Counselors’ Knowledge about HIV Transmission and Prevention

This article presents the results of an online survey study of 80 counselors to explore counselors’ knowledge about Human Immunodeficiency Virus (HIV) transmission, HIV prevention strategies, potentially related factors, and where counselors obtained their knowledge. Results show that approximately 90% of counselors correctly identified knowledge about HIV transmission, 68% correctly identified knowledge about HIV prevention strategies, and 64% reported receiving no education regarding HIV/AIDS in their graduate counseling programs. Implications for counselor training and professional development are discussed

Enabling Space Access to K-12 Through The Virginia Space ThinSat Program

To enhance STEM programs by offering Low Earth Orbit launch opportunity at no expense to participant colleges and universities while simultaneously exposing K-12 institutions to hands on space science and systems engineering

Race-Conscious Affirmative Action: What's Next

An expected national ban on the consideration of race in college admissions will threaten the racial and ethnic diversity of students at selective colleges unless these colleges fundamentally alter their admissions practices. Race-Conscious Affirmative Action: What's Next finds that selective colleges barred from considering race and ethnicity in their admissions decisions may be able to partially claw back some racial/ethnic diversity using class-conscious admissions practices, but they will be extremely unlikely to enroll student bodies that come close to mirroring the demographic diversity of the high school class

Omitted Variable Bias in the Link Between Planning and Performance

This article argues that existing research poorly specifies the link between planning and performance because of omitted variable bias. Researchers agree planning is a critical part of creating any new venture. Many researchers assess planning by whether a small firm has a written business plan. Unfortunately, efforts empirically to validate this relationship have been inconclusive. This article proposes that researchers should assess business plans both on the quality of the plan (and the planning process that produced it), and on the quality of the underlying business opportunity. Failure to account for both aspects of a business plan amounts to omitted variable bias, frustrating attempts to accurately estimate the true relationship

What Works: Ten Education, Training, and Work-Based Pathway Changes That Lead to Good Jobs

All along the journey from youth to young adulthood, there are critical junctures at which a change in pathway can have a tremendous impact on a young person's future. What Works: Ten Education, Training, and Work-Based Pathway Changes That Lead to Good Jobs identifies 10 pathway changes with the greatest potential to improve employment outcomes for young adults. The report uses the Pathways-to-Career policy simulation model, developed by CEW researchers using longitudinal data, to identify promising junctures at which strategic interventions could increase the likelihood of working in a good job

A Comparison of Potential Student Blood Donors to Actual Donors

With a growing need for blood and blood products, managers of blood collection agencies are interested in increasing donation rates. A better understanding of how donors are different from the general public might inform decisions on how to promote to make non-donors more like donors. A sample of 74 student blood donors was surveyed at two university blood donor clinics about their attitudes and beliefs about blood donation. A convenience sample of 134 respondents in a university student population was also surveyed for comparison. The latter was later split by level of commitment to blood donation. Differences among these three groups were tested. Applications of these finding are suggested

Relationships Between Indices of Macrovascular and Microvascular Function in Young, Black Women

Blacks (BL) exhibit an exaggerated prevalence of and mortality from cardiovascular disease (CVD) relative to other populations. Macro- and microvascular dysfunction is often a hallmark of heightened CVD risk, with both demonstrated in BL. However, data regarding this dysfunction remains sparse, particularly in BL women. Common indices of vascular function include flow-mediated dilation (FMD) and reactive hyperemia (RH) following a brief period of suprasystolic cuff occlusion and cutaneous thermal reactivity to local heating (LH). However, the relationship between these indices has not been established in BL women. PURPOSE: The present study aimed to test the relationship between indices of vascular function in BL women as assessed by FMD, RH, and LH. METHODS: To test this hypothesis, 6 white women (WW) and 6 BW (age: 22±2 vs. 21±3, respectively) were studied. FMD and RH were assessed following a period of suprasystolic cuff occlusion. Briefly, a rapid inflation cuff was secured just distal to the antecubital fossa for arterial occlusion. Blood velocity (Vmean; cm ∙ s-1) and vessel diameter (d; mm) were measured continuously via high-resolution, duplex Doppler ultrasound during a 2-min baseline, 5-min of cuff occlusion, and 3-min of recovery. FMD was determined as the percent dilation from baseline (%FMD) while RH was determined as the peak and area under the curve (AUC) responses for shear rate (8 ∙ Vmean ∙ d-1) and blood flow (Vmean ∙ π ∙ (d ∙ 20-1)2 ∙ 60). Cutaneous thermal reactivity was assessed using laser-Doppler flowmetry during a standard LH protocol and reported as cutaneous vascular conductance (CVC; red blood cell flux/mean arterial pressure). Following a baseline with local skin temperature clamped at 33°C, a 39°C heat stimulus was applied to induce cutaneous vasodilation for ~30-min. The sustained vasodilation at the end of heating is predominantly nitric oxide mediated and provides an index of microvascular function. As the LH component served as part of a larger intradermal microdialysis protocol, maximal blood flow responses were elicited via combined intradermal sodium nitroprusside (28mM) infusion and 43°C heating. CVC during the 39°C plateau was normalized to maximal CVC (%CVCmax) to account for intersite variability. Pearson correlations were then performed between the FMD, RH, and LH responses. RESULTS: Significant relationships were observed between %FMD and shear AUC (r = 0.89; P = 0.02), and blood flow AUC (r = 0.92; P = 0.01) in WW, but not in BW (r = 0.63; P = 0.18 and r = -0.24; P = 0.65, respectively). However, neither FMD nor RH correlated with the cutaneous blood flow responses to LH (P \u3e 0.05) in either WW or BW. CONCLUSION: These preliminary data suggest that FMD is highly correlated to some indices of RH in WW, but that this relationship does not hold in BW. Further, there appears to be no relationship between microvascular function as assessed by RH and LH in either population

Bloom syndrome: research and data priorities for the development of precision medicine as identified by some affected families

Bloom syndrome (BS) is a rare, autosomal recessive genetic disorder characterized by short stature, a skin rash associated with sun exposure, and an elevated likelihood of developing cancers of essentially all types, beginning at an early age. Cancer is the leading cause of death for persons with BS, and its early onset results in a reported median lifespan of <30 years. With fewer than 300 documented cases since BS was first described in 1954, its rarity has challenged progress in advancing both the care of and the cure for persons with BS. Presently, there are no known clinically actionable targets specific to persons with this cancer predisposition syndrome, despite the fact that standard cancer treatments are often contraindicated or must be substantially modified for persons with BS. Herein, Zachary Rogers recounts his experience as a cancer patient with BS contemplating a substantially customized chemotherapy regimen that highlights the need for development of individualized treatments in the BS community. We also outline a patient-centered research and community action road map with the goal of improving and prolonging the lives of persons with Bloom syndrome, including the facilitation of precision medicine development specific to this condition