Analisi esplorativa della statuina neolitica di Vicofertile

La statuina neolitica femminile rinvenuta in una sepoltura a Vicofertile risulta prodotta localmente (analoga per composizione alle altre ceramiche dell'area parmense) e plasmata in tre parti successivamente assemblat

Relationship between COVID-19 Mortality, Hospital Beds, and Primary Care by Italian Regions: A Lesson for the Future

One of the characteristics of the SARS-CoV-2 infection in Italy is the significant regional difference in terms of lethality and mortality. These geographical variances were clear in the first wave and confirmed in the second one as well. The study aimed to analyze the correlation between regional differences in COVID-19 mortality and different regional care models, by retrospectively analyzing the association between the Italian COVID-19 deaths and the number of hospital beds, long-term care facilities, general practitioners (GPs), and the health expenditure per capita. The period considered was from 1 March 2020 to 1 March 2021. The number of hospital beds (p < 0.0001) and the number of GPs (p = 0.0094) significantly predicted the COVID-19 death rate. The Italian regions with a higher number of hospital beds and a lower number of GPs showed a higher number of deaths. Multivariate analyses confirmed the results. The Italian regions with a higher amount of centralized healthcare, as represented by the number of hospital beds, experienced a higher number of deaths, while the regions with greater community support, as exemplified by the number of the GPs, faced higher survival. These results suggest the need for a change in the current healthcare system organization

Towards a monitoring system of the sea state based on microseism and machine learning

In this work, we exploited the ubiquitous seismic noise generated by energy transfer from the sea to the solid Earth (called microseism) to infer the significant wave height data, with the aim of developing a microseism-based monitoring system of the Sicily Channel. We used a combined approach based on statistical analysis and machine learning by using seismic and sea state data (provided by the hindcast maps), recorded between 2018 and 2021.Through spectral and amplitude analysis, we observed that microseism was influenced by the conditions of the seas surrounding Sicily. Correlation analysis demonstrates that microseism mostly originates from sources located up to 400 km from the coastlines. Moreover, employing machine learning algorithms, we successfully reconstruct spatial and temporal sea wave distributions using microseism data. Among the tested methods, the Random Forest algorithm yields the best results, with an R2 value of 0.89 and a mean prediction error of about 0.21 m

Coronavirus disease 2019: Facts and controversies

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DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

The repair of DNA double-strand breaks (DSBs) by homologous recombination requires processing of broken ends. For repair to start, the DSB must first be resected to generate a 3′-single-stranded DNA (ssDNA) overhang, which becomes a substrate for the DNA strand exchange protein, Rad51 (ref. 1). Genetic studies have implicated a multitude of proteins in the process, including helicases, nucleases and topoisomerases. Here we biochemically reconstitute elements of the resection process and reveal that it requires the nuclease Dna2, the RecQ-family helicase Sgs1 and the ssDNA-binding protein replication protein-A (RPA). We establish that Dna2, Sgs1 and RPA constitute a minimal protein complex capable of DNA resection in vitro. Sgs1 helicase unwinds the DNA to produce an intermediate that is digested by Dna2, and RPA stimulates DNA unwinding by Sgs1 in a species-specific manner. Interestingly, RPA is also required both to direct Dna2 nucleolytic activity to the 5′-terminated strand of the DNA break and to inhibit 3′ to 5′ degradation by Dna2, actions that generate and protect the 3′-ssDNA overhang, respectively. In addition to this core machinery, we establish that both the topoisomerase 3 (Top3) and Rmi1 complex and the Mre11–Rad50–Xrs2 complex (MRX) have important roles as stimulatory components. Stimulation of end resection by the Top3–Rmi1 heterodimer and the MRX proteins is by complex formation with Sgs1 (refs 5, 6), which unexpectedly stimulates DNA unwinding. We suggest that Top3–Rmi1 and MRX are important for recruitment of the Sgs1–Dna2 complex to DSBs. Our experiments provide a mechanistic framework for understanding the initial steps of recombinational DNA repair in eukaryotes

Temporal Changes of Seismic Velocity Caused by Volcanic Activity at Mt. Etna Revealed by the Autocorrelation of Ambient Seismic Noise

On active volcanoes, ambient noise-based seismic interferometry, able to detect very slight variations in seismic velocity associated with magma transport towards the surface, can be a very useful monitoring tool. In this work, we performed the autocorrelation of ambient seismic noise recorded at Mt. Etna volcano, by three stations located close to the active summit craters, during April 2013 - October 2014. Such an interval was chosen because of the number and variety of eruptions. The method implemented to perform autocorrelation was the phase cross-correlation, which does not require normalization of the signals. The detected seismic velocity variations were very consistent for all three stations throughout the study period, mainly ranging between 0.3 and -0.2%, and were time-related to both sequences of paroxysmal eruptions and more effusive activities. In particular, we observed seismic velocity decreases accompanying paroxysmal eruptions, suggesting an intense pressurization within the plumbing system, which created an area of extensional strain with crack openings. It is worth noting that classical cross-station approach failed to detect seismic velocity changes related to volcano activity. In addition, seismic velocity variations over time were integrated with ground deformation data recorded by GPS stations and volcanic tremor centroid locations. Finally, we showed that, although the investigated frequency band (1-2 Hz) contains most of the volcanic tremor energy, our results did not indicate a particular contamination of seismic velocity variation measurements by variations of tremor sources