244 research outputs found
Effect of Repeated Loads on the Low Temperature Fracture Behavior of Notched and Welded Plates
The influence of repeated loadings on the susceptibility of weldments
to fracture in a brittle manner is studied for an ABS-Class C steel.
The test members have consisted primarily of 12, 24 and 36 in. wide notched-and-
welded specimens that, at low temperatures, have been known to provide low-stress brittle fractures.
The repeated loads or loading history are found to affect the
fracture behavior of the weldments. In all but one instance the fracture stresses obtained for the notched-and welded wide plates were greater than the stresses to which the members had been subjected during the repeated
loadings. Furthermore, the repeated loadings appeared to eliminate the two-stage fractures observed in some of the tests of as-welded specimens. This latter condition is in general desirable, but only if the fracture stress is raised to a high-stress level.Bureau of Ships - Department of the Navy Contract NObs 88283 Proj ect SR-149 Ship Structure Committe
Spin tunnelling in mesoscopic systems
We study spin tunnelling in molecular magnets as an instance of a mesoscopic
phenomenon, with special emphasis on the molecule Fe8. We show that the tunnel
splitting between various pairs of Zeeman levels in this molecule oscillates as
a function of applied magnetic field, vanishing completely at special points in
the space of magnetic fields, known as diabolical points. This phenomena is
explained in terms of two approaches, one based on spin-coherent-state path
integrals, and the other on a generalization of the phase integral (or WKB)
method to difference equations. Explicit formulas for the diabolical points are
obtained for a model Hamiltonian.Comment: 13 pages, 5 figures, uses Pramana style files; conference proceedings
articl
Elevated circulating and placental SPINT2 is associated with placental dysfunction
Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is a functionally related placental protease inhibitor. This study aimed to characterise SPINT2 expression in placental insufficiency. Circulating SPINT2 was assessed in three prospective cohorts, collected at the following: (1) term delivery (n = 227), (2) 36 weeks (n = 364), and (3) 24–34 weeks’ (n = 294) gestation. SPINT2 was also measured in the plasma and placentas of women with established placental disease at preterm (p = 0.028; median = 2233 pg/mL vs. controls, median = 1644 pg/mL), or delivered a small-for-gestational-age infant (p = 0.002; median = 2109 pg/mL vs. controls, median = 1614 pg/mL). SPINT2 was elevated in the placentas of patients who required delivery for preterm preeclampsia (p = 0.025). Though inflammatory cytokines had no effect, hypoxia increased SPINT2 in cytotrophoblast stem cells, and its expression was elevated in the placental labyrinth of growth-restricted rats. These findings suggest elevated SPINT2 is associated with placental insufficiency
A Measurement of Time-Averaged Aerosol Optical Depth using Air-Showers Observed in Stereo by HiRes
Air fluorescence measurements of cosmic ray energy must be corrected for
attenuation of the atmosphere. In this paper we show that the air-showers
themselves can yield a measurement of the aerosol attenuation in terms of
optical depth, time-averaged over extended periods. Although the technique
lacks statistical power to make the critical hourly measurements that only
specialized active instruments can achieve, we note the technique does not
depend on absolute calibration of the detector hardware, and requires no
additional equipment beyond the fluorescence detectors that observe the air
showers. This paper describes the technique, and presents results based on
analysis of 1258 air-showers observed in stereo by the High Resolution Fly's
Eye over a four year span.Comment: 7 pages, 3 figures, accepted for publication by Astroparticle Physics
Journa
Young and Intermediate-age Distance Indicators
Distance measurements beyond geometrical and semi-geometrical methods, rely
mainly on standard candles. As the name suggests, these objects have known
luminosities by virtue of their intrinsic proprieties and play a major role in
our understanding of modern cosmology. The main caveats associated with
standard candles are their absolute calibration, contamination of the sample
from other sources and systematic uncertainties. The absolute calibration
mainly depends on their chemical composition and age. To understand the impact
of these effects on the distance scale, it is essential to develop methods
based on different sample of standard candles. Here we review the fundamental
properties of young and intermediate-age distance indicators such as Cepheids,
Mira variables and Red Clump stars and the recent developments in their
application as distance indicators.Comment: Review article, 63 pages (28 figures), Accepted for publication in
Space Science Reviews (Chapter 3 of a special collection resulting from the
May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space
Age
A practical drug discovery project at the undergraduate level
A practical drug discovery project for third-year undergraduates is described. No previous knowledge of medicinal chemistry is assumed. Initial lecture-workshops cover the basic principles; then students are asked to improve the profile of a weakly potent, poorly soluble PI3K inhibitor (1). Compound array design, molecular modelling and screening data analysis are followed by laboratory work in which each student, as part of a team, attempts to synthesise at least two target compounds. The project benefits from significant industrial support, including lectures, student mentoring and consumables. The aim is to make the learning experience as close as possible to real-life industrial situations. Forty-eight target compounds have been prepared, the best of which (5b, 5j, 6b and 6ap) improved the potency and aqueous solubility of the lead compound (1) by 100-1000 fold and 10-fold, respectively
Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy
We review HB stars in a broad astrophysical context, including both variable
and non-variable stars. A reassessment of the Oosterhoff dichotomy is
presented, which provides unprecedented detail regarding its origin and
systematics. We show that the Oosterhoff dichotomy and the distribution of
globular clusters (GCs) in the HB morphology-metallicity plane both exclude,
with high statistical significance, the possibility that the Galactic halo may
have formed from the accretion of dwarf galaxies resembling present-day Milky
Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the
second-parameter problem is presented. A technique is proposed to estimate the
HB types of extragalactic GCs on the basis of integrated far-UV photometry. The
relationship between the absolute V magnitude of the HB at the RR Lyrae level
and metallicity, as obtained on the basis of trigonometric parallax
measurements for the star RR Lyrae, is also revisited, giving a distance
modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are
studied. Finally, the conductive opacities used in evolutionary calculations of
low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and
Space Scienc
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