Tagging ATG5 with an epitope tag to measure the amount of ATG12-5 conjugation in atg10 mutants

Autophagy is a necessary recycling process that occurs in cells, but the functions of the proteins that carry this out are not completely understood. The protein ATG10 has a distinct role in forming autophagosomes, large double membrane vesicles necessary for this process. ATG10 forms a covalent bond between the proteins ATG12 and ATG5 but its final effect on autophagosome formation is still unclear. We are using DNA manipulation techniques to add a myc epitope tag to yeast ATG5 which will allow us to measure the effect of atg10 mutants on ATG12-5 conjugation via Western Blot. These results will help us correlate ATG10 activity to autophagosome size and number

Examining interwoven narratives: multidirectional memory between enslaved labourers and mill workers in Northern England heritage sites

This article examines two heritage site case studies that juxtapose historical British mill workers with enslaved labourers working on cotton plantations in the Americas, thus creating what Michael Rothberg has termed ‘multidirectional memory’. Through close analysis of the People’s History Museum in Manchester and Cromford Mills in Derbyshire, the article engages with the difficult issue of guilt, the role of community co-production and the potential power of such displays to disrupt division and promote solidarity, while acknowledging challenges involved

An appeal to supersede the slave trade triangle in English museums

In 2007 several permanent museum galleries were created in England that discuss the subject of the transatlantic slave trade and slavery. This article critiques one recurring image within many of these sites: the diagrams of the slave trade triangle. Drawing on analyses of the slave trade by historians, from Eric Williams to recent contributions, as well as understanding of the behaviour of museum visitors, it appeals to museums for more complex diagrams to be included in future installations at public history sites. Methodologically, close analysis of current museum installations frames exploration of the historical complexities and geographic expanse of enslavement-associated commerce, a term coined within the article. Future diagrams reflecting these complications will more accurately represent historical scholarship and the importance of enslaved labour to global commerce, rather than understating this by focusing solely on the slave trade triangle

Chemiresistive Sensor Arrays from Conductive 2D Metal–Organic Frameworks

Applications of porous metal–organic frameworks (MOFs) in electronic devices are rare, owing in large part to a lack of MOFs that display electrical conductivity. Here, we describe the use of conductive two-dimensional (2D) MOFs as a new class of materials for chemiresistive sensing of volatile organic compounds (VOCs). We demonstrate that a family of structurally analogous 2D MOFs can be used to construct a cross-reactive sensor array that allows for clear discrimination between different categories of VOCs. Experimental data show that multiple sensing mechanisms are operative with high degrees of orthogonality, establishing that the 2D MOFs used here are mechanistically unique and offer advantages relative to other known chemiresistor materials.Camille & Henry Dreyfus Foundation. Postdoctoral Program in Environmental ChemistrAlfred P. Sloan FoundationResearch Corporation for Science Advancement3M CompanyNational Science Foundation (U.S.). Graduate Research Fellowship Program (Grant 1122374)Massachusetts Institute of Technology. Institute for Soldier Nanotechnologie

Beyond Abolition: Challenging the “un-visibility” of enslavement-associated commerce in England and New England

This research analyses 48 heritage sites in England and New England, which offered narratives of transatlantic slavery in 2018–2019. Building on previous critiques of public memory of slavery, I focus on highlighting the economic connections of what I term enslavement-associated commerce (EAC). Researching sites in England and New England enabled a transnational comparison between two regions that both profited from enslavement, but largely at a geographic distance. I argue that changing our focus of vision from sites of enslavement to sites of EAC reveals the widespread spectral traces, impact, and importance of slavery to both England and New England. In both regions the analysed sites of intervention participate in the act of challenging the “un-visibility” of EAC, which was buried beneath abolition, as part of what I call the defenders of liberty heritage narrative (DOLHN). Conscious of this context, this thesis draws on decades of historical literature to undertake in-depth analysis of the scope of narratives offered, across the 48 case studies. These include museums, memorials, historic houses and cotton mills. I investigate whether the interventions within these sites effectively acknowledge the impact of EAC, and consequently its relevance to the heritage narratives of England and New England. While collectively they do reveal the importance of EAC, there are recurring limitations in the narratives, including a predominant focus on individual wealthy enslavers and ports. Moving forward, I encourage the development of more complex narratives of EAC, which better recognise the contribution of enslaved labourers to modern capitalism

Transition to PCR diagnosis of cryptosporidiosis and giardiasis in the Norwegian healthcare system: could the increase in reported cases be due to higher sensitivity or a change in the testing algorithm?

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Exhibition Review: Disobedient Objects, Victoria and Albert Museum, London, 26 July 2014 – 1 February 2015

- ELECTRONIC SUPERHIGHWAY 2016–1966, THE WHITECHAPEL GALLERY, LONDON, 29 JANUARY–15 MAY 2016 - KERRY GUINAN, LIBERATE ART POLITICAL PROGRAMME AND PRESS RELEASE EVENT, TEMPLE BAR GALLERY AND STUDIOS, DUBLIN, 15 FEBRUARY 2016 - TOMORROW WAS A MONTAGE, COOPER GALLERY, DUNCAN OF JORDANSTONE COLLEGE OF ART AND DESIGN, 30 OCTOBER– 18 DECEMBER 2015 - DISOBEDIENT OBJECTS, VICTORIA AND ALBERT MUSEUM, LONDON, 26 JULY 2014–1 FEBRUARY 201

Borders and Catastrophe: lessons from COVID-19 for the European Green Deal

This article considers how the European Union and Member States’ responses to the COVID-19 crisis in the first half of 2020 could inform climate action in Europe, and particularly the resumption of actions on the EGD. It first outlines the EU’s public health and economic responses to COVID-19 and Europe’s role in the global response to the pandemic. We find that, based on the challenges and successes of all these responses, a strong argument can be made for ‘more Europe’ – greater integration, and stronger EU-level institutions – to lead and govern the COVID-19 response. This has direct lessons for the governance and scope of future climate action