Perioperative Cerebral Microbleeds After Adult Cardiac Surgery.

Background and Purpose- Cerebral microbleeds (CMBs) have been observed using magnetic resonance imaging in patients with cardiovascular risk factors, cognitive deterioration, small vessel disease, and dementia. They are a well-known consequence of cerebral amyloid angiopathy, chronic hypertension, and diffuse axonal injury, among other causes. However, the frequency and location of new CMBs postadult cardiac surgery, in association with cognition and perioperative risk factors, have yet to be studied. Methods- Pre- and postsurgery magnetic resonance susceptibility-weighted images and neuropsychological tests were analyzed from a total of 75 patients undergoing cardiac surgery (70 men; mean age, 63±10 years). CMBs were identified by a neuroradiologist blinded to clinical details who independently assessed the presence and location of CMBs using standardized criteria. Results- New CMBs were identified in 76% of patients after cardiac surgery. The majority of new CMBs were located in the frontal lobe (46%) followed by the parietal lobe (15%), cerebellum (13%), occipital lobe (12%), and temporal lobe (8%). Patients with new CMBs typically began with a higher prevalence of preexisting CMBs ( P=0.02). New CMBs were associated with longer cardiopulmonary bypass times ( P=0.003), and there was a borderline association with lower percentage hematocrit ( P=0.04). Logistic regression analysis suggested a ≈2% increase in the odds of acquiring new CMBs during cardiac surgery for every minute of bypass time (odds ratio, 1.02; 95% CI, 1.00-1.05; P=0.04). Postoperative neuropsychological decline was observed in 44% of patients and seemed to be unrelated to new CMBs. Conclusions- New CMBs identified using susceptibility-weighted images were found in 76% of patients who underwent cardiac surgery. CMBs were globally distributed with the highest numbers in the frontal and parietal lobes. Our regression analysis indicated that length of cardiopulmonary bypass time and lowered hematocrit may be significant predictors for new CMBs after cardiac surgery. Clinical Trial Registration- URL: http://www.isrctn.com . Unique identifier: 66022965

Modelisation of Light Transmission through Surfaces with Thin Film Optical Coating in Geant4

International audienceSurfaces with optical coating may be used to improve light transmission between a scintillating crystal and a photodetector. For the ClearMind project, we develop a detection module made of a PbWO4 crystal and a photocathode directly deposited on a thin passivation film coating the crystal face. Scintillation photons will then be transmitted through this thin film that has a thickness of the order of the scintillation light wavelength. Interference phenomena and frustrated transmission beyond the limit angle have then to be considered. We present the modelisation of light transmission through surfaces with optical coating with Geant4, which is achieved by defining a new method that provides a probability of transmission of a visible-UV photons through the coated interfac

First ClearMind gamma detector prototype for TOF-PET imaging

International audienceThe ClearMind project aims to develop a TOF-PET position-sensitive detection module optimized for time and spatial resolutions and detection efficiency. For this, we use a 59 mm $\times$ 59 mm $\times$ 5 mm monolithic PbWO$_4$ (PWO) crystal, which is encapsulated within a commercial Micro-Channel Plate Photomultiplier tube MAPMT253 with a bialkali photocathode directly deposited on the crystal. We report the proof of concept of the directly deposited of a bialkali photocathode on a PWO crystal and its stability over time. The full calibration of the ClearMind photodetector module in the single-photoelectron regime is described. We measured a time resolution of 70 ps FWHM using a 20 ps pulsed laser. We present the performance of the prototype used in coincidence with a 3 $\times$ 3 $\times$ 3 mm$^3$ LYSO:Ca,Ce crystal readout by a SiPM. We obtained a coincidence time resolution of 350 ps FWHM, a spatial resolution of 4 to 5 mm, and a detection efficiency of 28 %, consistent with Monte Carlo simulations of the ClearMind detector module

First ClearMind gamma detector prototype for TOF-PET imaging

International audienceThe ClearMind project aims to develop a TOF-PET position-sensitive detection module optimized for time and spatial resolutions and detection efficiency. For this, we use a 59 mm $\times$ 59 mm $\times$ 5 mm monolithic PbWO$_4$ (PWO) crystal, which is encapsulated within a commercial Micro-Channel Plate Photomultiplier tube MAPMT253 with a bialkali photocathode directly deposited on the crystal. We report the proof of concept of the directly deposited of a bialkali photocathode on a PWO crystal and its stability over time. The full calibration of the ClearMind photodetector module in the single-photoelectron regime is described. We measured a time resolution of 70 ps FWHM using a 20 ps pulsed laser. We present the performance of the prototype used in coincidence with a 3 $\times$ 3 $\times$ 3 mm$^3$ LYSO:Ca,Ce crystal readout by a SiPM. We obtained a coincidence time resolution of 350 ps FWHM, a spatial resolution of 4 to 5 mm, and a detection efficiency of 28 %, consistent with Monte Carlo simulations of the ClearMind detector module

