A Novel Glycoside from Acanthus hirsutus (Acanthaceae)

WOS: 000276598500014PubMed ID: 20433073A novel glycoside, hirsutusoide (1), characterized as 2-(o-hydroxyphenyl)-2-hydroxyethenyl-O-beta-glucopyranoside, was isolated from the endemic Acanthus hirsutus Boiss. In addition to compound 1, three known glycosides, luteolin-7-O-beta-D-glucuronide (2), beta-sitosterol-3-O-beta-D-glucopyranoside (3) and (2R)-2-O-beta-D-glucopyranosyl-2H-1,4-benzoxazin-3(4H)-one (4), were also isolated. Compound 2 was the first report from this genus. Antimicrobial and antioxidant activity of the extracts and the novel compound were investigated by determining MIC (mu g/mL) and IC50 (mu g/mL) values, respectively.Ege University Research Fund AccountancyEge University [2008/FEN/047]The authors are grateful to Asst. Prof. Levent SIK for collection and identification of the plant, Prof. Dr. Nazli ARDA for discussing antioxidant activity results and also to Ege University Research Fund Accountancy (2008/FEN/047) of Turkey for financial support. The authors thank to Assoc. Prof. Dr Stephen ASTLEY for proof reading the manuscript