Polarized Proton Pionic Capture in Deuterium as a Probe of 3N Dynamics

The proton analyzing power Ay in pion production reaction pd --> pi0 3He has been calculated including one- and two-body meson production mechanisms with a proper treatment of the three-nucleon dynamics and an accurate solution of the 3N bound-state problem for phenomenological two-nucleon potentials. In the region around the Delta resonance, the structure of the analyzing power can be understood once interference effects among amplitudes describing intermediate Delta N formation in different orbital states are considered along with the additional interference with the S-wave pion production amplitudes. Then, the inclusion of three-nucleon dynamics in the initial state produces the structure of the analyzing power that has been observed experimentally.Comment: 9 pages, 5 figure

Particle-unstable light nuclei with a Sturmian approach that preserves the Pauli principle

Sturmian theory for nucleon-nucleus scattering is discussed in the presence of all the phenomenological ingredients necessary for the description of weakly-bound (or particle-unstable) light nuclear systems. Currently, we use a macroscopic potential model of collective nature. The analysis shows that the couplings to low-energy collective-core excitations are fundamental but they are physically meaningful only if the constraints introduced by the Pauli principle are taken into account. The formalism leads one to discuss a new concept, Pauli hindrance, which appears to be important to understand the structure of weakly-bound and unbound systems.Comment: 5 pages, 2 figures, 1 table, contribution to proceedings of "18th International IUPAP Conference on Few-Body Problems in Physics," Santos, Brazil, August 21-26, 200

Irreducible pionic effects in nucleon-deuteron scattering below 20 MeV

The consequences of a recently introduced irreducible pionic effect in low energy nucleon-deuteron scattering are analyzed. Differential cross-sections, nucleon (vector) and deuteron (vector and tensor) analyzing powers, and four different polarization transfer coefficients have been considered. This 3NF-like effect is generated by the pion-exchange diagram in presence of a two-nucleon correlation and is partially cancelled by meson-retardation contributions. Indications are provided that such type of effects are capable to selectively increase the vector (nucleon and deuteron) analyzing powers, while in the considered energy range they are almost negligible on the differential cross sections. These indications, observed with different realistic nucleon-nucleon interactions, provide additional evidences that such 3NF-like effects have indeed the potential to solve the puzzle of the vector analyzing powers. Smaller but non negligible effects are observed for the other spin observables. In some cases, we find that the modifications introduced by such pionic effects on these spin observables (other than the vector analyzing powers) are significant and interesting and could be observed by experiments.Comment: 33 pages, 17 figures, 3 Tables, RevTe

Meson Dynamics and the resulting "3-Nucleon-Force" diagrams: Results from a simplified test case

A simplified 1D (one-dimensional) model for a generalized 3N system is considered, as a testing ground for the explicit treatment of the meson dynamics in this system. We focus attention on the irreducible diagrams generated by the pion dynamics in the 3N system, and in particular to a new type of three-nucleon force discussed recently in the literature, and generated by the one-pion-exchange mechanism in presence of a nucleon-nucleon correlation. It is found that these new terms in the simplified model have an approximately 30% effect compared to the standard three-nucleon force terms in a `Triton' binding energy calculation. It is suggested that this effect should also not be ignored in realistic calculations.Comment: 4 pages, Contribution to "Mesons and Light Nuclei 2001", Prague 2-6, 200

The cosmological 7Li problem from a nuclear physics perspective

The primordial abundance of 7Li as predicted by Big Bang Nucleosynthesis (BBN) is more than a factor 2 larger than what has been observed in metal-poor halo stars. Herein, we analyze the possibility that this discrepancy originates from incorrect assumptions about the nuclear reaction cross sections relevant for BBN. To do this, we introduce an efficient method to calculate the changes in the 7Li abundance produced by arbitrary (temperature dependent) modifications of the nuclear reaction rates. Then, considering that 7Li is mainly produced from 7Be via the electron capture process 7Be + e -> 7Li + nu_e, we assess the impact of the various channels of 7Be destruction. Differently from previous analysis, we consider the role of unknown resonances by using a complete formalism which takes into account the effect of Coulomb and centrifugal barrier penetration and that does not rely on the use of the narrow-resonance approximation. As a result of this, the possibility of a nuclear physics solution to the 7Li problem is significantly suppressed. Given the present experimental and theoretical constraints, it is unlikely that the 7Be + n destruction rate is underestimated by the 2.5 factor required to solve the problem. We exclude, moreover, that resonant destruction in the channels 7Be + t and 7Be + 3He can explain the 7Li puzzle. New unknown resonances in 7Be + d and 7Be + alpha could potentially produce significant effects. Recent experimental results have ruled out such a possibility for 7Be+d. On the other hand, for the 7Be + alpha channel very favorable conditions are required. The possible existence of a partially suitable resonant level in 11C is studied in the framework of a coupled-channel model and the possibility of a direct measurement is considered.Comment: Final version, accepted for publication in JCA

