1,028 research outputs found

    On mapping functions for torsional analysis of splined shafts

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    Mapping functions for torsional analysis of splined shaft

    SBV regularity for Hamilton-Jacobi equations in Rn\mathbb R^n

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    In this paper we study the regularity of viscosity solutions to the following Hamilton-Jacobi equations tu+H(Dxu)=0inΩR×Rn. \partial_t u + H(D_{x} u)=0 \qquad \textrm{in} \Omega\subset \mathbb R\times \mathbb R^{n} . In particular, under the assumption that the Hamiltonian HC2(Rn)H\in C^2(\mathbb R^n) is uniformly convex, we prove that DxuD_{x}u and tu\partial_t u belong to the class SBVloc(Ω)SBV_{loc}(\Omega).Comment: 15 page

    Nicotinamide and calcipotriol counteract UVB-induced photoaging on primary human dermal fibroblasts

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    Background: Photoaging is mainly caused by ultraviolet radiations inasmuch they can damage the DNA, trigger ROS production, and activate p53/p21 pathway, which cause cell cycle arrest and senescence. The accumulationof senescent cells within the dermis contributes to tissue deregulation and skin carcinogenesis. However, the use of photoprotector molecules could reduce UV-induced damages and prevent photoaging. Therefore, the aim of this study is to evaluate whether the active forms of vitamin B3 (nicotinamide) and the analog of vitamin D3 (calcipotriol) might protect primary human dermal fibroblasts (HDFs) from UVB-induced photoaging. Methods: HDFs were isolated from a healthy adult donor and stimulated with nicotinamide (25 μM) and calcipotriol (100 nM) for 24h before UVB exposure, and then, cultured for further 24h on vitamin-supplemented media. Then, cell viability, ROS production, DNA damages, senescence markers, protein and gene expression were evaluated. Results: HDFs treated with nicotinamide and calcipotriol showed better proliferation properties and lower DNA damages due to a reduced UVB-induced ROS production. Consequently, p53/p21 pathway was less active which enhanced cell cycle progression and reduced senescence and cell death. Conclusions: Overall, our results suggest that nicotinamide and calcipotriol can counteract UVB-induced effects responsible for the onset of skin photoaging

    Familial idiopathic dilated cardiomyopahty

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    SAGUNTO (Valencia). Batallas. 1823 (1811). 1:50.000

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    Precede al tit.: Le Sezioni di Livello s'intendono di 4 Metri equidistanti. Tav. VGrabado firmado al verso por el autorOrientado con flecha y rosa de 8 vientosRelieve representado por curvas de nivel, normales y sombreadoTabla de signos convencionales para indicar la situación de las tropasLeyenda explicativa sobre el asedioTexto en la parte inferior: Il Rapporto fra la scalla e il vero é di 1 a 4000
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