2,711 research outputs found
Assessment of poststress left ventricular ejection fraction by gated SPECT: comparison with equilibrium radionuclide angiocardiography
PURPOSE: We compared left ventricular (LV) ejection fraction obtained by gated SPECT with that obtained by equilibrium radionuclide angiocardiography in a large cohort of patients.
METHODS: Within 1 week, 514 subjects with suspected or known coronary artery disease underwent same-day stress-rest (99m)Tc-sestamibi gated SPECT and radionuclide angiocardiography. For both studies, data were acquired 30 min after completion of exercise and after 3 h rest.
RESULTS: In the overall study population, a good correlation between ejection fraction measured by gated SPECT and by radionuclide angiocardiography was observed at rest (r=0.82, p<0.0001) and after stress (r=0.83, p<0.0001). In Bland-Altman analysis, the mean differences in ejection fraction (radionuclide angiocardiography minus gated SPECT) were -0.6% at rest and 1.7% after stress. In subjects with normal perfusion (n=362), a good correlation between ejection fraction measured by gated SPECT and by radionuclide angiocardiography was observed at rest (r=0.72, p<0.0001) and after stress (r=0.70, p<0.0001) and the mean differences in ejection fraction were -0.9% at rest and 1.4% after stress. Also in patients with abnormal perfusion (n=152), a good correlation between the two techniques was observed both at rest (r=0.89, p<0.0001) and after stress (r=0.90, p<0.0001) and the mean differences in ejection fraction were 0.1% at rest and 2.5% after stress.
CONCLUSION: In a large study population, a good agreement was observed in the evaluation of LV ejection fraction between gated SPECT and radionuclide angiocardiography. However, in patients with perfusion abnormalities, a slight underestimation in poststress LV ejection fraction was observed using gated SPECT as compared to equilibrium radionuclide angiocardiography
Spatial differentiation in industrial dynamics : a core-periphery analysis based on the Pavitt-Miozzo-Soete taxonomy
We compare the industrial dynamics in the core, semi-periphery and periphery in The Netherlands in terms of firm entry-exit, size, growth and sectoral location patterns. The contribution of our work is to provide the first comprehensive study on spatial differentiation in industrial dynamics for all firm sizes and all sectors, including services. We find that at the aggregate level the spatial pattern of industrial dynamics is consistent with the spatial product lifecycle thesis: entry and exit rates are highest in the core and lowest in the periphery, while the share of persistently growing firms is higher in the periphery than in the core. Disaggregating the analysis to the sectoral level following the Pavitt-Miozzo-Soete taxonomy, findings are less robust. Finally, sectoral location patterns are largely consistent with the spatial product lifecycle model: Fordist sectors are over-represented in the periphery, while sectors associated with the ICT paradigm are over-represented in the core, with the notable exception of science-based manufacturing
Orientation-dependent Casimir force arising from highly anisotropic crystals: application to Bi2Sr2CaCu2O8+delta
We calculate the Casimir interaction between parallel planar crystals of Au
and the anisotropic cuprate superconductor Bi2Sr2CaCu2O8+delta (BSCCO), with
BSCCO's optical axis either parallel or perpendicular to the crystal surface,
using suitable generalizations of the Lifshitz theory. We find that the strong
anisotropy of the BSCCO permittivity gives rise to a difference in the Casimir
force between the two orientations of the optical axis, which depends on
distance and is of order 10-20% at the experimentally accessible separations 10
to 5000 nm.Comment: 5 pages, 3 figures. Accepted for publication in Physical Review
High-Power Directional Emission from Microlasers with Chaotic Resonators
High-power and highly directional semiconductor cylinder-lasers based on an
optical resonator with deformed cross section are reported. In the favorable
directions of the far-field, a power increase of up to three orders of
magnitude over the conventional circularly symmetric lasers was obtained. A
"bow-tie"-shaped resonance is responsible for the improved performance of the
lasers in the higher range of deformations, in contrast to
"whispering-gallery"-type modes of circular and weakly deformed lasers. This
resonator design, although demonstrated here in midinfrared quantum-cascade
lasers, should be applicable to any laser based on semiconductors or other
high-refractive index materials.Comment: Removed minor discrepancies with published version in the text and in
Fig.