Syndromes lymphoprolifératifs CD19/CD5 positifs: expression différentielle de CD200

Contexte. Le diagnostic différentiel des syndromes lymphoprolifératifs est souvent difficile et nécessite l'intégration de données immunophénotypiques, morphologiques, génétiques et cytogénétiques. La leucémie lymphoïde chronique (LLC) et le lymphome du manteau (LM) sont tous deux des lymphoproliférations CD19 et CD5 positives qu'il est nécessaire de distinguer car le pronostic et le traitement diffèrent. Les analyses génétiques jouent un rôle majeur notamment par la présence de la translocation t(11 ;14) (q13 ;q32) et le réarrangement IgH/CCND1 permettant d'identifier la plupart des lymphomes du manteau. Malgré cela, certains cas atypiques restent difficilement classifiables. CD200 (OX-2), une glycoprotéine transmembranaire jouant un rôle dans l'immunité anti- tumorale pourrait être un marqueur immunophénotypique permettant de distinguer la LLC dans laquelle elle serait surexprimée, du lymphome du manteau dans lequel elle semble déficiente. D'autres syndromes lymphoprolifératifs (SLP) pourraient également bénéficier de ce marqueur. Objectifs. Le but de ce travail est de déterminer si l'analyse de l'expression du CD200 permet de distinguer le lymphome du manteau de la LLC mais également sa corrélation avec d'autres SLP. Méthodes. Analyse de données immunophénotypiques par cytométrie de flux à partir d'une base de données de 68 patients comprenant 44 LLC, 4 lymphomes du manteau, 10 lymphomes folliculaires, 7 lymphomes de la zone marginale, 2 lymphomes lymphoplasmocytaires et une leucémie à tricholeucocytes sur une période allant de novembre 2012 à septembre 2013. L'étude de rapports morphologiques en pathologie, génétique et cytogénétique ainsi qu'une recherche de littérature principalement dans Medline (Pubmed) complète ce travail. Résultats. Ce travail démontre que la coexpression des marqueurs CD19 et CD5 (généralement observée dans la LLC, d'un peu plus faible intensité dans le lymphome du manteau et de très faible intensité dans d'autres lymphomes) n'est pas suffisante pour les distinguer les uns des autres. La coexpression CD200/CD19 forte dans la LLC la distingue du lymphome du manteau avec l'exception de certains cas atypiques de lymphome du manteau. Le ratio CD19/CD200 / CD19/CD5 distingue tous les LLC des lymphomes du manteau mais pas dans tous les cas d'autres SLP, d'autres marqueurs de surface permettant la distinction (CD19/CD10 dans le cas des lymphomes folliculaires et CD19/IgM de surface exprimée avec une forte intensité pour les lymphomes lymphoplasmocytaires). Enfin, la coexpression CD19/CD23 ne permet pas de distinguer tous les cas de LLC de ceux du lymphome du manteau en raison de cas atypiques de LLC. Conclusion. Les observations décrites dans ce travail indiquent que l'addition du marqueur CD200 au panel classique des syndromes lymphoprolifératifs comprenant les marqueurs CD19, CD20, CD23, CD43, CD10, CD5, CD103, CD38 et l'IgM de surface, est utile au diagnostic des lymphomes/leucémies de faible degré de malignité. Toutefois cette analyse doit tenir compte également des divers ratios décrits dans ce travail pour en distinguer avec plus d'efficacité les différents sous-types et permettre d'apporter, avec les résultats de la morphologie, de la cytogénétique, des analyses moléculaires, du séquençage et du profil d'expression génique, les éléments essentiels à une approche diagnostique intégrative. Les résultats sont à considérer avec prudence vu le faible échantillon de patients (n=68)