First ClearMind gamma detector prototype for TOF-PET imaging

International audienceThe ClearMind project aims to develop a TOF-PET position-sensitive detection module optimized for time and spatial resolutions and detection efficiency. For this, we use a 59 mm $\times$ 59 mm $\times$ 5 mm monolithic PbWO$_4$ (PWO) crystal, which is encapsulated within a commercial Micro-Channel Plate Photomultiplier tube MAPMT253 with a bialkali photocathode directly deposited on the crystal. We report the proof of concept of the directly deposited of a bialkali photocathode on a PWO crystal and its stability over time. The full calibration of the ClearMind photodetector module in the single-photoelectron regime is described. We measured a time resolution of 70 ps FWHM using a 20 ps pulsed laser. We present the performance of the prototype used in coincidence with a 3 $\times$ 3 $\times$ 3 mm$^3$ LYSO:Ca,Ce crystal readout by a SiPM. We obtained a coincidence time resolution of 350 ps FWHM, a spatial resolution of 4 to 5 mm, and a detection efficiency of 28 %, consistent with Monte Carlo simulations of the ClearMind detector module

Detailed simulation for the ClearMind prototype detection module and event reconstruction using artificial intelligence

The ClearMind project aims to develop the TOF-PET position sensitive detection module optimized for the time resolution, spatial resolution, and detection efficiency. For this, the ClearMind project uses a large (59 $\times$ 59 mm$^2$) monolithic PbWO$_4$ (PWO) scintillating crystal with a bialkali photo-electric layer deposited directly on the crystal. Scintillation and Cherenkov photons result together from the 511 keV gamma-ray interation into the PWO crystal. A micro-channel plate photomultiplier tube (MCP-PMT) encapsulating the PWO crystal amplifies photoelectrons generated at the photocathode, and the corresponding anode signals are collected through the transmission lines read out at both ends and digitized by a SAMPIC module. In this work, we present a realistic Geant4 simulation of the ClearMind prototype detector, including the propagation of the visible photons in the crystal, the modelling of a realistic response of the photocathode and of the PMT, and the propagation of the electrical signals over the transmission lines. The reconstruction of the gamma conversion in the detector volume is performed from the signals registered at both ends of the transmission lines. We compare the reconstruction precision of a statistical algorithm against machine learning algorithms developed using the TVMA package. We expect to reach a spatial resolution down to a few mm$^3$ (FWHM). Finally, we will discuss prospects for the ClearMind detector

Detailed simulation for the ClearMind prototype detection module and event reconstruction using artificial intelligence

The ClearMind project aims to develop the TOF-PET position sensitive detection module optimized for the time resolution, spatial resolution, and detection efficiency. For this, the ClearMind project uses a large (59 $\times$ 59 mm$^2$) monolithic PbWO$_4$ (PWO) scintillating crystal with a bialkali photo-electric layer deposited directly on the crystal. Scintillation and Cherenkov photons result together from the 511 keV gamma-ray interation into the PWO crystal. A micro-channel plate photomultiplier tube (MCP-PMT) encapsulating the PWO crystal amplifies photoelectrons generated at the photocathode, and the corresponding anode signals are collected through the transmission lines read out at both ends and digitized by a SAMPIC module. In this work, we present a realistic Geant4 simulation of the ClearMind prototype detector, including the propagation of the visible photons in the crystal, the modelling of a realistic response of the photocathode and of the PMT, and the propagation of the electrical signals over the transmission lines. The reconstruction of the gamma conversion in the detector volume is performed from the signals registered at both ends of the transmission lines. We compare the reconstruction precision of a statistical algorithm against machine learning algorithms developed using the TVMA package. We expect to reach a spatial resolution down to a few mm$^3$ (FWHM). Finally, we will discuss prospects for the ClearMind detector

Detailed simulation for the ClearMind prototype detection module and event reconstruction using artificial intelligence

The ClearMind project aims to develop the TOF-PET position sensitive detection module optimized for the time resolution, spatial resolution, and detection efficiency. For this, the ClearMind project uses a large (59 $\times$ 59 mm$^2$) monolithic PbWO$_4$ (PWO) scintillating crystal with a bialkali photo-electric layer deposited directly on the crystal. Scintillation and Cherenkov photons result together from the 511 keV gamma-ray interation into the PWO crystal. A micro-channel plate photomultiplier tube (MCP-PMT) encapsulating the PWO crystal amplifies photoelectrons generated at the photocathode, and the corresponding anode signals are collected through the transmission lines read out at both ends and digitized by a SAMPIC module. In this work, we present a realistic Geant4 simulation of the ClearMind prototype detector, including the propagation of the visible photons in the crystal, the modelling of a realistic response of the photocathode and of the PMT, and the propagation of the electrical signals over the transmission lines. The reconstruction of the gamma conversion in the detector volume is performed from the signals registered at both ends of the transmission lines. We compare the reconstruction precision of a statistical algorithm against machine learning algorithms developed using the TVMA package. We expect to reach a spatial resolution down to a few mm$^3$ (FWHM). Finally, we will discuss prospects for the ClearMind detector