13,027 research outputs found

    ‘Hearts and minds’: association, causation and implication of cognitive impairment in heart failure

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    The clinical syndrome of heart failure is one of the leading causes of hospitalisation and mortality in older adults. An association between cognitive impairment and heart failure is well described but our understanding of the relationship between the two conditions remains limited. In this review we provide a synthesis of available evidence, focussing on epidemiology, the potential pathogenesis, and treatment implications of cognitive decline in heart failure. Most evidence available relates to heart failure with reduced ejection fraction and the syndromes of chronic cognitive decline or dementia. These conditions are only part of a complex heart failure-cognition paradigm. Associations between cognition and heart failure with preserved ejection fraction and between acute delirium and heart failure also seem evident and where data are available we will discuss these syndromes. Many questions remain unanswered regarding heart failure and cognition. Much of the observational evidence on the association is confounded by study design, comorbidity and insensitive cognitive assessment tools. If a causal link exists, there are several potential pathophysiological explanations. Plausible underlying mechanisms relating to cerebral hypoperfusion or occult cerebrovascular disease have been described and it seems likely that these may coexist and exert synergistic effects. Despite the prevalence of the two conditions, when cognitive impairment coexists with heart failure there is no specific guidance on treatment. Institution of evidence-based heart failure therapies that reduce mortality and hospitalisations seems intuitive and there is no signal that these interventions have an adverse effect on cognition. However, cognitive impairment will present a further barrier to the often complex medication self-management that is required in contemporary heart failure treatment

    The Algebra of Strand Splitting. I. A Braided Version of Thompson's Group V

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    We construct a braided version of Thompson's group V.Comment: 27 page

    Fixation of virgin lunar surface soil

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    Two systems are shown to be suitable for fixing loose particulate soils with a polymer film, without visually detectable disturbance of the soil particle spatial relationships. A two-component system is described, which uses a gas monomer condensible at the soil temperature and a gas phase catalyst acting to polymerize the monomer. A one-component system using a monomer which polymerizes spontaneously on and within the top few millimeters of the soil is also considered. The two-component system employs a simpler apparatus, but it operates over a narrower temperature range (approximately -40 to -10 C). Other two-component systems were identified which may operate at soil temperatures as high as +100 C, at relatively narrow temperature ranges of approximately 30 C. The one-component system was demonstrated to operate successfully with initial soil temperatures from -70 C or lower to +150 C

    A Unified Near Infrared Spectral Classification Scheme for T Dwarfs

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    A revised near infrared classification scheme for T dwarfs is presented, based on and superseding prior schemes developed by Burgasser et al. and Geballe et al., and defined following the precepts of the MK Process. Drawing from two large spectroscopic libraries of T dwarfs identified largely in the Sloan Digital Sky Survey and the Two Micron All Sky Survey, nine primary spectral standards and five alternate standards spanning spectral types T0 to T8 are identified that match criteria of spectral character, brightness, absence of a resolved companion and accessibility from both northern and southern hemispheres. The classification of T dwarfs is formally made by the direct comparison of near infrared spectral data of equivalent resolution to the spectra of these standards. Alternately, we have redefined five key spectral indices measuring the strengths of the major H2_2O and CH4_4 bands in the 1-2.5 micron region that may be used as a proxy to direct spectral comparison. Two methods of determining T spectral type using these indices are outlined and yield equivalent results. These classifications are also equivalent to those from prior schemes, implying that no revision of existing spectral type trends is required. The one-dimensional scheme presented here provides a first step toward the observational characterization of the lowest luminosity brown dwarfs currently known. Future extensions to incorporate spectral variations arising from differences in photospheric dust content, gravity and metallicity are briefly discussed. A compendium of all currently known T dwarfs with updated classifications is presented.Comment: 52 pages, 11 figures; accepted for publication to Ap

    Invariant Peano curves of expanding Thurston maps

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    We consider Thurston maps, i.e., branched covering maps f ⁣:S2→S2f\colon S^2\to S^2 that are postcritically finite. In addition, we assume that ff is expanding in a suitable sense. It is shown that each sufficiently high iterate F=fnF=f^n of ff is semi-conjugate to zd ⁣:S1→S1z^d\colon S^1\to S^1, where dd is equal to the degree of FF. More precisely, for such an FF we construct a Peano curve γ ⁣:S1→S2\gamma\colon S^1\to S^2 (onto), such that F∘γ(z)=γ(zd)F\circ \gamma(z) = \gamma(z^d) (for all z∈S1z\in S^1).Comment: 63 pages, 12 figure

    Phase Diagram of One-Dimensional Extended Hubbard Model at Half Filling

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    We reexamine the ground-state phase diagram of the one-dimensional half-filled Hubbard model with on-site and nearest-neighbor repulsive interactions. We calculate second-order corrections to coupling constants in the g-ology to show that the bond-charge-density-wave (BCDW) phase exists for weak couplings in between the charge density wave (CDW) and spin density wave (SDW) phases. We find that the umklapp scattering of parallel-spin electrons destabilizes the BCDW state and gives rise to a bicritical point where the CDW-BCDW and SDW-BCDW continuous-transition lines merge into the CDW-SDW first-order transition line.Comment: 4 pages, 3 figure

    Scalable Task-Based Algorithm for Multiplication of Block-Rank-Sparse Matrices

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    A task-based formulation of Scalable Universal Matrix Multiplication Algorithm (SUMMA), a popular algorithm for matrix multiplication (MM), is applied to the multiplication of hierarchy-free, rank-structured matrices that appear in the domain of quantum chemistry (QC). The novel features of our formulation are: (1) concurrent scheduling of multiple SUMMA iterations, and (2) fine-grained task-based composition. These features make it tolerant of the load imbalance due to the irregular matrix structure and eliminate all artifactual sources of global synchronization.Scalability of iterative computation of square-root inverse of block-rank-sparse QC matrices is demonstrated; for full-rank (dense) matrices the performance of our SUMMA formulation usually exceeds that of the state-of-the-art dense MM implementations (ScaLAPACK and Cyclops Tensor Framework).Comment: 8 pages, 6 figures, accepted to IA3 2015. arXiv admin note: text overlap with arXiv:1504.0504

    MUSE Illuminates Channels for Lyman Continuum Escape in the Halo of SBS 0335-52E

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    We report on the discovery of ionised gas filaments in the circum-galactic halo of the extremely metal-poor compact starburst SBS 0335-052E in a 1.5h integration with the MUSE integral-field spectrograph. We detect these features in Hα{\alpha} and [OIII] emission down to surface-brightness levels of 5×10−195 \times 10^{-19}erg s−1^{-1}cm−2^{-2}arcsec−2^{-2}. The filaments have projected diameters of 2.1 kpc and extend more than 9 kpc to the north and north-west from the main stellar body. We also detect extended nebular HeII λ\lambda4686 emission that brightens towards the north-west at the rim of a star-burst driven super-shell, suggestive of a locally enhanced UV radiation field due to shocks. We also present a velocity field of the ionised gas. The filaments appear to connect seamlessly in velocity space to the kinematical disturbances caused by the shell. Similar to high-zz star-forming galaxies, the ionised gas in this galaxy is dispersion dominated. We argue that the filaments were created via feedback from the starburst and that these ionised structures in the halo may act as escape channels for Lyman continuum radiation in this gas-rich system.Comment: Revised version after peer review. Accepted for publication in A&A letter
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