The risk of multiple anthropogenic and climate change threats must be considered for continental scale conservation and management of seagrass habitat

Globally marine-terrestrial interfaces are highly impacted due to a range of human pressures. Seagrass habitats exist in the shallow marine waters of this interface, have significant values and are impacted by a range of pressures. Cumulative risk analysis is widely used to identify risk from multiple threats and assist in prioritizing management actions. This study conducted a cumulative risk analysis of seagrass habitat associated with the Australian continent to support management actions. We developed a spatially explicit risk model based on a database of threats to coastal aquatic habitat in Australia, spanning 35,000 km of coastline. Risk hotspots were identified using the model and reducing the risk of nutrient and sediment pollution for seagrass habitat was assessed. Incorporating future threats greatly altered the spatial-distribution of risk. High risk from multiple current threats was identified throughout all bioregions, but high risk from climate change alone manifested in only two. Improving management of nutrient and sediment loads, a common approach to conserve seagrass habitat did reduce risk, but only in temperate regions, highlighting the danger of focusing management on a single strategy. Monitoring, management and conservation actions from a national and regional perspective can be guided by these outputs

Proper Motions of the Jets in the Region of HH 30 and HL/XZ Tau. Evidence for a Binary Exciting Source of the HH 30 Jet

We present [SII] images of the HH 30 and HL/XZ Tau region obtained at two epochs, as well as long-slit optical spectroscopy of the HH 30 jet. We measured proper motions of about 100-300 km/s for the HH 30 jet and counterjet, and of about 120 km/s for the HL Tau jet. Inclination angles with respect to the plane of the sky are 0-40 deg for the HH 30 jet and 60 deg for the HL Tau jet. Comparison with previous observations suggests that most of the jet knots consist of persisting structures. Also, we corroborate that the HH 30-N knots correspond to the head of the HH 30 jet. The overall HH 30 jet structure can be well described by a wiggling ballistic jet, arising either by the orbital motion of the jet source around a primary or by precession of the jet axis because of the tidal effects of a companion. In the first scenario, the orbital period would be 53 yr and the total mass 0.25-2 solar masses. In the precession scenario, the mass of the jet source would be 0.1-1 solar masses, the orbital period <1 yr, and the mass of the companion less than a few times 0.01 solar masses, thus being a substellar object or a giant exoplanet. In both scenarios a binary system with a separation <18 AU (<0.13 arcsec) is required. Since the radius of the flared disk observed with the HST is about 250 AU, we conclude that this disk appears to be circumbinary rather than circumstellar, suggesting that the search for the collimating agent of the HH 30 jet should be carried out at much smaller scales.Comment: 42 pages, 7 figures, 5 tables. To Appear in The Astronomical Journal, Vol. 133 No. 6 (June 2007

Results of the JET real-time disruption predictor in the ITER-like wall campaigns

The impact of disruptions in JET became even more important with the replacement of the previous Carbon Fiber Composite (CFC) wall with a more fragile full metal ITER-like wall (ILW). The development of robust disruption mitigation systems is crucial for JET (and also for ITER). Moreover, a reliable real-time (RT) disruption predictor is a pre-requisite to any mitigation method. The Advance Predictor Of DISruptions (APODIS) has been installed in the JET Real-Time Data Network (RTDN) for the RT recognition of disruptions. The predictor operates with the new ILW but it has been trained only with discharges belonging to campaigns with the CFC wall. 7 realtime signals are used to characterize the plasma status (disruptive or non-disruptive) at regular intervals of 1 ms. After the first 3 JET ILW campaigns (991 discharges), the success rate of the predictor is 98.36% (alarms are triggered in average 426 ms before the disruptions). The false alarm and missed alarm rates are 0.92% and 1.64%

Intracellular Triggering of Fas Aggregation and Recruitment of Apoptotic Molecules into Fas-enriched Rafts in Selective Tumor Cell Apoptosis

We have discovered a new and specific cell-killing mechanism mediated by the selective uptake of the antitumor drug 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3, Edelfosine) into lipid rafts of tumor cells, followed by its coaggregation with Fas death receptor (also known as APO-1 or CD95) and recruitment of apoptotic molecules into Fas-enriched rafts. Drug sensitivity was dependent on drug uptake and Fas expression, regardless of the presence of other major death receptors, such as tumor necrosis factor (TNF) receptor 1 or TNF-related apoptosis-inducing ligand R2/DR5 in the target cell. Drug microinjection experiments in Fas-deficient and Fas-transfected cells unable to incorporate exogenous ET-18-OCH3 demonstrated that Fas was intracellularly activated. Partial deletion of the Fas intracellular domain prevented apoptosis. Unlike normal lymphocytes, leukemic T cells incorporated ET-18-OCH3 into rafts coaggregating with Fas and underwent apoptosis. Fas-associated death domain protein, procaspase-8, procaspase-10, c-Jun amino-terminal kinase, and Bid were recruited into rafts, linking Fas and mitochondrial signaling routes. Clustering of rafts was necessary but not sufficient for ET-18-OCH3–mediated cell death, with Fas being required as the apoptosis trigger. ET-18-OCH3–mediated apoptosis did not require sphingomyelinase activation. Normal cells, including human and rat hepatocytes, did not incorporate ET-18-OCH3 and were spared. This mechanism represents the first selective activation of Fas in tumor cells. Our data set a framework for the development of more targeted therapies leading to intracellular Fas activation and recruitment of downstream signaling molecules into Fas-enriched rafts

