11 research outputs found
Development of a cost-effectiveness model for optimisation of the screening interval in diabetic retinopathy screening
Impact of environment on disabled individuals
Meeting: World Commission on Environment and Development, Public Hearing, 26-27 May 1986, Ottawa, ON, CARelated to DAP 87-4249 under which IDRC supported the WCED to acquire and duplicate original papers, submissions, tapes and transcripts, became the depository of all original archival materials and received the right to microfiche the collection for broader disseminatio
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How Virtual Work Environments Convey Perceptual Cues to Foster Shared Intentionality During Covid-19 for Blind and Partially Sighted Employees
The Covid-19 pandemic altered workplaces. For those with ‘office jobs,’ this meant working ‘virtually,’ or remotely, from home. This transition forced organizations and workplaces to exercise flexibility, adapt workflows and rely on Information and Communication Technologies (ICTs) to work remotely. However, Blind and Partially Sighted Individuals (BPSI) face challenges accessing work digitally and remote communications through ICTs. In response, we report on the results of our longitudinal participatory design study investigating the impact of working and training over a distance for BPSI. What emerged is a conceptual model to assist in understanding how ICT interfaces convey spatial-topological cues for the construction of shared intentionality in virtual work environments. The implications of our model could be significant, as it aids understanding of what is lost and gained when transitioning to virtual work environments. This could inform the development of ICTs with cross-sensory interaction and national accessibility policies for the workplace
Low Vision Services in the Asia-Pacific Region: Models of Low Vision Service Delivery and Barriers to Access
Development of a cost-effectiveness model for optimisation of the screening interval in diabetic retinopathy screening
Background: The English NHS Diabetic Eye Screening Programme was established in 2003. Eligible people are invited annually for digital retinal photography screening. Those found to have potentially sight-threatening diabetic retinopathy (STDR) are referred to surveillance clinics or to Hospital Eye Services. Objectives: To determine whether personalised screening intervals are cost-effective. Design: Risk factors were identified in Gloucestershire, UK using survival modelling. A probabilistic decision hidden (unobserved) Markov model with a misgrading matrix was developed. This informed estimation of lifetime costs and quality-adjusted life-years (QALYs) in patients without STDR. Two personalised risk stratification models were employed: two screening episodes (SEs) (low, medium or high risk) or one SE with clinical information (low, medium–low, medium–high or high risk). The risk factor models were validated in other populations. Setting: Gloucestershire, Nottinghamshire, South London and East Anglia (all UK). Participants: People with diabetes in Gloucestershire with risk stratification model validation using data from Nottinghamshire, South London and East Anglia. Main outcome measures: Personalised risk-based algorithm for screening interval; cost-effectiveness of different screening intervals. Results: Data were obtained in Gloucestershire from 12,790 people with diabetes with known risk factors to derive the risk estimation models, from 15,877 people to inform the uptake of screening and from 17,043 people to inform the health-care resource-usage costs. Two stratification models were developed: one using only results from previous screening events and one using previous screening and some commonly available GP data. Both models were capable of differentiating groups at low and high risk of development of STDR. The rate of progression to STDR was 5 per 1000 person-years (PYs) in the lowest decile of risk and 75 per 1000 PYs in the highest decile. In the absence of personalised risk stratification, the most cost-effective screening interval was to screen all patients every 3 years, with a 46% probability of this being cost-effective at a £30,000 per QALY threshold. Using either risk stratification models, screening patients at low risk every 5 years was the most cost-effective option, with a probability of 99-100% at a £30,000 per QALY threshold. For the medium-risk groups screening every 3 years had a probability of 43 –48% while screening high-risk groups every 2 years was cost-effective with a probability of 55–59%. Conclusions: The study found that annual screening of all patients for STDR was not cost-effective. Screening this entire cohort every 3 years was most likely to be cost-effective. When personalised intervals are applied, screening those in our low-risk groups every 5 years was found to be cost-effective. Screening high-risk groups every 2 years further improved the cost-effectiveness of the programme. There was considerable uncertainty in the estimated incremental costs and in the incremental QALYs, particularly with regard to implications of an increasing proportion of maculopathy cases receiving intravitreal injection rather than laser treatment. Future work should focus on improving the understanding of risk, validating in further populations and investigating quality issues in imaging and assessment including the potential for automated image grading. Study registration: Integrated Research Application System project number 118959. Funding details: The National Institute for Health Research Health Technology Assessment programme