia.
RESULTS:
People with low mood at baseline had a 2.7-fold (95% CI 1.9 to 3.7) increased risk of developing MCI at follow-up. The association was stronger for amnestic MCI (aMCI: HR 5.8; 95% CI 3.1 to 10.9) compared with global cognitive impairment (other cognitive impairment no dementia, oCIND: HR 2.2; 95% CI 1.5 to 3.3). ApoE-ε4 interacted with low mood in a synergistic fashion, increasing the risk of aMCI, while no interaction with psychiatric, vascular, frailty related or psychosocial factors was observed. Low mood at baseline, as opposed to low mood co-occurring with MCI, was associated with a 5.3-fold (95% CI 1.2 to 23.3) increased risk of progression to dementia in aMCI. In contrast, no association was found in oCIND.
CONCLUSION:
Low mood was more strongly associated with aMCI than with global cognitive impairment. Progression towards dementia was predicted only by low mood manifest in the prodromal stage of MCI. These findings indicate that low mood is particularly prominent in the very early stages of cognitive decline
Unquenched Numerical Stochastic Perturbation Theory
The inclusion of fermionic loops contribution in Numerical Stochastic
Perturbation Theory (NSPT) has a nice feature: it does not cost so much
(provided only that an FFT can be implemented in a fairly efficient way).
Focusing on Lattice SU(3), we report on the performance of the current
implementation of the algorithm and the status of first computations
undertaken.Comment: 3 pages, 3 figures, Lattice2002(algor
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