On mapping functions for torsional analysis of splined shafts

Mapping functions for torsional analysis of splined shaft

Are Green Roofs an Answer to New York City's Combined Sewer Overflow Problem?: Using Stormwater Utility Fees to Incentivize Green Roofs

Impervious surfaces comprise nearly 70% of New York City’s land mass and contribute to runoff, ultimately becoming Combined Sewer Overflow (CSO) that is discharged through hundreds of outfalls to local waterways. This thesis has explored the viability of green infrastructure to manage stormwater runoff in New York City by using stormwater utility fees to incentivize green roofs. This research posits that implementing stormwater utility fees that are based on percentage of impervious cover on a parcel could incentivize the presence of green infrastructure, and specifically green roofs. This study aggregated and expanded upon a report done by The Urban Design Lab in 2012, which provided a baseline for creating a methodology to generate a series of query expressions within available PLUTO data. This formed a foundation on which a matrix was created to determine what this research calls “structurality” of buildings, through conducting a series of calculations to determine which borough(s) had buildings that were most amenable to accommodating green roofs. Using that data as a launching point, research conducted by teams led by Dr. Gaffin and Dr. Rosenzweig at the Earth Institute provided a foundation for exploring the possible rates of retention for green roofs in New York City. Publicly available city and state initiatives, as well as scholarly research and scientific reports were also consulted for this research. Lastly, this thesis was guided by literature published by the U.S. Environmental Protection Agency that focused on different methodologies for implementing stormwater utility fees, and looked at 23 municipalities with such fees. Focusing on Seattle as an example, this study presented two possible recommendations for developing a stormwater utility fee appropriate for New York City

Pancreatic islet transplantation: an update.

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SBV regularity for Hamilton-Jacobi equations in Rn\mathbb R^n

In this paper we study the regularity of viscosity solutions to the following Hamilton-Jacobi equations $$\partial_t u + H(D_{x} u)=0 \qquad \textrm{in} \Omega\subset \mathbb R\times \mathbb R^{n} .$$ In particular, under the assumption that the Hamiltonian $H\in C^2(\mathbb R^n)$ is uniformly convex, we prove that $D_{x}u$ and $\partial_t u$ belong to the class $SBV_{loc}(\Omega)$.Comment: 15 page

Nicotinamide and calcipotriol counteract UVB-induced photoaging on primary human dermal fibroblasts

Background: Photoaging is mainly caused by ultraviolet radiations inasmuch they can damage the DNA, trigger ROS production, and activate p53/p21 pathway, which cause cell cycle arrest and senescence. The accumulationof senescent cells within the dermis contributes to tissue deregulation and skin carcinogenesis. However, the use of photoprotector molecules could reduce UV-induced damages and prevent photoaging. Therefore, the aim of this study is to evaluate whether the active forms of vitamin B3 (nicotinamide) and the analog of vitamin D3 (calcipotriol) might protect primary human dermal fibroblasts (HDFs) from UVB-induced photoaging. Methods: HDFs were isolated from a healthy adult donor and stimulated with nicotinamide (25 μM) and calcipotriol (100 nM) for 24h before UVB exposure, and then, cultured for further 24h on vitamin-supplemented media. Then, cell viability, ROS production, DNA damages, senescence markers, protein and gene expression were evaluated. Results: HDFs treated with nicotinamide and calcipotriol showed better proliferation properties and lower DNA damages due to a reduced UVB-induced ROS production. Consequently, p53/p21 pathway was less active which enhanced cell cycle progression and reduced senescence and cell death. Conclusions: Overall, our results suggest that nicotinamide and calcipotriol can counteract UVB-induced effects responsible for the onset of skin photoaging

Correction to: Vitamin K effects in human health: new insights beyond bone and cardiovascular health

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Pertussis in early life: underdiagnosed, severe, and risky disease. A seven-year experience in a pediatric tertiary-care hospital

Aim Pertussis continues to be a common worldwide infection in pediatric and adult populations. We aimed to study epidemiological and clinical characteristics of infants and children admitted for pertussis to a tertiary-care hospital and to investigate the risk factors for pediatric intensive care unit (PICU) admission. Materials and Methods With a retrospective study, we analyzed all medical reports of patients admitted to Bambino Gesu Children's Hospital in Rome from January 2011 to December 2018 with a diagnosis of pertussis. Results We examined 195 patients. The majority of hospitalized children (66.15%) were <3 months of age. No mother had received pertussis containing vaccine during pregnancy. Ten cases required admission in PICU. The age at admission was lower in PICU patients with respect to ward patients (42.8 vs 240 days;p< .0007), length of hospital stay was longer in PICU group (24.7 vs 7.52 days;p< .003). Patients who needed PICU admission had greater white blood cell count at hospital admission compared with those hospitalized in the pediatric ward. One infant died and one had encephalitis. Conclusions Pertussis is a remerging disease. In infants, it is associated with significant morbidity and mortality. In recent years, many countries have implemented different vaccination strategies and public health measures to prevent the increase in pertussis cases. Maternal vaccination has been shown to be highly protective for infants <3 months of age before they can develop their own immunity via vaccination