Implementation of the disruption predictor APODIS in JET Real Time Network using the MARTe framework

Disruptions in tokamaks devices are unavoidable, and they can have a significant impact on machine integrity. So it is very important have mechanisms to predict this phenomenon. Disruption prediction is a very complex task, not only because it is a multi-dimensional problem, but also because in order to be effective, it has to detect well in advance the actual disruptive event, in order to be able to use successful mitigation strategies. With these constraints in mind a real-time disruption predictor has been developed to be used in JET tokamak. The predictor has been designed to run in the Multithreaded Application Real-Time executor (MARTe) framework. The predictor ?Advanced Predictor Of DISruptions? (APODIS) is based on Support Vector Machine (SVM)

Bolsa Família, information and prejudice: an analysis using experiments

Este artigo apresenta e discute os resultados de experimentos de lista e de informação realizados em pesquisas de opinião pública encomendadas pela Secretaria de Comunicação Social da Presidência da República, em 2014 e 2015. Com o experimento de lista, buscava-se captar e estimar um suposto preconceito latente em relação ao Programa Bolsa Família (PBF) e seus beneficiários; e, com os experimentos de informação, avaliar quais mensagens sobre os resultados positivos do programa seriam mais eficientes para mudar opiniões do público em relação a ele e aumentar o seu apoio junto à população brasileira. Até onde sabemos, essas foram umas das poucas vezes em que se utilizaram tais técnicas de pesquisa na elaboração de estratégias de comunicação do Governo Federal. Mas, ao contrário do que se esperava, encontrou-se um apoio latente ao PBF, e não uma rejeição, e as informações repassadas aos entrevistados não foram capazes de alterar suas opiniões.Este artículo presenta y discute los resultados de experimentos de lista y de información realizados en encuestas de opinión pública encargadas por la Secretaría de Comunicación Social de la Presidencia de la República, en 2014 y 2015. Con el experimento de lista, se buscaba captar y estimar un supuesto preconcepto latente en relación al Programa Bolsa Familia (PBF) y sus beneficiarios; y, con los experimentos de información, evaluar qué mensajes sobre los resultados positivos del programa serían más eficientes para cambiar opiniones del público en relación a él y aumentar su apoyo junto a la población brasileña. Hasta donde sabemos, esas fueron unas de las pocas veces en que se utilizaron tales técnicas de investigación en la elaboración de estratégicas de comunicación del Gobierno Federal. Pero, al contrario de lo que se esperaba, se encontró un apoyo latente al PBF, y no un rechazo, y las informaciones repasadas a los entrevistados no fueron capaces de alterar sus opiniones.This article presents and discusses the results of a list and information experiments carried out in public opinion surveys commissioned by the Secretariat of Social Communication of the Presidency of the Republic in 2014 and 2015. The list experiment sought to capture and estimate a supposed latent prejudice in relation to the Bolsa Família Program (PBF) and its beneficiaries. The information experiments sought to evaluate which messages about the positive results of the program would be more efficient to change public opinion about it and to increase its support amongst the Brazilian population. As far as we know, these were one of the few times in which such research techniques were used in the communication strategies elaboration of the Federal Government. However, and contrary to expectations, there was a latent support for the PBF, not a rejection, and the information passed on to interviewees was not able to change their opinions.Revista do Serviço Público - RSP, v. 70, n. 4, p. 551-575Políticas PúblicasISSN Eletrônico: 2357-8017ISSN Impresso: 0034-924

Mass-Loss Rate Determination for the Massive Binary V444 Cyg using 3-D Monte-Carlo Simulations of Line and Polarization Variability

