Use of a Distal Radius Endoprosthesis Following Resection of a Bone Tumour: A Case Report

Limited literature is available on the reconstruction of the distal radius using prosthetic replacement following resection of a bone tumour. We present the first reported case, in the English literature, of the use of an entirely metal endoprosthesis for the reconstruction of the distal radius. This case involves a 66-year-old male who was treated for giant cell tumour of the distal radius with surgical excision of the lesion and replacement of the defect using a predominantly titanium endoprosthesis. He was followed-up for 56 months following surgery and had a good functional outcome with no associated pain or complications. We propose that the use of a primarily titanium endoprosthesis for the reconstruction of a bone defect of the distal radius is a suitable alternative, providing good function of the forearm with satisfactory range of movement at the wrist and adequate pain relief

Post-radiation sciatic neuropathy: a case report and review of the literature

<p>Abstract</p> <p>Background</p> <p>Post-radiation peripheral neuropathy has been reported in brachial and cervical plexuses and the femoral nerve.</p> <p>Case presentation</p> <p>We describe a patient who developed post-radiation sciatic neuropathy after approximately 3 years and discuss the pathophysiology, clinical course and treatment options available for the deleterious effects of radiation to peripheral nerves.</p> <p>Conclusion</p> <p>This is the first case of post-radiation involvement of the sciatic nerve reported in the literature.</p

"Pseudosarcoma" in a pregnant woman

BACKGROUND: Intravascular fasciitis (IVF) is a rare benign condition characterised by reactive myofibroblastic proliferation arising from the superficial or deep fascia and involving arteries and/or veins. It is a distinct variant of the more common condition of nodular fasciitis, which possesses similar clinical and histological features to IVF, but lacks vascular invasion. A thorough review of the literature revealed 26 reported cases of IVF. CASE PRESENTATION: We report a case of IVF in a 16-week pregnant lady affecting the hypothenar eminence of the hand associated with the ulnar artery. CONCLUSION: The characteristic involvement of muscular arteries and veins by reactive myofibroblastic proliferation in IVF suggests a malignant component and often leads to an inappropriate diagnosis for this benign condition. We propose that hormone-related changes associated with pregnancy may play an important role in the aetiopathogenesis of this myofibroblastic lesion

Galaxy groups in the 2dFGRS: the group-finding algorithm and the 2PIGG catalogue

The construction of a catalogue of galaxy groups from the Two-degree Field Galaxy Redshift Survey (2dFGRS) is described. Groups are identified by means of a friends-of-friends percolation algorithm which has been thoroughly tested on mock versions of the 2dFGRS generated from cosmological N-body simulations. The tests suggest that the algorithm groups all galaxies that it should be grouping, with an additional 40 per cent of interlopers. About 55 per cent of the ∼190 000 galaxies considered are placed into groups containing at least two members of which ∼29 000 are found. Of these, ∼7000 contain at least four galaxies, and these groups have a median redshift of 0.11 and a median velocity dispersion of 260 km s−1. This 2dFGRS Percolation-Inferred Galaxy Group (2PIGG) catalogue represents the largest available homogeneous sample of galaxy groups. It is publicly available on the World Wide We

The 2dF Galaxy Redshift Survey: power-spectrum analysis of the final data set and cosmological implications

We present a power-spectrum analysis of the final 2dF Galaxy Redshift Survey (2dFGRS), employing a direct Fourier method. The sample used comprises 221 414 galaxies with measured redshifts. We investigate in detail the modelling of the sample selection, improving on previous treatments in a number of respects. A new angular mask is derived, based on revisions to the photometric calibration. The redshift selection function is determined by dividing the survey according to rest-frame colour, and deducing a self-consistent treatment of k-corrections and evolution for each population. The covariance matrix for the power-spectrum estimates is determined using two different approaches to the construction of mock surveys, which are used to demonstrate that the input cosmological model can be correctly recovered. We discuss in detail the possible differences between the galaxy and mass power spectra, and treat these using simulations, analytic models and a hybrid empirical approach. Based on these investigations, we are confident that the 2dFGRS power spectrum can be used to infer the matter content of the universe. On large scales, our estimated power spectrum shows evidence for the ‘baryon oscillations' that are predicted in cold dark matter (CDM) models. Fitting to a CDM model, assuming a primordial ns= 1 spectrum, h= 0.72 and negligible neutrino mass, the preferred parameters are Ωmh= 0.168 ± 0.016 and a baryon fraction Ωb/Ωm= 0.185 ± 0.046 (1σ errors). The value of Ωmh is 1σ lower than the 0.20 ± 0.03 in our 2001 analysis of the partially complete 2dFGRS. This shift is largely due to the signal from the newly sampled regions of space, rather than the refinements in the treatment of observational selection. This analysis therefore implies a density significantly below the standard Ωm= 0.3: in combination with cosmic microwave background (CMB) data from the Wilkinson Microwave Anisotropy Probe (WMAP), we infer Ωm= 0.231 ± 0.02