Quantum-Coherence-Enhanced Surface Plasmon Amplification by Stimulated Emission of Radiation
We investigate surface plasmon amplification in a silver nanoparticle coupled
to an externally driven three-level gain medium, and show that quantum
coherence significantly enhances the generation of surface plasmons. Surface
plasmon amplification by stimulated emission of radiation is achieved in the
absence of population inversion on the spasing transition, which reduces the
pump requirements. The coherent drive allows us to control the dynamics, and
holds promise for quantum control of nanoplasmonic devices.Comment: 5 pages, 4 figure
Computation and visualization of Casimir forces in arbitrary geometries: non-monotonic lateral forces and failure of proximity-force approximations
We present a method of computing Casimir forces for arbitrary geometries,
with any desired accuracy, that can directly exploit the efficiency of standard
numerical-electromagnetism techniques. Using the simplest possible
finite-difference implementation of this approach, we obtain both agreement
with past results for cylinder-plate geometries, and also present results for
new geometries. In particular, we examine a piston-like problem involving two
dielectric and metallic squares sliding between two metallic walls, in two and
three dimensions, respectively, and demonstrate non-additive and non-monotonic
changes in the force due to these lateral walls.Comment: Accepted for publication in Physical Review Letters. (Expected
publication: Vol. 99 (8) 2007
Precision measurement of the Casimir-Lifshitz force in a fluid
The Casimir force, which results from the confinement of the quantum
mechanical zero-point fluctuations of the electromagnetic fields, has received
significant attention in recent years for its effect on micro- and nano-scale
mechanical systems. With few exceptions, experimental observations have been
limited to conductive bodies interacting separated by vacuum or air. However,
interesting phenomena including repulsive forces are expected to exist in
certain circumstances between metals and dielectrics when the intervening
medium is not vacuum. In order to better understand the effect of the Casimir
force in such situations and to test the robustness of the generalized
Casimir-Lifshitz theory, we have performed the first precision measurements of
the Casimir force between two metals immersed in a fluid. For this situation,
the measured force is attractive and is approximately 80% smaller than the
force predicted by Casimir for ideal metals in vacuum. We present experimental
results and find them to be consistent with Lifshitz's theory.Comment: 6 pages, 3 figures. (version before final publication
The omnivorous Tyrolean Iceman: colon contents (meat, cereals, pollen, moss and whipworm) and stable isotope analyses
The contents of the colon of the Tyrolean Iceman who lived Ga. 5300 years ago include muscle fibres, cereal remains, a diversity of pollen, and most notably that of the hop hornbeam (Ostrya carpinifolia) retaining cellular contents, as well as a moss leaf (Neckera complanata) and eggs of the parasitic whipworm (Trichuris trichiura). Based almost solely on stable isotope analyses and ignoring the work on the colon contents, two recently published papers on the Iceman's diet draw ill- founded conclusions about vegetarianism and even veganism. Neither the pollen nor the moss is likely to have been deliberately consumed as food by the Iceman. All the available evidence concerning the Iceman's broad-based diet is reviewed and the significance of the colon contents for matters other than assessment of food intake is outlined
Predicting protein decomposition: the case of aspartic-acid racemization kinetics
The increase in proportion of the non-biological (D-) isomer of aspartic acid (Asp) relative to the L- isomer has been widely used in archaeology and geochemistry as a tool for dating. The method has proved controversial, particularly when used for bones. The non-linear kinetics of Asp racemization have prompted a number of suggestions as to the underlying mechanism(s) and have led to the use of mathe- matical transformations which linearize the increase in D-Asp with respect to time. Using one example, a suggestion that the initial rapid phase of Asp racemization is due to a contribution from asparagine (Asn), we demonstrate how a simple model of the degradation and racemization of Asn can be used to predict the observed kinetics. A more complex model of peptide bound Asx (Asn+Asp) racemization, which occurs via the formation of a cyclic succinimide (Asu), can be used to correctly predict Asx racemi- zation kinetics in proteins at high temperatures (95-140 °C). The model fails to predict racemization kinetics in dentine collagen at 37 °C. The reason for this is that Asu formation is highly conformation dependent and is predicted to occur extremely slowly in triple helical collagen. As conformation strongly in£uences the rate of Asu formation and hence Asx racemization, the use of extrapolation from high temperatures to estimate racemization kinetics of Asx in proteins below their denaturation temperature is called into question. In the case of archaeological bone, we argue that the D:L ratio of Asx re£ects the proportion of non- helical to helical collagen, overlain by the e¡ects of leaching of more soluble (and conformationally unconstrained) peptides. Thus, racemization kinetics in bone are potentially unpredictable, and the proposed use of Asx racemization to estimate the extent of DNA depurination in archaeological bones is challenged
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