3,723 research outputs found
Mostly Minnesota Art Song: Songs by Barber, Campbell, Erickson, Larsen, Maurer, Phipps-Kettlewell, Rossi, and Thomas
Tracks 1-6 are from David Evan Thomas\u27 Divine Images collection, based on the poetry of William Blake. Tracks 16-20 are from Brian G. Campbell\u27s collection This is My Letter to the World: Five Emily Dickinson Songs.https://digitalcommons.csbsju.edu/music_recordings/1014/thumbnail.jp
Rotorcraft Transmission Noise Path Model, Including Distributed Fluid Film Bearing Impedance Modeling
A computational approach for simulating the effects of rolling element and journal bearings on the vibration and sound transmission through gearboxes has been demonstrated. The approach, using ARL/Penn State s CHAMP methodology, uses Component Mode Synthesis of housing and shafting modes computed using Finite Element (FE) models to allow for rapid adjustment of bearing impedances in gearbox models. The approach has been demonstrated on NASA GRC s test gearbox with three different bearing configurations: in the first condition, traditional rolling element (ball and roller) bearings were installed, and in the second and third conditions, the traditional bearings were replaced with journal and wave bearings (wave bearings are journal bearings with a multi-lobed wave pattern on the bearing surface). A methodology for computing the stiffnesses and damping in journal and wave bearings has been presented, and demonstrated for the journal and wave bearings used in the NASA GRC test gearbox. The FE model of the gearbox, along with the rolling element bearing coupling impedances, was analyzed to compute dynamic transfer functions between forces applied to the meshing gears and accelerations on the gearbox housing, including several locations near the bearings. A Boundary Element (BE) acoustic model was used to compute the sound radiated by the gearbox. Measurements of the Gear Mesh Frequency (GMF) tones were made by NASA GRC at several operational speeds for the rolling element and journal bearing gearbox configurations. Both the measurements and the CHAMP numerical model indicate that the journal bearings reduce vibration and noise for the second harmonic of the gear meshing tones, but show no clear benefit to using journal bearings to reduce the amplitudes of the fundamental gear meshing tones. Also, the numerical model shows that the gearbox vibrations and radiated sound are similar for journal and wave bearing configurations
TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions
<p>Abstract</p> <p>Background</p> <p>The TRIM5 proteins are cellular restriction factors that prevent retroviral infection in a species-specific manner. Multiple experiments indicate that restriction activity requires accessory host factors, including E2-enzymes. To better understand the mechanism of restriction, we conducted yeast-two hybrid screens to identify proteins that bind to two TRIM5 orthologues.</p> <p>Results</p> <p>The only cDNAs that scored on repeat testing with both TRIM5 orthologues were the proteasome subunit PSMC2 and ubiquitin. Using co-immunoprecipitation assays, we demonstrated an interaction between TRIM5α and PSMC2, as well as numerous other proteasome subunits. Fluorescence microscopy revealed co-localization of proteasomes and TRIM5α cytoplasmic bodies. Forster resonance energy transfer (FRET) analysis indicated that the interaction between TRIM5 and PSMC2 was direct. Previous imaging experiments demonstrated that, when cells are challenged with fluorescently-labeled HIV-1 virions, restrictive TRIM5α orthologues assemble cytoplasmic bodies around incoming virion particles. Following virus challenge, we observed localization of proteasome subunits to rhTRIM5α cytoplasmic bodies that contained fluorescently labeled HIV-1 virions.</p> <p>Conclusions</p> <p>Taken together, the results presented here suggest that localization of the proteasome to TRIM5α cytoplasmic bodies makes an important contribution to TRIM5α-mediated restriction.</p
Mental Health Professionalsâ Attitudes toward Clients with Antisocial Personality Disorder: An Exploratory Study
This exploratory study examined mental health professionalsâ attitudes toward clients with antisocial personality disorder. Specifically, are mental health professionalsâ attitudes influenced by (a) personal experiences with criminal victimization, or (b) contact with clients with antisocial personality disorder. A factorial MANOVA and follow-up univariate ANOVAs revealed a statistically significant main effect in relation to participantsâ level of clinical contact with clients having antisocial personality disorder. Participants with higher levels of clinical contact were associated with more positive attitudes towards clients. Implications for mental health professionals, supervisors, and counselor educators are discussed, and suggestions for future research are provided
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Effects of melting conditions on platinum-inclusion content in phosphate laser glasses
Results from small-scale glass melting experiments aimed at reducing the density of platinum particles in phosphate laser glasses are discussed. The platinum particles originate from the crucibles used to melt the laser glass and can cause optical damage in glasses used in high-peak-power lasers. The melting experiments examine the effects of a) temperature and temperature gradients; b) processing time; and c) Oâ atmosphere on the formation and dissolution of platinum inclusions in LG-750 phosphate laser glass. Results show that most platinum inclusions originate early in the melt cycle, with thermal gradients within the melter being one of the major causes. By using oxidizing conditions (Oâ), the platinum inclusions can be dissolved into the glass during the course of the melt cycle. Results from the laboratory-scale melting experiments have been incorporated into a proprietary laser-glass melting process. The laser glass prepared under these conditions has an average of less than 0.1 platinum inclusions/1, which represents a 1000-fold reduction over the previously available phosphate laser glasses
Intraoperative Mapping and Radiofrequency Ablation of the His Bundle in a Patient with Complex Congenital Heart Disease and Intractable Atrial Arrhythmias Following the Fontan Operation
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75047/1/j.1540-8159.1993.tb01741.x.pd
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