The mass and dynamical state of Abell 2218

Abell 2218 is one of a handful of clusters in which X-ray and lensing analyses of the cluster mass are in strong disagreement. It is also a system for which X-ray data and radio measurements of the Sunyaev-Zel'dovich decrement have been combined in an attempt to constrain the Hubble constant. However, in the absence of reliable information on the temperature structure of the intracluster gas, most analyses have been carried out under the assumption of isothermality. We combine X-ray data from the ROSAT PSPC and the ASCA GIS instruments, enabling us to fit non-isothermal models, and investigate the impact that this has on the X-ray derived mass and the predicted Sunyaev-Zel'dovich effect. We find that a strongly non-isothermal model for the intracluster gas, which implies a central cusp in the cluster mass distribution, is consistent with the available X-ray data and compatible with the lensing results. At r<1 arcmin, there is strong evidence to suggest that the cluster departs from a simple relaxed model. We analyse the dynamics of the galaxies and find that the central galaxy velocity dispersion is too high to allow a physical solution for the galaxy orbits. The quality of the radio and X-ray data do not at present allow very restrictive constraints to be placed on H_0. It is apparent that earlier analyses have under-estimated the uncertainties involved. However, values greater than 50 km/s/Mpc are preferred when lensing constraints are taken into account.Comment: 16 pages, 9 postscript figures, accepted for publication in MNRA

On the engineering portion of a research program - To perform a gyro test of general relativity in a satellite and develop associated control technology

Satellite attitude control using gyro-telescope structure driven by superconducting actuato

Lesions mimicking lacrimal gland pleomorphic adenoma

Aim: To report a series of patients with lacrimal gland lesions simulating the clinicoradiological features of lacrimal gland pleomorphic adenoma (LGPA). Methods: Multicentre retrospective, interventional case series. Clinical records of all patients with lesions mimicking LGPA seen in five orbital units were reviewed. Results: The study included 14 patients (seven men and seven women) with a mean age of 50.9 years. The diagnosis of LGPA was made in all cases by experienced orbital surgeons, based on clinicoradiological features, and lacrimal gland excision was performed. Postoperative histology revealed lymphoma (four patients), chronic dacryoadenitis (three patients), adenoid cystic carcinoma (two patients), Sjogren's syndrome (two patients), cavernous haemangioma (one patient), benign lymphoid hyperplasia (one patient) and granulomatous dacryoadenitis (one patient). Comparison with the total number of histologically confirmed LGPA cases seen during the study period revealed that 22.6% of cases of suspected LGPA were misdiagnosed based on clinicoradiological criteria. Conclusions: Many different lesions may mimic the clinicoradiological features of LGPA. The accepted clinicoradiological criteria used for the diagnosis of LGPA have a high false-positive rate, even in experienced hands. Based on this study, the authors believe that fine-needle aspiration biopsy or intraoperative biopsy and frozen section diagnosis may help reduce unnecessary lacrimal gland excision.Venkatesh C Prabhakaran, Paul S Cannon, Alan McNab, Garry Davis, Brett O’Donnell, Peter J Dolman, Raf Ghabrial, Dinesh Selv

J-type Carbon Stars in the Large Magellanic Cloud

A sample of 1497 carbon stars in the Large Magellanic Cloud has been observed in the red part of the spectrum with the 2dF facility on the AAT. Of these, 156 have been identified as J-type (i.e. 13C-rich) carbon stars using a technique which provides a clear distinction between J stars and the normal N-type carbon stars that comprise the bulk of the sample, and yields few borderline cases. A simple 2-D classification of the spectra, based on their spectral slopes in different wavelength regions, has been constructed and found to be related to the more conventional c- and j-indices, modified to suit the spectral regions observed. Most of the J stars form a photometric sequence in the K - (J-K) colour magnitude diagram, parallel to and 0.6 mag fainter than the N star sequence. A subset of the J stars (about 13 per cent) are brighter than this J star sequence; most of these are spectroscopically different from the other J stars. The bright J stars have stronger CN bands than the other J stars and are found strongly concentrated in the central regions of the LMC. Most of the rather few stars in common with Hartwick and Cowley's sample of suspected CH stars are J stars. Overall, the proportion of carbon stars identified as J stars is somewhat lower than has been found in the Galaxy. The Na D lines are weaker in the LMC J stars than in either the Galactic J stars or the LMC N stars, and do not seem to depend on temperature.Comment: 19 pages, 21 figures, Latex; in press, MNRA

Mechanism of CDW-SDW Transition in One Dimension

The phase transition between charge- and spin-density-wave (CDW, SDW) phases is studied in the one-dimensional extended Hubbard model at half-filling. We discuss whether the transition can be described by the Gaussian and the spin-gap transitions under charge-spin separation, or by a direct CDW-SDW transition. We determine these phase boundaries by level crossings of excitation spectra which are identified according to discrete symmetries of wave functions. We conclude that the Gaussian and the spin-gap transitions take place separately from weak- to intermediate-coupling region. This means that the third phase exists between the CDW and the SDW states. Our results are also consistent with those of the strong-coupling perturbative expansion and of the direct evaluation of order parameters.Comment: 5 pages(REVTeX), 5 figures(EPS), 1 table, also available from http://wwwsoc.nacsis.ac.jp/jps/jpsj/1999/p68a/p68a42/p68a42h/p68a42h.htm

DiagHunter and GenoPix2D: programs for genomic comparisons, large-scale homology discovery and visualization

The DiagHunter and GenoPix2D applications work together to enable genomic comparisons and exploration at both genome-wide and single-gene scales. DiagHunter identifies homologous regions (synteny blocks) within or between genomes. DiagHunter works efficiently with diverse, large datasets to predict extended and interrupted synteny blocks and to generate graphical and text output quickly. GenoPix2D allows interactive display of synteny blocks and other genomic features, as well as querying by annotation and by sequence similarity

Nine years of comparative effectiveness research education and training: initiative supported by the PhRMA Foundation

The term comparative effectiveness research (CER) took center stage with passage of the American Recovery and Reinvestment Act (2009). The companion US$1.1 billion in funding prompted the launch of initiatives to train the scientific workforce capable of conducting and using CER. Passage of the Patient Protection and Affordable Care Act (2010) focused these initiatives on patients, coining the term ‘patient-centered outcomes research’ (PCOR). Educational and training initiatives were soon launched. This report describes the initiative of the Pharmaceutical Research and Manufacturers Association of America (PhRMA) Foundation. Through provision of grant funding to six academic Centers of Excellence, to spearheading and sponsoring three national conferences, the PhRMA Foundation has made significant contributions to creation of the scientific workforce that conducts and uses CER/PCOR