Electron Self-Trapping in Ge\u3csub\u3e2\u3c/sub\u3e Se\u3csub\u3e3\u3c/sub\u3e and Its Role in Ag and Sn Incorporation

We present a set of density functional theory (DFT) calculations on the electronic structure of Ag and Sn in Ge2 Se3 in a periodic model. We show that electron self-trapping is a persistent feature in the presence of many defects. Ag and Sn autoionize upon entering Ge2 Se3 becoming Ag+ and Sn2+ , respectively, and the freed electrons self trap at the lowest energy site. Both Ag and Sn can substitute for Ge, and we present formation energies as a function of Fermi level that show that Sn can substantially alter the incorporation of Ag into the Ge2Se3 network

Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-X(L)

BACKGROUND: Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases. Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim expression has been observed in several human cancers. RESULTS: Here we show that the pim kinases are constitutively active when expressed in HEK-293 cells and are able to phosphorylate the Bcl-2 family member Bad on three residues, Ser112, Ser136 and Ser155 in vitro and in cells. In vitro mapping showed that Pim-2 predominantly phosphorylated Ser112, while Pim-1 phosphorylated Ser112, but also Ser136 and Ser155 at a reduced rate compared to Ser112. Pim-3 was found to be the least specific for Ser112, and the most effective at phosphorylating Ser136 and Ser155. Pim-3 was also able to phosphorylate other sites in Bad in vitro, including Ser170, another potential in vivo site. Mutation of Ser136 to alanine prevented the phosphorylation of Ser112 and Ser155 by Pim kinases in HEK-293 cells, suggesting that this site must be phosphorylated first in order to make the other sites accessible. Pim phosphorylation of Bad was also found to promote the 14-3-3 binding of Bad and block its association with Bcl-X(L). CONCLUSION: All three Pim kinase family members predominantly phosphorylate Bad on Ser112 and in addition are capable of phosphorylating Bad on multiple sites associated with the inhibition of the pro-apoptotic function of Bad in HEK-293 cells. This would be consistent with the proposed function of Pim kinases in promoting cell proliferation and preventing cell death

Physiology

Contains reports on three research projects

Physiology

Contains reports on four research projects

Physiology

Contains reports on four research projects.Bell Laboratories, Inc.Ortho InstrumentsThe Rowland Foundation, Inc

Acute lethal and behavioral sublethal responses of two stored-product psocids to surface insecticides

BACKGROUND: The psocids Liposcelis bostrychophila Badonnel and L. entomophila (Enderlein) (Liposcelididae) are emerging pests of stored products. Although their behavior, particularly their high mobility, may contribute to the reported relatively low efficacy of insecticides against them, studies to investigate this have not been conducted. The present study aimed to assess the label rate efficacy of three commercial insecticides (β-cyfluthrin, chlorfenapyr and pyrethrins) applied on concrete surfaces against L. bostrychophila and L. entomophila, and also their sublethal effect on the mobility of these species. RESULTS: The synthetic insecticides β-cyfluthrin and chlorfenapyr showed high short-term efficacy (LT95 ≤ 15 h) against both psocid species, unlike the natural pyrethrins (LT95 ≥ 4 days). Liposcelis bostrychophila was slightly more tolerant (≥1.2×) than L. entomophila to all three insecticides. Behavioral assays with fully sprayed and half-sprayed concrete arenas indicated that the insecticides reduced the mobility of both species. Pyrethrins seem to elicit weak repellence in L. bostrychophila. CONCLUSION: β-Cyfluthrin and chlorfenapyr were effective against both psocid species, but not pyrethrins. The mobility of both species does not seem to play a major role in the differential selectivity observed, but the lower mobility of L. bostrychophila may be a contributing factor to its higher insecticide tolerance

Report of the Advisory Committee in Seismology

The Advisory Committee in Seismology has pleasure in reporting the continued progress of its study of California earth movements during the year 1924-1925 without essential change of plan. A considerable amount of geologic work in the study of fault zones has been done during the year in the Mojave Desert and in Death Valley, the system of primary triangulation for the detection and measurement of horizontal displacements has progressed rapidly and effectively, and the development of suitable instruments for determining the two horizontal components of local earth movements has progressed to completion. Ground for a new laboratory has been purchased by the California Institute of Technology and the construction of the central station laboratory building upon it has been begun. The laboratory is expected to be occupied by Mr. H. O. Wood, Research Associate in Seismology, and his associates, about January 1, 1926. It is hoped that additional stations will also be occupied before the close of the present calendar year (1925), and that actual work in what has been happily termed the seismologic triangulation of California will be successfully inaugurated

The RMS Survey: Mid-Infrared Observations of Candidate Massive YSOs in the Southern Hemisphere

Abridged abstract: The Red MSX Source (RMS) survey is an ongoing effort to return a large, well-selected sample of massive young stellar objects (MYSOs) within our Galaxy. A series of ground-based follow-up observations are being undertaken in order to remove contaminant objects from our list of 2000 candidates, and to begin characterising these MYSOs. As a part of these follow-up observations, high resolution (~1") mid-IR imaging aids the identification of contaminant objects which are resolved (UCHII regions, PN) as opposed to those which are unresolved (YSOs, evolved stars) as well as identifying YSOs near UCHII regions and other multiple sources. We present 10.4 micron imaging observations for 346 candidate MYSOs in the RMS survey in the Southern Hemisphere, primarily outside the region covered by the GLIMPSE Spitzer Legacy Survey. These were obtained using TIMMI2 on the ESO 3.6m telescope in La Silla, Chile. Our photometric accuracy is of order 0.05Jy, and our astrometric accuracy is 0.8", which is an improvement over the nominal 2" accuracy of the MSX PSC.Comment: 9 page paper accepted to A&A. Online data for table 2 and figure 1 will be available in the published online version of this paper via A&A. The paper contains 7 figures and 3 table