Galaxy groups in the Two-degree Field Galaxy Redshift Survey: the luminous content of the groups

The Two-degree Field Galaxy Redshift Survey (2dFGRS) Percolation-Inferred Galaxy Group (2PIGG) catalogue of ∼29 000 objects is used to study the luminous content of galaxy systems of various sizes. Mock galaxy catalogues constructed from cosmological simulations are used to gauge the accuracy with which intrinsic group properties can be recovered. It is found that a Schechter function is a reasonable fit to the galaxy luminosity functions in groups of different mass in the real data, and that the characteristic luminosity L⋆ is slightly larger for more massive groups. However, the mock data show that the shape of the recovered luminosity function is expected to differ from the true shape, and this must be allowed for when interpreting the data. Luminosity function results are presented in both the bJ and rF wavebands. The variation of the halo mass-to-light ratio, ϒ, with group size is studied in both of these wavebands. A robust trend of increasing ϒ with increasing group luminosity is found in the 2PIGG data. Going from groups with bJ luminosities equal to 1010h−2 L⊙ to those 100 times more luminous, the typical bJ-band mass-to-light ratio increases by a factor of 5, whereas the rF-band mass-to-light ratio grows by a factor of 3.5. These trends agree well with the predictions of the simulations which also predict a minimum in the mass-to-light ratio on a scale roughly corresponding to the Local Group. The data indicate that if such a minimum exists, then it must occur at L≲ 1010h−2 L⊙, below the range accurately probed by the 2PIGG catalogue. According to the mock data, the bJ mass-to-light ratios of the largest groups are expected to be approximately 1.1 times the global value. Assuming that this correction applies to the real data, the mean bJ luminosity density of the Universe yields an estimate of Ωm= 0.26 ± 0.03 (statistical error only). Various possible sources of systematic error are considered, with the conclusion that these could affect the estimate of Ωm by a few tens of per cen

The 2dF Galaxy Redshift Survey: the clustering of galaxy groups

We measure the clustering of galaxy groups in the 2dFGRS Percolation-Inferred Galaxy Group (2PIGG) catalogue. The 2PIGG sample has 28 877 groups with at least two members. The clustering amplitude of the full 2PIGG catalogue is weaker than that of 2dFGRS galaxies, in agreement with theoretical predictions. We have subdivided the 2PIGG catalogue into samples that span a factor of ≈ 25 in median total luminosity. Our correlation function measurements span an unprecedented range of clustering strengths, connecting the regimes probed by groups fainter than L* galaxies and rich clusters. There is a steady increase in clustering strength with group luminosity; the most luminous groups are 10 times more strongly clustered than the full 2PIGG catalogue. We demonstrate that the 2PIGG results are in very good agreement with the clustering of groups expected in the ΛCDM mode

A Novel Soluble Immune-Type Receptor (SITR) in Teleost Fish: Carp SITR Is Involved in the Nitric Oxide-Mediated Response to a Protozoan Parasite

Background- The innate immune system relies upon a wide range of germ-line encoded receptors including a large number of immunoglobulin superfamily (IgSF) receptors. Different Ig-like immune receptor families have been reported in mammals, birds, amphibians and fish. Most innate immune receptors of the IgSF are type I transmembrane proteins containing one or more extracellular Ig-like domains and their regulation of effector functions is mediated intracellularly by distinct stimulatory or inhibitory pathways. Methodology/Principal Findings - Carp SITR was found in a substracted cDNA repertoire from carp macrophages, enriched for genes up-regulated in response to the protozoan parasite Trypanoplasma borreli. Carp SITR is a type I protein with two extracellular Ig domains in a unique organisation of a N-proximal V/C2 (or I-) type and a C-proximal V-type Ig domain, devoid of a transmembrane domain or any intracytoplasmic signalling motif. The carp SITR C-proximal V-type Ig domain, in particular, has a close sequence similarity and conserved structural characteristics to the mammalian CD300 molecules. By generating an anti-SITR antibody we could show that SITR protein expression was restricted to cells of the myeloid lineage. Carp SITR is abundantly expressed in macrophages and is secreted upon in vitro stimulation with the protozoan parasite T. borreli. Secretion of SITR protein during in vivo T. borreli infection suggests a role for this IgSF receptor in the host response to this protozoan parasite. Overexpression of carp SITR in mouse macrophages and knock-down of SITR protein expression in carp macrophages, using morpholino antisense technology, provided evidence for the involvement of carp SITR in the parasite-induced NO production. Conclusion/Significance - We report the structural and functional characterization of a novel soluble immune-type receptor (SITR) in a teleost fish and propose a role for carp SITR in the NO-mediated response to a protozoan parasite

Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG

BACKGROUND In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite‐based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members. METHODS In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome‐wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups. RESULTS Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37 cM interval on 4q13–25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD scores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC , an important gene in PC biology. CONCLUSIONS These results will be useful in prioritizing future susceptibility gene discovery efforts in this common cancer. Prostate 72:410–426, 2012. © 2011 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90245/1/21443_ftp.pd