11,334 research outputs found
The treatment of mixing in core helium burning models -- III. Suppressing core breathing pulses with a new constraint on overshoot
Theoretical predictions for the core helium burning phase of stellar
evolution are highly sensitive to the uncertain treatment of mixing at
convective boundaries. In the last few years, interest in constraining the
uncertain structure of their deep interiors has been renewed by insights from
asteroseismology. Recently, Spruit (2015) proposed a limit for the rate of
growth of helium-burning convective cores based on the higher buoyancy of
material ingested from outside the convective core. In this paper we test the
implications of such a limit for stellar models with a range of initial mass
and metallicity. We find that the constraint on mixing beyond the Schwarzschild
boundary has a significant effect on the evolution late in core helium burning,
when core breathing pulses occur and the ingestion rate of helium is fastest.
Ordinarily, core breathing pulses prolong the core helium burning lifetime to
such an extent that models are at odds with observations of globular cluster
populations. Across a wide range of initial stellar masses (), applying the Spruit constraint reduces the core
helium burning lifetime because core breathing pulses are either avoided or
their number and severity reduced. The constraint suggested by Spruit therefore
helps to resolve significant discrepancies between observations and theoretical
predictions. Specifically, we find improved agreement for , the observed
ratio of asymptotic giant branch to horizontal branch stars in globular
clusters; the luminosity difference between these two groups; and in
asteroseismology, the mixed-mode period spacing detected in red clump stars in
the \textit{Kepler} field.Comment: Accepted for publication in MNRAS; 11 pages, 6 figure
Time-Domain Measurement of Spontaneous Vibrational Decay of Magnetically Trapped NH
The v = 1 -> 0 radiative lifetime of NH (X triplet-Sigma-, v=1,N=0) is
determined to be tau_rad,exp. = 37.0 +/- 0.5 stat +2.0 / -0.8 sys miliseconds,
corresponding to a transition dipole moment of |mu_10| = 0.0540 + 0.0009 /
-0.0018 Debye. To achieve the long observation times necessary for direct
time-domain measurement, vibrationally excited NH (X triplet-Sigma-, v=1,N=0)
radicals are magnetically trapped using helium buffer-gas loading. Simultaneous
trapping and lifetime measurement of both the NH(v=1, N=0) and NH(v=0,N=0)
populations allows for accurate extraction of tau_rad,exp. Background helium
atoms are present during our measurement of tau_rad,exp., and the rate constant
for helium atom induced collisional quenching of NH(v=1,N=0) was determined to
be k_q < 3.9 * 10^-15 cm^3/s. This bound on k_q yields the quoted systematic
uncertainty on tau_rad,exp. Using an ab initio dipole moment function and an
RKR potential, we also determine a theoretical value of 36.99 ms for this
lifetime, in agreement with our experimental value. Our results provide an
independent determination of tau_rad,10, test molecular theory, and furthermore
demonstrate the efficacy of buffer-gas loading and trapping in determining
metastable radiative and collisional lifetimes.Comment: 10 pages + 3 figures (11 pages total) v2 has minor corrections and
explanations accepted for publication in PR
A qualitative study in rural and urban areas on whether - and how - to consult during routine and out of hours
Peer reviewedPublisher PD
The inquiring mind in a changing world
An address delivered at the nineteenth commencement convocation of the Rice Institute by John Campbell Merriam, President of the Carnegie Institution of Washington
The treatment of mixing in core helium burning models - I. Implications for asteroseismology
The detection of mixed oscillation modes offers a unique insight into the
internal structure of core helium burning (CHeB) stars. The stellar structure
during CHeB is very uncertain because the growth of the convective core, and/or
the development of a semiconvection zone, is critically dependent on the
treatment of convective boundaries. In this study we calculate a suite of
stellar structure models and their non-radial pulsations to investigate why the
predicted asymptotic g-mode period spacing is
systematically lower than is inferred from Kepler field stars. We find that
only models with large convective cores, such as those calculated with our
newly proposed "maximal-overshoot" scheme, can match the average
reported. However, we also find another possible solution that is related to
the method used to determine : mode trapping can raise the
observationally inferred well above its true value. Even after
accounting for these two proposed resolutions to the discrepancy in average
, models still predict more CHeB stars with low ( s) than are observed. We establish two possible remedies for this: i)
there may be a difficulty in determining for early CHeB stars
(when is lowest) because of the effect that the sharp composition
profile at the hydrogen burning shell has on the pulsations, or ii) the mass of
the helium core at the flash is higher than predicted. Our conclusions
highlight the need for the reporting of selection effects in asteroseismic
population studies in order to safely use this information to constrain stellar
evolution theory.Comment: 24 pages. 24 figures. Published in MNRA
Magnetic trapping and Zeeman relaxation of imidogen (NH X-triplet-Sigma)
Imidogen (NH) radicals are magnetically trapped and their Zeeman relaxation
and energy transport collision cross sections with helium are measured.
Continuous buffer-gas loading of the trap is direct from a room-temperature
molecular beam. The Zeeman relaxation (inelastic) cross section of magnetically
trapped electronic, vibrational and rotational ground state imidogen in
collisions with He-3 is measured to be 3.8 +/- 1.1 E-19 cm^2 at 710 mK. The
NH-He energy transport cross section is also measured, indicating a ratio of
diffusive to inelastic cross sections of gamma = 7 E4 in agreement with the
recent theory of Krems et al. (PRA 68 051401(R) (2003))Comment: 12 pages, 3 figure
Association is not causation: treatment effects cannot be estimated from observational data in heart failure
Aims:
Treatment âeffectsâ are often inferred from non-randomized and observational studies. These studies have inherent biases and limitations, which may make therapeutic inferences based on their results unreliable. We compared the conflicting findings of these studies to those of prospective randomized controlled trials (RCTs) in relation to pharmacological treatments for heart failure (HF).
Methods and results:
We searched Medline and Embase to identify studies of the association between non-randomized drug therapy and all-cause mortality in patients with HF until 31 December 2017. The treatments of interest were: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, mineralocorticoid receptor antagonists (MRAs), statins, and digoxin. We compared the findings of these observational studies with those of relevant RCTs. We identified 92 publications, reporting 94 non-randomized studies, describing 158 estimates of the âeffectâ of the six treatments of interest on all-cause mortality, i.e. some studies examined more than one treatment and/or HF phenotype. These six treatments had been tested in 25 RCTs. For example, two pivotal RCTs showed that MRAs reduced mortality in patients with HF with reduced ejection fraction. However, only one of 12 non-randomized studies found that MRAs were of benefit, with 10 finding a neutral effect, and one a harmful effect.
Conclusion:
This comprehensive comparison of studies of non-randomized data with the findings of RCTs in HF shows that it is not possible to make reliable therapeutic inferences from observational associations. While trials undoubtedly leave gaps in evidence and enrol selected participants, they clearly remain the best guide to the treatment of patients
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