A newly developed 3-D Monte Carlo model is used, in conjunction with a multi-line non-LTE radiative transfer model, to determine the mass-loss rate of the Wolf-Rayet (W-R) star in the massive binary \object{V444 Cyg} (WN5+O6). This independent estimate of mass-loss rate is attained by fitting the observed \HeI (5876) \AA and \HeII (5412) \AA line profiles, and the continuum light curves of three Stokes parameters ((I, Q, U)) in the (V) band simultaneously. The high accuracy of our determination arises from the use of many observational constraints, and the sensitivity of the continuum polarization to the mass-loss rate. Our best fit model suggests that the mass-loss rate of the system is (\dot{M}_{\WR}=0.6(\pm 0.2) \times 10^{-5} M_{\sun} \mathrm{yr}^{-1} ), and is independent of the assumed distance to \object{V444 Cyg}. The fits did not allow a unique value for the radius of the W-R star to be derived. The range of the volume filling factor for the W-R star atmosphere is estimated to be in the range of 0.050 (for R_{\WR}=5.0 R_{\sun}) to 0.075 (for R_{\WR}=2.5 R_{\sun}). We also found that the blue-side of \HeI (5876 ) \AA and \HeII (5412) \AA lines at phase 0.8 is relatively unaffected by the emission from the wind-wind interaction zone and the absorption by the O-star atmosphere; hence, the profiles at this phase are suitable for spectral line fittings using a spherical radiative transfer model.Comment: 18 pages, 17 figures: Accepeted for publication in A&

Endoleak after endovascular repair of abdominal aortic aneurysm

AbstractPurpose: We sought to assess the role of endovascular techniques in the management of perigraft flow (endoleak) after endovascular repair of an abdominal aortic aneurysm. Method: We performed endovascular repair of abdominal aortic aneurysm in 114 patients, using a variety of Gianturco Z-stent–based prostheses. Results were evaluated with contrast-enhanced computed tomography (CT) at 3 days, 3 months, 6 months, 12 months, and every year after the operation. An endoleak that occurred 3 days after operation led to repeat CT scanning at 2 weeks, followed by angiography and attempted endovascular treatment. Results: Endoleak was seen on the first postoperative CT scan in 21 (18%) patients and was still present at 2 weeks in 14 (12%). On the basis of angiographic localization of the inflow, the endoleak was pure type I in 3 cases, pure type II in 9, and mixed-pattern in 2. Of the 5 type I endoleaks, 3 were proximal and 2 were distal. All five resolved after endovascular implantation of additional stent-grafts, stents, and embolization coils. Although inferior mesenteric artery embolization was successful in 6 of 7 cases and lumbar embolization was successful in 4 of 7, only 1 of 11 primary type II endoleaks was shown to be resolved on CT scanning. There were no type III or type IV endoleaks (through the stent-graft). Endoleak was associated with aneurysm dilation two cases. In both cases, the aneurysm diameter stabilized after coil embolization of the inferior mesenteric artery. There were two secondary (delayed) endoleaks; one type I and one type II. The secondary type I endoleak and the associated aneurysm rupture were treated by use of an additional stent-graft. The secondary type II endoleak was not treated. Conclusions: Type I endoleaks represent a persistent risk of aneurysm rupture and should be treated promptly by endovascular means. Type II leaks are less dangerous and more difficult to treat, but coil embolization of feeding arteries may be warranted when leakage is associated with aneurysm enlargement. (J Vasc Surg 2001;34:98-105.

Linkage and related analyses of Barrett's esophagus and its associated adenocarcinomas

BACKGROUND: Familial aggregation and segregation analysis studies have provided evidence of a genetic basis for esophageal adenocarcinoma (EAC) and its premalignant precursor, Barrett's esophagus (BE). We aim to demonstrate the utility of linkage analysis to identify the genomic regions that might contain the genetic variants that predispose individuals to this complex trait (BE and EAC). METHODS: We genotyped 144 individuals in 42 multiplex pedigrees chosen from 1000 singly ascertained BE/EAC pedigrees, and performed both model‐based and model‐free linkage analyses, using S.A.G.E. and other software. Segregation models were fitted, from the data on both the 42 pedigrees and the 1000 pedigrees, to determine parameters for performing model‐based linkage analysis. Model‐based and model‐free linkage analyses were conducted in two sets of pedigrees: the 42 pedigrees and a subset of 18 pedigrees with female affected members that are expected to be more genetically homogeneous. Genome‐wide associations were also tested in these families. RESULTS: Linkage analyses on the 42 pedigrees identified several regions consistently suggestive of linkage by different linkage analysis methods on chromosomes 2q31, 12q23, and 4p14. A linkage on 15q26 is the only consistent linkage region identified in the 18 female‐affected pedigrees, in which the linkage signal is higher than in the 42 pedigrees. Other tentative linkage signals are also reported. CONCLUSION: Our linkage study of BE/EAC pedigrees identified linkage regions on chromosomes 2, 4, 12, and 15, with some reported associations located within our linkage peaks. Our linkage results can help prioritize association tests to delineate the genetic determinants underlying susceptibility to BE and EAC