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research
Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG
Authors
Michael D. Badzioch
Joan E. Bailey‐wilson
+56 more
Nicola J. Camp
Geraldine Cancel‐tassin
Lisa A. Cannon‐albright
John D. Carpten
William J. Catalona
Kathleen A. Cooney
Cheryl D. Cropp
Olivier Cussenot
Kerry Deutsch
Douglas Easton
Steve Edwards
Ros Eeles
Monica Emanuelsson
Dallas R. English
James M. Farnham
Liesel M. FitzGerald
William D. Foulkes
Graham G. Giles
Henrik Grönberg
Michelle Guy
Scott Hebbring
Brian T. Helfand
Kathleen Herkommer
Josef Hoegel
John L. Hopper
Chih-Lin Hsieh
Sarah D. Isaacs
William B. Isaacs
Bo Johanneson
Donghui Kan
Ethan M. Lange
Lingyi Lu
Lovise Maehle
Christiane Maier
Shannon K. McDonnell
Laura McIntosh
Pal Moller
Ingrid Oakley‐girvan
Elaine A. Ostrander
Isaac Powell
Daniel J. Schaid
Johanna Schleutker
Daniela Seminara
Gianluca Severi
Claire Simpson
Janet L. Stanford
Teuvo L. J. Tammela
Stephen N. Thibodeau
Antoine Valeri
Walther Vogel
Patrick C. Walsh
Alice S. Whittemore
Fredrik Wiklund
Kathleen E. Wiley
Jianfen Xu
S. Lilly Zheng
Publication date
1 March 2012
Publisher
'Wiley'
Doi
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on
PubMed
Abstract
BACKGROUND In spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite‐based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members. METHODS In an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome‐wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups. RESULTS Of the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37 cM interval on 4q13–25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD scores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC , an important gene in PC biology. CONCLUSIONS These results will be useful in prioritizing future susceptibility gene discovery efforts in this common cancer. Prostate 72:410–426, 2012. © 2011 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90245/1/21443_ftp.pd
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info:doi/10.1002%2Fpros.21443
Last time updated on 03/12/2019
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Last time updated on 25/05/2012